Nlk (nemo like kinase) - Rat Genome Database

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Gene: Nlk (nemo like kinase) Rattus norvegicus
Analyze
Symbol: Nlk (Ensembl: Tmem97)
Name: nemo like kinase (Ensembl:transmembrane protein 97)
RGD ID: 1561602
Description: Predicted to enable several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including negative regulation of signal transduction; protein phosphorylation; and protein stabilization. Predicted to act upstream of or within protein autophosphorylation. Predicted to be active in cytoplasm and nucleus. Biomarker of myocardial infarction. Orthologous to human NLK (nemo like kinase); PARTICIPATES IN Wnt signaling, non-canonical pathway; mitogen activated protein kinase signaling pathway; Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC497961; nemo-like kinase; RGD1561602; serine/threonine-protein kinase NLK; similar to nemo like kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Nlk-ps1   Nlkl1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,965,432 - 64,089,006 (-)NCBIGRCr8
mRatBN7.21063,467,388 - 63,590,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,438,222 - 63,589,730 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,100,088 - 68,223,771 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,605,424 - 67,729,112 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,075,035 - 63,198,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,840,052 - 65,963,932 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,840,052 - 65,963,932 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,679,688 - 65,803,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,681,240 - 64,804,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1062,443,192 - 62,566,809 (-)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of Nemo-like kinase (NLK) in the brain in a rat experimental subarachnoid hemorrhage model. Chen G, etal., Cell Biochem Biophys. 2013 Jul;66(3):671-80. doi: 10.1007/s12013-012-9511-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK). Huang Y, etal., Curr Pharm Des. 2016;22(31):4868-4875. doi: 10.2174/1381612822666160210143047.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Expression of Nemo-like kinase after spinal cord injury in rats. Xu D, etal., J Mol Neurosci. 2014 Mar;52(3):410-8. doi: 10.1007/s12031-013-0191-5. Epub 2014 Jan 7.
Additional References at PubMed
PMID:9448268   PMID:14720327   PMID:15004007   PMID:15082531   PMID:15870890   PMID:16714285   PMID:17785444   PMID:22127415   PMID:25512613   PMID:27577116  


Genomics

Comparative Map Data
Nlk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,965,432 - 64,089,006 (-)NCBIGRCr8
mRatBN7.21063,467,388 - 63,590,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,438,222 - 63,589,730 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,100,088 - 68,223,771 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,605,424 - 67,729,112 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,075,035 - 63,198,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,840,052 - 65,963,932 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,840,052 - 65,963,932 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,679,688 - 65,803,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,681,240 - 64,804,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1062,443,192 - 62,566,809 (-)NCBICelera
Cytogenetic Map10q25NCBI
NLK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,042,677 - 28,206,074 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,041,737 - 28,196,381 (+)EnsemblGRCh38hg38GRCh38
GRCh371726,369,703 - 26,523,407 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,393,815 - 23,547,534 (+)NCBINCBI36Build 36hg18NCBI36
Build 341723,393,311 - 23,547,529NCBI
Celera1723,231,487 - 23,385,144 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,577,205 - 22,730,952 (+)NCBIHuRef
CHM1_11726,432,421 - 26,586,156 (+)NCBICHM1_1
T2T-CHM13v2.01728,984,080 - 29,146,552 (+)NCBIT2T-CHM13v2.0
Nlk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,457,994 - 78,588,848 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,457,994 - 78,588,199 (-)EnsemblGRCm39 Ensembl
GRCm381178,567,168 - 78,697,595 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,567,168 - 78,697,373 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,380,670 - 78,510,927 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,383,363 - 78,513,568 (-)NCBIMGSCv36mm8
Celera1188,199,239 - 88,330,046 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Nlk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,828,448 - 4,973,734 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,828,441 - 4,973,734 (-)NCBIChiLan1.0ChiLan1.0
NLK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,261,930 - 36,421,377 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11738,142,874 - 38,304,762 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,586,894 - 28,740,252 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11729,088,423 - 29,238,427 (-)NCBIpanpan1.1PanPan1.1panPan2
NLK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,399,930 - 42,557,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,400,219 - 42,556,904 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,556,057 - 41,714,082 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,217,710 - 43,376,100 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,217,727 - 43,376,098 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,002,185 - 42,160,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,292,841 - 42,451,988 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,370,442 - 42,528,824 (+)NCBIUU_Cfam_GSD_1.0
Nlk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,443,049 - 41,588,230 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,320,907 - 4,466,168 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,321,018 - 4,466,175 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,403,021 - 44,553,518 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,402,990 - 44,553,527 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,249,416 - 46,458,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NLK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11621,806,642 - 21,959,483 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660758,172,653 - 8,332,957 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624786763,819 - 904,188 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624786763,857 - 910,077 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nlk
427 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:563
Count of miRNA genes:271
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000011726
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106134541366743655Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D11Bhm63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,501,155 - 63,501,240 (+)MAPPERmRatBN7.2
Rnor_6.01065,874,045 - 65,874,129NCBIRnor6.0
Rnor_5.01065,769,491 - 65,769,575UniSTSRnor5.0
RGSC_v3.41064,715,233 - 64,715,317UniSTSRGSC3.4
Celera1062,477,185 - 62,477,269UniSTS
Cytogenetic Map10q25UniSTS
BF386532  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,543,505 - 63,543,667 (+)MAPPERmRatBN7.2
Rnor_6.01065,916,387 - 65,916,548NCBIRnor6.0
Rnor_5.01065,727,072 - 65,727,233UniSTSRnor5.0
RGSC_v3.41064,757,575 - 64,757,736UniSTSRGSC3.4
Celera1062,519,528 - 62,519,689UniSTS
Cytogenetic Map10q25UniSTS
RH139330  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01065,687,902 - 65,688,139NCBIRnor5.0
RGSC_v3.41064,796,490 - 64,796,726UniSTSRGSC3.4
Celera1062,558,400 - 62,558,636UniSTS
RH 3.4 Map8407.3UniSTS
Cytogenetic Map10q25UniSTS
Nlk-ps1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21315,936,679 - 15,937,327 (+)MAPPERmRatBN7.2
Rnor_6.01319,213,740 - 19,214,387NCBIRnor6.0
Rnor_5.01324,416,981 - 24,417,628UniSTSRnor5.0
RGSC_v3.4135,491,101 - 5,491,748UniSTSRGSC3.4
Celera1315,966,288 - 15,966,935UniSTS
Cytogenetic Map10q25UniSTS
Cytogenetic Map13p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011726   ⟹   ENSRNOP00000011726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,467,163 - 63,589,730 (-)Ensembl
Rnor_6.0 Ensembl1065,840,052 - 65,963,932 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000011808   ⟹   ENSRNOP00000011834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,438,228 - 63,447,380 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112106   ⟹   ENSRNOP00000094907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,438,222 - 63,589,730 (-)Ensembl
RefSeq Acc Id: NM_001191924   ⟹   NP_001178853
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,088,888 (-)NCBI
mRatBN7.21063,467,388 - 63,590,850 (-)NCBI
Rnor_6.01065,840,052 - 65,963,932 (-)NCBI
Rnor_5.01065,679,688 - 65,803,568 (+)NCBI
Celera1062,443,192 - 62,566,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086614   ⟹   XP_038942542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,089,006 (-)NCBI
mRatBN7.21063,467,388 - 63,590,928 (-)NCBI
RefSeq Acc Id: XM_063269639   ⟹   XP_063125709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,970,478 - 64,088,995 (-)NCBI
RefSeq Acc Id: XM_063269640   ⟹   XP_063125710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,009,549 (-)NCBI
RefSeq Acc Id: XM_063269641   ⟹   XP_063125711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,009,549 (-)NCBI
RefSeq Acc Id: XM_063269642   ⟹   XP_063125712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,009,549 (-)NCBI
RefSeq Acc Id: XM_063269643   ⟹   XP_063125713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,009,549 (-)NCBI
RefSeq Acc Id: XM_063269644   ⟹   XP_063125714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,087,282 (-)NCBI
RefSeq Acc Id: XM_063269645   ⟹   XP_063125715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,087,340 (-)NCBI
RefSeq Acc Id: XM_063269646   ⟹   XP_063125716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,965,432 - 64,009,549 (-)NCBI
RefSeq Acc Id: XM_063269648   ⟹   XP_063125718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,986,452 - 64,088,992 (-)NCBI
RefSeq Acc Id: NP_001178853   ⟸   NM_001191924
- UniProtKB: D3ZSZ3 (UniProtKB/Swiss-Prot),   A0A8I6AN12 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011726   ⟸   ENSRNOT00000011726
RefSeq Acc Id: XP_038942542   ⟸   XM_039086614
- Peptide Label: isoform X1
- UniProtKB: D3ZSZ3 (UniProtKB/Swiss-Prot),   A0A8I6AN12 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000011834   ⟸   ENSRNOT00000011808
Ensembl Acc Id: ENSRNOP00000094907   ⟸   ENSRNOT00000112106
RefSeq Acc Id: XP_063125715   ⟸   XM_063269645
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125714   ⟸   XM_063269644
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125716   ⟸   XM_063269646
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063125713   ⟸   XM_063269643
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125711   ⟸   XM_063269641
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125710   ⟸   XM_063269640
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125712   ⟸   XM_063269642
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125709   ⟸   XM_063269639
- Peptide Label: isoform X2
- UniProtKB: A6HH68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125718   ⟸   XM_063269648
- Peptide Label: isoform X5
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSZ3-F1-model_v2 AlphaFold D3ZSZ3 1-527 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697489
Promoter ID:EPDNEW_R8013
Type:multiple initiation site
Name:Nlk_1
Description:nemo like kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01065,963,909 - 65,963,969EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561602 AgrOrtholog
BioCyc Gene G2FUF-24050 BioCyc
Ensembl Genes ENSRNOG00000008704 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030515 UniProtKB/Swiss-Prot
  ENSRNOG00060031673 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011726.7 UniProtKB/Swiss-Prot
  ENSRNOT00000112106.1 UniProtKB/TrEMBL
  ENSRNOT00055052946 UniProtKB/Swiss-Prot
  ENSRNOT00060054873 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:497961 UniProtKB/Swiss-Prot
NCBI Gene 497961 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE NLK UniProtKB/TrEMBL
  SIMILAR TO NEMO-LIKE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nlk PhenoGen
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008704 RatGTEx
  ENSRNOG00055030515 RatGTEx
  ENSRNOG00060031673 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AN12 ENTREZGENE, UniProtKB/TrEMBL
  A6HH68 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSZ3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Nlk  nemo like kinase  RGD1561602_predicted  similar to nemo like kinase (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561602_predicted  similar to nemo like kinase (predicted)  LOC497961  similar to nemo like kinase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC497961  similar to nemo like kinase      Symbol and Name status set to provisional 70820 PROVISIONAL