Rhobtb3 (Rho-related BTB domain containing 3) - Rat Genome Database

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Gene: Rhobtb3 (Rho-related BTB domain containing 3) Rattus norvegicus
Analyze
Symbol: Rhobtb3
Name: Rho-related BTB domain containing 3
RGD ID: 1311683
Description: Predicted to enable ATP binding activity; ATP hydrolysis activity; and enzyme binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteolysis; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within male gonad development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC309922; rho-related BTB domain-containing protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr827,094,972 - 7,201,507 (-)NCBIGRCr8
mRatBN7.225,363,388 - 5,419,164 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl25,363,388 - 5,419,041 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx212,470,299 - 12,525,964 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0210,569,530 - 10,625,193 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.025,205,925 - 5,261,578 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.022,627,655 - 2,683,305 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl22,627,393 - 2,683,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.022,626,102 - 2,681,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.422,911,820 - 2,967,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.122,933,865 - 3,007,464 (-)NCBI
Celera21,833,192 - 1,888,641 (-)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
isotretinoin  (ISO)
leflunomide  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18570454   PMID:19490898   PMID:22709582   PMID:24923387  


Genomics

Comparative Map Data
Rhobtb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr827,094,972 - 7,201,507 (-)NCBIGRCr8
mRatBN7.225,363,388 - 5,419,164 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl25,363,388 - 5,419,041 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx212,470,299 - 12,525,964 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0210,569,530 - 10,625,193 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.025,205,925 - 5,261,578 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.022,627,655 - 2,683,305 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl22,627,393 - 2,683,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.022,626,102 - 2,681,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.422,911,820 - 2,967,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.122,933,865 - 3,007,464 (-)NCBI
Celera21,833,192 - 1,888,641 (-)NCBICelera
Cytogenetic Map2q11NCBI
RHOBTB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38595,717,624 - 95,796,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl595,713,522 - 95,824,383 (+)EnsemblGRCh38hg38GRCh38
GRCh37595,067,040 - 95,132,065 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36595,092,606 - 95,157,827 (+)NCBINCBI36Build 36hg18NCBI36
Build 34595,092,798 - 95,156,560NCBI
Celera590,945,592 - 91,010,810 (+)NCBICelera
Cytogenetic Map5q15NCBI
HuRef590,257,253 - 90,322,380 (+)NCBIHuRef
CHM1_1594,499,513 - 94,564,723 (+)NCBICHM1_1
T2T-CHM13v2.0596,232,572 - 96,297,590 (+)NCBIT2T-CHM13v2.0
Rhobtb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391376,017,656 - 76,092,054 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1376,017,656 - 76,092,044 (-)EnsemblGRCm39 Ensembl
GRCm381375,869,537 - 75,943,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1375,869,537 - 75,943,925 (-)EnsemblGRCm38mm10GRCm38
MGSCv371376,006,985 - 76,081,272 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361376,335,539 - 76,409,826 (-)NCBIMGSCv36mm8
Celera1378,189,914 - 78,265,316 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.95NCBI
Rhobtb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541816,772,363 - 16,839,347 (-)NCBIChiLan1.0ChiLan1.0
RHOBTB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2419,582,719 - 19,648,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1517,736,325 - 17,801,657 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0519,552,740 - 19,618,055 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1519,698,304 - 19,763,363 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl519,698,304 - 19,763,363 (-)Ensemblpanpan1.1panPan2
RHOBTB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1313,823,607 - 13,879,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl313,825,040 - 13,877,456 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha315,161,683 - 15,216,345 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0313,702,408 - 13,757,171 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl313,702,203 - 13,757,142 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1313,665,317 - 13,719,938 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0313,662,275 - 13,717,986 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0313,862,251 - 13,916,923 (-)NCBIUU_Cfam_GSD_1.0
Rhobtb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213169,374,619 - 169,432,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365237,559,335 - 7,617,786 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365237,562,054 - 7,618,380 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOBTB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2102,334,741 - 102,394,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12102,334,747 - 102,395,134 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22106,219,692 - 106,280,134 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RHOBTB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1489,605,801 - 89,670,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl489,606,204 - 89,670,669 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604938,251,332 - 38,316,159 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhobtb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474314,361,573 - 14,424,063 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rhobtb3
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:534
Count of miRNA genes:260
Interacting mature miRNAs:309
Transcripts:ENSRNOT00000016838
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat

Markers in Region
RH143666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.225,363,406 - 5,363,516 (+)MAPPERmRatBN7.2
Rnor_6.022,627,674 - 2,627,783NCBIRnor6.0
Rnor_5.022,626,121 - 2,626,230UniSTSRnor5.0
RGSC_v3.422,911,839 - 2,911,948UniSTSRGSC3.4
Celera21,833,211 - 1,833,320UniSTS
Cytogenetic Map2q11UniSTS
AU046895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.225,409,228 - 5,409,415 (+)MAPPERmRatBN7.2
Rnor_6.022,673,493 - 2,673,679NCBIRnor6.0
Rnor_5.022,671,940 - 2,672,126UniSTSRnor5.0
RGSC_v3.422,957,661 - 2,957,847UniSTSRGSC3.4
Celera21,878,829 - 1,879,015UniSTS
Cytogenetic Map2q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016838   ⟹   ENSRNOP00000016838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl25,363,388 - 5,419,041 (-)Ensembl
Rnor_6.0 Ensembl22,627,393 - 2,683,116 (-)Ensembl
RefSeq Acc Id: NM_001107645   ⟹   NP_001101115
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,095,253 - 7,150,906 (-)NCBI
mRatBN7.225,363,388 - 5,419,041 (-)NCBI
Rnor_6.022,627,655 - 2,683,305 (-)NCBI
Rnor_5.022,626,102 - 2,681,752 (-)NCBI
RGSC_v3.422,911,820 - 2,967,473 (-)RGD
Celera21,833,192 - 1,888,641 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102150   ⟹   XP_038958078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,107,712 - 7,151,180 (-)NCBI
mRatBN7.225,375,847 - 5,419,164 (-)NCBI
RefSeq Acc Id: XM_063281692   ⟹   XP_063137762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,094,972 - 7,201,507 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101115 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958078 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137762 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09910 (Get FASTA)   NCBI Sequence Viewer  
  EDM09911 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016838.5
RefSeq Acc Id: NP_001101115   ⟸   NM_001107645
- UniProtKB: D3ZW90 (UniProtKB/TrEMBL),   A6I4F2 (UniProtKB/TrEMBL),   A6I4F3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016838   ⟸   ENSRNOT00000016838
RefSeq Acc Id: XP_038958078   ⟸   XM_039102150
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137762   ⟸   XM_063281692
- Peptide Label: isoform X2
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZW90-F1-model_v2 AlphaFold D3ZW90 1-611 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691033
Promoter ID:EPDNEW_R1558
Type:multiple initiation site
Name:Rhobtb3_1
Description:Rho-related BTB domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.022,683,039 - 2,683,099EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311683 AgrOrtholog
BioCyc Gene G2FUF-55089 BioCyc
Ensembl Genes ENSRNOG00000012414 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016838.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report rno:309922 UniProtKB/TrEMBL
NCBI Gene 309922 ENTREZGENE
PANTHER RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
  SPECKLE-TYPE POZ PROTEIN UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  Ras UniProtKB/TrEMBL
PhenoGen Rhobtb3 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012414 RatGTEx
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A6I4F2 ENTREZGENE, UniProtKB/TrEMBL
  A6I4F3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZW90 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Rhobtb3  Rho-related BTB domain containing 3   Rhobtb3_predicted  Rho-related BTB domain containing 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rhobtb3_predicted  Rho-related BTB domain containing 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED