MIR27B (microRNA mir-27b) - Rat Genome Database

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Gene: MIR27B (microRNA mir-27b) Sus scrofa
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Symbol: MIR27B
Name: microRNA mir-27b (Ensembl:microRNA 27b)
RGD ID: 14141498
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 27b; ssc-mir-27b
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,079,954 - 27,080,056 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11027,079,963 - 27,080,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,340,880 - 31,340,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to leukemia inhibitory factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cholesterol homeostasis  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
myelination  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of cholesterol metabolic process  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of myofibroblast differentiation  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (ISO)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell adhesion involved in sprouting angiogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of gene expression  (ISO)
regulation of semaphorin-plexin signaling pathway  (ISO)
regulation of superoxide metabolic process  (ISO)
response to angiotensin  (ISO)
response to bacterium  (ISO)
response to muscle activity  (ISO)
retina vasculature development in camera-type eye  (ISO)
sensory perception of sound  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:19917043   PMID:20180025   PMID:21312241   PMID:24499489   PMID:27638309   PMID:29734192   PMID:31230206  


Genomics

Comparative Map Data
MIR27B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,079,954 - 27,080,056 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11027,079,963 - 27,080,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,340,880 - 31,340,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIR27B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38995,085,445 - 95,085,541 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl995,085,445 - 95,085,541 (+)Ensemblhg38GRCh38
GRCh37997,847,727 - 97,847,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,887,547 - 96,887,643 (+)NCBIBuild 36Build 36hg18NCBI36
Celera968,288,758 - 68,288,854 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef967,457,280 - 67,457,376 (+)NCBIHuRef
CHM1_1997,994,205 - 97,994,301 (+)NCBICHM1_1
T2T-CHM13v2.09107,254,838 - 107,254,934 (+)NCBIT2T-CHM13v2.0
Mir27b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391363,448,526 - 63,448,598 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1363,448,526 - 63,448,598 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381363,300,712 - 63,300,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1363,300,712 - 63,300,784 (+)Ensemblmm10GRCm38
MGSCv371363,402,020 - 63,402,092 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1364,954,893 - 64,954,965 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1332.8NCBI
Mir27b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8171,819,147 - 1,819,243 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2171,813,427 - 1,813,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,813,426 - 1,813,529 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx171,832,126 - 1,832,222 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0173,374,724 - 3,374,820 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0171,829,576 - 1,829,672 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.017823,461 - 823,557 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17823,461 - 823,557 (+)Ensemblrn6Rnor6.0
Rnor_5.017816,274 - 816,370 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera17709,223 - 709,319 (+)NCBICelera
Cytogenetic Map17p14NCBI
MIR27B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1171,678,117 - 71,678,179 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl171,678,105 - 71,678,191 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha172,440,078 - 72,440,140 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0171,982,476 - 71,982,538 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl171,982,464 - 71,982,550 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1171,793,881 - 71,793,943 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0171,557,950 - 71,558,012 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0172,264,234 - 72,264,296 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 3 23 3 4 14 11 23 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000020954
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1027,079,954 - 27,080,056 (-)Ensembl
RefSeq Acc Id: NR_038536
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11027,079,963 - 27,080,042 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000019359 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000020954 ENTREZGENE
miRBase MI0013109 ENTREZGENE
NCBI Gene MIR27B ENTREZGENE
RNAcentral URS000059311D RNACentral
  URS000075E684 RNACentral
  URS000075EA7B RNACentral
  URS0000CC78B7 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR27B  microRNA mir-27b    microRNA 27b  Symbol and/or name change 5135510 APPROVED