Dock8 (dedicator of cytokinesis 8) - Rat Genome Database

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Gene: Dock8 (dedicator of cytokinesis 8) Rattus norvegicus
Analyze
Symbol: Dock8
Name: dedicator of cytokinesis 8
RGD ID: 1561588
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including positive regulation of GTPase activity; positive regulation of T cell migration; and positive regulation of establishment of T cell polarity. Predicted to act upstream of or within several processes, including dendritic cell migration; immunological synapse formation; and memory T cell proliferation. Predicted to be located in cytosol and leading edge membrane. Predicted to be active in cell leading edge. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in atopic dermatitis; bacterial infectious disease; hyper IgE recurrent infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to human DOCK8 (dedicator of cytokinesis 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dedicator of cytokinesis protein 8; LOC499337; MGC116414; similar to dedicator of cytokinesis 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Dock8m1Ztm  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,075,468 - 232,268,830 (+)NCBIGRCr8
mRatBN7.21222,649,309 - 222,842,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,649,309 - 222,842,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1231,101,903 - 231,293,334 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01238,031,979 - 238,223,404 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01230,850,102 - 231,043,264 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01242,934,685 - 243,153,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,959,488 - 243,153,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,200,507 - 250,417,771 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,441,384 - 228,634,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1219,852,410 - 220,042,463 (+)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenfluramine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
inulin  (ISO)
L-methionine  (ISO)
levonorgestrel  (ISO)
lidocaine  (EXP)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. Al-Herz W, etal., Clin Immunol. 2012 Jun;143(3):266-72. doi: 10.1016/j.clim.2012.03.002. Epub 2012 Mar 30.
2. DOCK8 Deficiency Presenting as an IPEX-Like Disorder. Alroqi FJ, etal., J Clin Immunol. 2017 Nov;37(8):811-819. doi: 10.1007/s10875-017-0451-1. Epub 2017 Oct 23.
3. A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes. Arndt T, etal., Diabetologia. 2015 Dec;58(12):2800-9. doi: 10.1007/s00125-015-3757-7. Epub 2015 Sep 12.
4. Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: implications for pathogenesis and potential detection by newborn screening. Dasouki M, etal., Clin Immunol. 2011 Nov;141(2):128-32. doi: 10.1016/j.clim.2011.06.003. Epub 2011 Jun 21.
5. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. Engelhardt KR, etal., J Allergy Clin Immunol. 2015 Aug;136(2):402-12. doi: 10.1016/j.jaci.2014.12.1945. Epub 2015 Feb 25.
6. New Gene Variants Associated with the Risk of Chronic HBV Infection. Fan M, etal., Virol Sin. 2020 Aug;35(4):378-387. doi: 10.1007/s12250-020-00200-x. Epub 2020 Apr 15.
7. Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiency. Flesch IE, etal., Immunol Cell Biol. 2015 Jul;93(6):517-21. doi: 10.1038/icb.2015.32. Epub 2015 Mar 17.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Ten-year follow-up of a DOCK8-deficient child with features of systemic lupus erythematosus. Jouhadi Z, etal., Pediatrics. 2014 Nov;134(5):e1458-63. doi: 10.1542/peds.2013-1383.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Additional diverse findings expand the clinical presentation of DOCK8 deficiency. Sanal O, etal., J Clin Immunol. 2012 Aug;32(4):698-708. doi: 10.1007/s10875-012-9664-5. Epub 2012 Apr 4.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19946888   PMID:21969276   PMID:22006977   PMID:22461490   PMID:25713392   PMID:28028151  


Genomics

Comparative Map Data
Dock8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,075,468 - 232,268,830 (+)NCBIGRCr8
mRatBN7.21222,649,309 - 222,842,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,649,309 - 222,842,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1231,101,903 - 231,293,334 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01238,031,979 - 238,223,404 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01230,850,102 - 231,043,264 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01242,934,685 - 243,153,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,959,488 - 243,153,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,200,507 - 250,417,771 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,441,384 - 228,634,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1219,852,410 - 220,042,463 (+)NCBICelera
Cytogenetic Map1q51NCBI
DOCK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389211,257 - 465,255 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9214,854 - 465,259 (+)EnsemblGRCh38hg38GRCh38
GRCh379214,865 - 465,255 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369263,048 - 455,255 (+)NCBINCBI36Build 36hg18NCBI36
Celera9129,697 - 382,253 (+)NCBICelera
Cytogenetic Map9p24.3NCBI
HuRef9168,609 - 417,080 (+)NCBIHuRef
CHM1_19215,319 - 464,907 (+)NCBICHM1_1
T2T-CHM13v2.09208,892 - 464,924 (+)NCBIT2T-CHM13v2.0
Dock8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391924,976,753 - 25,179,796 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1924,976,898 - 25,179,796 (+)EnsemblGRCm39 Ensembl
GRCm381924,999,321 - 25,202,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1924,999,534 - 25,202,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv371925,074,019 - 25,276,922 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361925,066,626 - 25,269,529 (+)NCBIMGSCv36mm8
Celera1925,771,990 - 25,988,915 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1919.91NCBI
Dock8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554344,867,016 - 5,049,118 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554344,849,147 - 5,050,545 (+)NCBIChiLan1.0ChiLan1.0
DOCK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211124,121,179 - 124,370,714 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19124,127,121 - 124,376,660 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v096,791 - 256,837 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19201,156 - 446,910 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9201,156 - 446,910 (+)Ensemblpanpan1.1panPan2
DOCK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1189,152,456 - 89,379,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl189,150,856 - 89,378,013 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha189,621,978 - 89,850,471 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0189,701,521 - 89,930,127 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl189,700,853 - 89,928,963 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1189,347,665 - 89,576,215 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0189,059,801 - 89,288,656 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0189,820,804 - 90,055,669 (+)NCBIUU_Cfam_GSD_1.0
Dock8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947136,597,710 - 136,810,653 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365034,363,926 - 4,574,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365034,362,573 - 4,575,307 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,256,009 - 221,491,953 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,257,771 - 221,491,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,516,602 - 247,752,057 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11279,060,579 - 79,298,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1279,060,425 - 79,298,164 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603867,459,893 - 67,698,795 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247364,959,634 - 5,193,928 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247364,959,482 - 5,195,182 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dock8
1169 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:270
Count of miRNA genes:183
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000015668
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1207987464234238494Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1218108584224054420Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1207987464228627600Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1206329708222745518Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1207702246228581766Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1214537555226660468Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1207987464228627600Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat

Markers in Region
RH141900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,659,472 - 222,659,664 (+)MAPPERmRatBN7.2
Rnor_6.01242,969,648 - 242,969,839NCBIRnor6.0
Rnor_5.01250,235,226 - 250,235,417UniSTSRnor5.0
RGSC_v3.41228,451,548 - 228,451,739UniSTSRGSC3.4
Celera1219,862,574 - 219,862,765UniSTS
RH 3.4 Map11617.41UniSTS
Cytogenetic Map1q51UniSTS
AI071634  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,842,145 - 222,842,341 (+)MAPPERmRatBN7.2
Rnor_6.01243,153,141 - 243,153,336NCBIRnor6.0
Rnor_5.01250,417,440 - 250,417,635UniSTSRnor5.0
RGSC_v3.41228,634,389 - 228,634,584UniSTSRGSC3.4
Celera1220,042,135 - 220,042,330UniSTS
Cytogenetic Map1q51UniSTS
AA893933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,782,207 - 222,782,299 (+)MAPPERmRatBN7.2
Rnor_6.01243,092,985 - 243,093,076NCBIRnor6.0
Rnor_5.01250,357,732 - 250,357,823UniSTSRnor5.0
RGSC_v3.41228,573,819 - 228,573,910UniSTSRGSC3.4
Celera1219,984,243 - 219,984,334UniSTS
RH 3.4 Map11615.0UniSTS
Cytogenetic Map1q51UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015668   ⟹   ENSRNOP00000015668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,649,309 - 222,842,474 (+)Ensembl
Rnor_6.0 Ensembl1242,959,488 - 243,152,480 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1243,058,872 - 243,075,277 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1243,072,413 - 243,073,087 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1243,144,812 - 243,153,465 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1243,105,526 - 243,106,212 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1243,110,752 - 243,112,007 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1243,092,773 - 243,093,222 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101118   ⟹   ENSRNOP00000093314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,693,134 - 222,842,474 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110654   ⟹   ENSRNOP00000090874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,695,452 - 222,842,474 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119197   ⟹   ENSRNOP00000092756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,677,006 - 222,842,474 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120209   ⟹   ENSRNOP00000089814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,693,963 - 222,842,474 (+)Ensembl
RefSeq Acc Id: NM_001037793   ⟹   NP_001032882
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,075,677 - 232,268,830 (+)NCBI
mRatBN7.21222,649,309 - 222,842,474 (+)NCBI
Rnor_6.01242,959,484 - 243,153,469 (+)NCBI
Rnor_5.01250,200,507 - 250,417,771 (+)NCBI
RGSC_v3.41228,441,384 - 228,634,717 (+)RGD
Celera1219,852,410 - 220,042,463 (+)RGD
Sequence:
RefSeq Acc Id: XM_008760310   ⟹   XP_008758532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,120,790 - 232,268,830 (+)NCBI
mRatBN7.21222,694,414 - 222,842,474 (+)NCBI
Rnor_6.01242,934,685 - 243,153,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271698   ⟹   XP_063127768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,075,468 - 232,222,599 (+)NCBI
RefSeq Acc Id: NP_001032882   ⟸   NM_001037793
- UniProtKB: F1LPG2 (UniProtKB/TrEMBL),   A0A8I6A829 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758532   ⟸   XM_008760310
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015668   ⟸   ENSRNOT00000015668
Ensembl Acc Id: ENSRNOP00000093314   ⟸   ENSRNOT00000101118
Ensembl Acc Id: ENSRNOP00000092756   ⟸   ENSRNOT00000119197
Ensembl Acc Id: ENSRNOP00000089814   ⟸   ENSRNOT00000120209
Ensembl Acc Id: ENSRNOP00000090874   ⟸   ENSRNOT00000110654
RefSeq Acc Id: XP_063127768   ⟸   XM_063271698
- Peptide Label: isoform X2
Protein Domains
C2 DOCK-type   DOCKER

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LPG2-F1-model_v2 AlphaFold F1LPG2 1-2099 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690830
Promoter ID:EPDNEW_R1355
Type:multiple initiation site
Name:Dock8_1
Description:dedicator of cytokinesis 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1356  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01242,959,494 - 242,959,554EPDNEW
RGD ID:13690837
Promoter ID:EPDNEW_R1356
Type:single initiation site
Name:Dock8_2
Description:dedicator of cytokinesis 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1355  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01243,072,340 - 243,072,400EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561588 AgrOrtholog
BioCyc Gene G2FUF-56081 BioCyc
Ensembl Genes ENSRNOG00000015894 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015668.8 UniProtKB/TrEMBL
  ENSRNOT00000101118.1 UniProtKB/TrEMBL
  ENSRNOT00000110654.1 UniProtKB/TrEMBL
  ENSRNOT00000119197.1 UniProtKB/TrEMBL
  ENSRNOT00000120209.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_Dock-C UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DHR-2 UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_C/D_N UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
KEGG Report rno:499337 UniProtKB/TrEMBL
NCBI Gene 499337 ENTREZGENE
PANTHER DEDICATOR OF CYTOKINESIS PROTEIN 8 UniProtKB/TrEMBL
  PTHR23317 UniProtKB/TrEMBL
Pfam Ded_cyto UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DUF3398 UniProtKB/TrEMBL
PhenoGen Dock8 PhenoGen
PROSITE DHR_1 UniProtKB/TrEMBL
  DHR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015894 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I6A829 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIT9_RAT UniProtKB/TrEMBL
  A0A8I6AK46_RAT UniProtKB/TrEMBL
  A0A8I6GJ78 ENTREZGENE, UniProtKB/TrEMBL
  F1LPG2 ENTREZGENE, UniProtKB/TrEMBL
  Q4KLF9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Dock8  dedicator of cytokinesis 8  LOC499337  similar to dedicator of cytokinesis 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC499337  similar to dedicator of cytokinesis 8      Symbol and Name status set to provisional 70820 PROVISIONAL