Nxn (nucleoredoxin) - Rat Genome Database

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Gene: Nxn (nucleoredoxin) Rattus norvegicus
Analyze
Symbol: Nxn
Name: nucleoredoxin
RGD ID: 1310489
Description: Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in several processes, including Wnt signaling pathway; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Predicted to act upstream of or within cellular oxidant detoxification and in utero embryonic development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome 2. Orthologous to human NXN (nucleoredoxin); INTERACTS WITH 1,3-dinitrobenzene; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360577
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81061,607,557 - 61,745,807 (-)NCBIGRCr8
mRatBN7.21061,109,322 - 61,247,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1061,110,020 - 61,248,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,751,867 - 65,893,235 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01065,257,315 - 65,398,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,727,671 - 60,868,987 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01064,411,710 - 64,550,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1064,412,833 - 64,550,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01063,464,225 - 63,602,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41067,775,938 - 67,913,018 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11067,789,548 - 67,927,072 (+)NCBI
Celera1060,125,836 - 60,262,704 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E,E)-2,4-hexadienal  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lutein  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
N-nitrosodiethylamine  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9119370   PMID:20970343   PMID:27996060   PMID:29276006  


Genomics

Comparative Map Data
Nxn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81061,607,557 - 61,745,807 (-)NCBIGRCr8
mRatBN7.21061,109,322 - 61,247,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1061,110,020 - 61,248,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,751,867 - 65,893,235 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01065,257,315 - 65,398,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,727,671 - 60,868,987 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01064,411,710 - 64,550,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1064,412,833 - 64,550,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01063,464,225 - 63,602,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41067,775,938 - 67,913,018 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11067,789,548 - 67,927,072 (+)NCBI
Celera1060,125,836 - 60,262,704 (-)NCBICelera
Cytogenetic Map10q24NCBI
NXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3817799,310 - 979,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl17799,310 - 979,776 (-)EnsemblGRCh38hg38GRCh38
GRCh3717702,550 - 883,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3617649,335 - 829,760 (-)NCBINCBI36Build 36hg18NCBI36
Build 3417649,334 - 829,760NCBI
Celera17714,726 - 894,595 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef17612,981 - 789,470 (-)NCBIHuRef
CHM1_117711,357 - 891,770 (-)NCBICHM1_1
T2T-CHM13v2.017685,572 - 866,169 (-)NCBIT2T-CHM13v2.0
Nxn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391176,148,052 - 76,289,967 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1176,148,024 - 76,289,966 (-)EnsemblGRCm39 Ensembl
GRCm381176,257,226 - 76,399,141 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1176,257,198 - 76,399,140 (-)EnsemblGRCm38mm10GRCm38
MGSCv371176,070,728 - 76,212,643 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,074,153 - 76,215,336 (-)NCBIMGSCv36mm8
Celera1183,770,072 - 83,910,908 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Nxn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554812,338,445 - 2,481,557 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554812,338,005 - 2,481,557 (-)NCBIChiLan1.0ChiLan1.0
NXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,348,844 - 8,533,378 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11710,320,098 - 10,504,511 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v017769,179 - 946,981 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.117690,089 - 720,659 (-)NCBIpanpan1.1PanPan1.1panPan2
NXN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1944,847,468 - 45,003,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl944,847,558 - 44,998,906 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha943,998,054 - 44,150,808 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0945,664,165 - 45,818,376 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl945,664,254 - 45,816,996 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1944,443,986 - 44,597,122 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0944,729,843 - 44,890,725 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0944,816,642 - 44,969,467 (+)NCBIUU_Cfam_GSD_1.0
Nxn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,010,042 - 44,116,920 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365386,966,296 - 6,995,691 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1246,904,407 - 47,075,432 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11246,909,175 - 47,075,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,205,888 - 49,239,692 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116543,375 - 717,671 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605921,373,073 - 21,542,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nxn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247863,372,796 - 3,515,142 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247863,373,533 - 3,516,592 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nxn
730 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:103
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000050232
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Rat243  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,248,303 - 61,248,527 (+)MAPPERmRatBN7.2
Rnor_6.01064,550,912 - 64,551,135NCBIRnor6.0
Rnor_5.01063,463,237 - 63,463,460UniSTSRnor5.0
RGSC_v3.41067,774,947 - 67,775,171RGDRGSC3.4
RGSC_v3.41067,774,948 - 67,775,171UniSTSRGSC3.4
RGSC_v3.11067,788,570 - 67,788,794RGD
Celera1060,263,471 - 60,263,702UniSTS
SHRSP x BN Map1045.3799RGD
SHRSP x BN Map1045.3799UniSTS
Cytogenetic Map10q26UniSTS
D11Bhm34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,112,906 - 61,113,030 (+)MAPPERmRatBN7.2
Rnor_6.01064,415,294 - 64,415,417NCBIRnor6.0
Rnor_5.01063,598,955 - 63,599,078UniSTSRnor5.0
RGSC_v3.41067,910,434 - 67,910,557UniSTSRGSC3.4
Celera1060,128,297 - 60,128,420UniSTS
Cytogenetic Map10q26UniSTS
BE118869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,156,882 - 61,157,034 (+)MAPPERmRatBN7.2
Rnor_6.01064,459,266 - 64,459,417NCBIRnor6.0
Rnor_5.01063,554,955 - 63,555,106UniSTSRnor5.0
RGSC_v3.41067,866,434 - 67,866,585UniSTSRGSC3.4
Celera1060,172,171 - 60,172,322UniSTS
Cytogenetic Map10q26UniSTS
D11Bhm36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,146,484 - 61,146,645 (+)MAPPERmRatBN7.2
Rnor_6.01064,448,869 - 64,449,029NCBIRnor6.0
Rnor_5.01063,565,343 - 63,565,503UniSTSRnor5.0
RGSC_v3.41067,876,822 - 67,876,982UniSTSRGSC3.4
Celera1060,161,774 - 60,161,934UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000050232   ⟹   ENSRNOP00000047264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,110,429 - 61,247,522 (-)Ensembl
Rnor_6.0 Ensembl1064,412,833 - 64,550,145 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114535   ⟹   ENSRNOP00000085662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,110,020 - 61,248,251 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118517   ⟹   ENSRNOP00000082978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,110,020 - 61,118,011 (-)Ensembl
RefSeq Acc Id: NM_001399571   ⟹   NP_001386500
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,607,557 - 61,745,807 (-)NCBI
mRatBN7.21061,109,322 - 61,247,578 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386500 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05259 (Get FASTA)   NCBI Sequence Viewer  
  EDM05260 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047264.4
  ENSRNOP00000082978.1
  ENSRNOP00000085662.1
Ensembl Acc Id: ENSRNOP00000047264   ⟸   ENSRNOT00000050232
Ensembl Acc Id: ENSRNOP00000085662   ⟸   ENSRNOT00000114535
Ensembl Acc Id: ENSRNOP00000082978   ⟸   ENSRNOT00000118517
RefSeq Acc Id: NP_001386500   ⟸   NM_001399571
- UniProtKB: A0A8I6A4C2 (UniProtKB/TrEMBL)
Protein Domains
Thioredoxin   Thioredoxin-like fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0M2-F1-model_v2 AlphaFold D4A0M2 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697455
Promoter ID:EPDNEW_R7979
Type:initiation region
Name:Nxn_1
Description:nucleoredoxin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01064,550,186 - 64,550,246EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310489 AgrOrtholog
BioCyc Gene G2FUF-24159 BioCyc
Ensembl Genes ENSRNOG00000008178 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050232.4 UniProtKB/TrEMBL
  ENSRNOT00000114535.1 UniProtKB/TrEMBL
  ENSRNOT00000118517.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro NRX_PDI_b' UniProtKB/TrEMBL
  Thioredoxin-like_fold UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
  TryX_NRX_thioredoxin_dom UniProtKB/TrEMBL
NCBI Gene 360577 ENTREZGENE
PANTHER NUCLEOREDOXIN UniProtKB/TrEMBL
  NUCLEOREDOXIN UniProtKB/TrEMBL
Pfam Thioredoxin_6 UniProtKB/TrEMBL
  Thioredoxin_8 UniProtKB/TrEMBL
PhenoGen Nxn PhenoGen
PROSITE THIOREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008178 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A0A8I5ZZ00_RAT UniProtKB/TrEMBL
  A0A8I6A4C2 ENTREZGENE, UniProtKB/TrEMBL
  A6HGV4_RAT UniProtKB/TrEMBL
  D4A0M2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Nxn  nucleoredoxin   Nxn_predicted  nucleoredoxin (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nxn_predicted  nucleoredoxin (predicted)      Symbol and Name status set to approved 70820 APPROVED