Nudt14 (nudix hydrolase 14) - Rat Genome Database

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Gene: Nudt14 (nudix hydrolase 14) Rattus norvegicus
Analyze
Symbol: Nudt14
Name: nudix hydrolase 14
RGD ID: 1310583
Description: Predicted to enable ADP-ribose diphosphatase activity; UDP-sugar diphosphatase activity; and identical protein binding activity. Predicted to be involved in nucleoside phosphate metabolic process and ribose phosphate metabolic process. Orthologous to human NUDT14 (nudix hydrolase 14); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299346; nudix (nucleoside diphosphate linked moiety X)-type motif 14; nudix-type motif 14; uridine diphosphate glucose pyrophosphatase; uridine diphosphate glucose pyrophosphatase NUDT14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,831,382 - 137,838,370 (-)NCBIGRCr8
mRatBN7.26132,010,309 - 132,017,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,010,297 - 132,017,298 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,179,990 - 132,187,011 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,469,750 - 132,476,773 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,844,677 - 131,851,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,738,150 - 137,745,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,738,124 - 137,745,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,734,337 - 146,741,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,935,992 - 137,942,980 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,942,177 - 137,949,130 (-)NCBI
Celera6129,548,189 - 129,555,177 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19896456   PMID:23376485   PMID:25416956   PMID:31515488  


Genomics

Comparative Map Data
Nudt14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,831,382 - 137,838,370 (-)NCBIGRCr8
mRatBN7.26132,010,309 - 132,017,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,010,297 - 132,017,298 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,179,990 - 132,187,011 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,469,750 - 132,476,773 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,844,677 - 131,851,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,738,150 - 137,745,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,738,124 - 137,745,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,734,337 - 146,741,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,935,992 - 137,942,980 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,942,177 - 137,949,130 (-)NCBI
Celera6129,548,189 - 129,555,177 (-)NCBICelera
Cytogenetic Map6q32NCBI
NUDT14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,172,939 - 105,181,312 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,172,938 - 105,181,323 (-)EnsemblGRCh38hg38GRCh38
GRCh3714105,639,276 - 105,647,649 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,710,321 - 104,718,685 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414104,710,321 - 104,718,685NCBI
Celera1485,692,507 - 85,700,860 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,831,085 - 85,839,440 (-)NCBIHuRef
CHM1_114105,577,035 - 105,585,421 (-)NCBICHM1_1
T2T-CHM13v2.01499,414,864 - 99,423,206 (-)NCBIT2T-CHM13v2.0
Nudt14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,897,911 - 112,905,762 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,897,911 - 112,905,744 (-)EnsemblGRCm39 Ensembl
GRCm3812112,934,291 - 112,942,142 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,934,291 - 112,942,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,172,944 - 114,180,329 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,382,541 - 113,389,926 (-)NCBIMGSCv36mm8
Celera12114,145,321 - 114,152,146 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.42NCBI
Nudt14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,444,591 - 3,450,194 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,444,498 - 3,450,396 (-)NCBIChiLan1.0ChiLan1.0
NUDT14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,352,997 - 106,361,331 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,569,499 - 105,577,835 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,816,561 - 85,824,887 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,600,783 - 105,608,697 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,600,783 - 105,605,538 (-)Ensemblpanpan1.1panPan2
NUDT14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,562,314 - 72,568,542 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,562,314 - 72,567,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha872,074,078 - 72,080,968 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,849,806 - 72,856,744 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,822,931 - 72,856,860 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,530,342 - 72,537,214 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,581,473 - 72,588,360 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,971,347 - 72,978,237 (-)NCBIUU_Cfam_GSD_1.0
Nudt14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,517,696 - 1,525,057 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621346,479 - 354,042 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621346,463 - 354,014 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUDT14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,249,502 - 131,253,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103229796
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,082,072 - 83,090,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2483,081,793 - 83,090,316 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366650042,686 - 50,979 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nudt14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734298,357 - 304,048 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624734288,223 - 304,136 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nudt14
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:61
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000019550
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019550   ⟹   ENSRNOP00000019550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6132,010,309 - 132,017,298 (-)Ensembl
Rnor_6.0 Ensembl6137,738,124 - 137,745,127 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096617   ⟹   ENSRNOP00000097775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6132,010,614 - 132,017,298 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109846   ⟹   ENSRNOP00000081681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6132,010,297 - 132,017,027 (-)Ensembl
RefSeq Acc Id: NM_001106760   ⟹   NP_001100230
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,831,382 - 137,838,370 (-)NCBI
mRatBN7.26132,010,309 - 132,017,298 (-)NCBI
Rnor_6.06137,738,155 - 137,745,143 (-)NCBI
Rnor_5.06146,734,337 - 146,741,325 (-)NCBI
RGSC_v3.46137,935,992 - 137,942,980 (-)RGD
Celera6129,548,189 - 129,555,177 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100230 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97410 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019550.5
  ENSRNOP00000081681.1
  ENSRNOP00000097775.1
RefSeq Acc Id: NP_001100230   ⟸   NM_001106760
- UniProtKB: D4A1D4 (UniProtKB/TrEMBL),   A6KBX1 (UniProtKB/TrEMBL),   A0A8I6G8A4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019550   ⟸   ENSRNOT00000019550
Ensembl Acc Id: ENSRNOP00000097775   ⟸   ENSRNOT00000096617
Ensembl Acc Id: ENSRNOP00000081681   ⟸   ENSRNOT00000109846
Protein Domains
Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1D4-F1-model_v2 AlphaFold D4A1D4 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694858
Promoter ID:EPDNEW_R5381
Type:multiple initiation site
Name:Nudt14_1
Description:nudix hydrolase 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06137,745,116 - 137,745,176EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310583 AgrOrtholog
BioCyc Gene G2FUF-35769 BioCyc
Ensembl Genes ENSRNOG00000014362 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019550.7 UniProtKB/TrEMBL
  ENSRNOT00000096617.1 UniProtKB/TrEMBL
  ENSRNOT00000109846.1 UniProtKB/TrEMBL
Gene3D-CATH Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/TrEMBL
InterPro NDP_pyrophosphatase UniProtKB/TrEMBL
  NUDIX_hydrolase_dom UniProtKB/TrEMBL
  NUDIX_hydrolase_dom-like UniProtKB/TrEMBL
KEGG Report rno:299346 UniProtKB/TrEMBL
NCBI Gene 299346 ENTREZGENE
PANTHER UDP/ADP-SUGAR PYROPHOSPHATASE UniProtKB/TrEMBL
  URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14 UniProtKB/TrEMBL
Pfam NUDIX UniProtKB/TrEMBL
PhenoGen Nudt14 PhenoGen
PROSITE NUDIX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014362 RatGTEx
Superfamily-SCOP NUDIX_hydrolase UniProtKB/TrEMBL
UniProt A0A8I6ANQ4_RAT UniProtKB/TrEMBL
  A0A8I6G8A4 ENTREZGENE, UniProtKB/TrEMBL
  A6KBX1 ENTREZGENE, UniProtKB/TrEMBL
  D4A1D4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Nudt14  nudix hydrolase 14  Nudt14  nudix (nucleoside diphosphate linked moiety X)-type motif 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nudt14  nudix (nucleoside diphosphate linked moiety X)-type motif 14   Nudt14_predicted  nudix (nucleoside diphosphate linked moiety X)-type motif 14 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nudt14_predicted  nudix (nucleoside diphosphate linked moiety X)-type motif 14 (predicted)      Symbol and Name status set to approved 70820 APPROVED