Cpeb1 (cytoplasmic polyadenylation element binding protein 1) - Rat Genome Database

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Gene: Cpeb1 (cytoplasmic polyadenylation element binding protein 1) Rattus norvegicus
Analyze
Symbol: Cpeb1
Name: cytoplasmic polyadenylation element binding protein 1
RGD ID: 1310421
Description: Enables mRNA 3'-UTR binding activity. Involved in several processes, including cellular response to lipopolysaccharide; mRNA transport; and regulation of macromolecule biosynthetic process. Located in several cellular components, including centrosome; growth cone; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Used to study glioblastoma. Biomarker of portal hypertension and primary biliary cholangitis. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1); INTERACTS WITH 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CPE-binding protein 1; CPE-BP1; CPEB; CPEB-1; cytoplasmic polyadenylation element-binding protein 1; LOC293056
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,709,278 - 144,817,388 (-)NCBIGRCr8
mRatBN7.21135,300,048 - 135,407,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,300,461 - 135,409,760 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1143,215,210 - 143,321,813 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01150,384,623 - 150,491,225 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,297,567 - 143,404,159 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,171,457 - 143,278,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,171,264 - 143,278,485 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01144,114,219 - 144,220,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,556,766 - 137,666,929 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,635,181 - 137,745,334 (-)NCBI
Celera1127,351,540 - 127,457,741 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease. Calderone V, etal., Gastroenterology. 2016 Apr;150(4):982-97.e30. doi: 10.1053/j.gastro.2015.11.038. Epub 2015 Nov 26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Facilitation of dendritic mRNA transport by CPEB. Huang YS, etal., Genes Dev. 2003 Mar 1;17(5):638-53.
4. CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes. Kim KC, etal., Biochem Biophys Res Commun. 2011 Jun 17;409(4):687-92. doi: 10.1016/j.bbrc.2011.05.065. Epub 2011 May 17.
5. Cyclin B1 expression regulated by cytoplasmic polyadenylation element binding protein in astrocytes. Kim KC, etal., J Neurosci. 2011 Aug 24;31(34):12118-28. doi: 10.1523/JNEUROSCI.1621-11.2011.
6. CPEB1 regulates the expression of MTDH/AEG-1 and glioblastoma cell migration. Kochanek DM and Wells DG, Mol Cancer Res. 2013 Feb;11(2):149-60. doi: 10.1158/1541-7786.MCR-12-0498. Epub 2013 Jan 29.
7. Cytoplasmic polyadenylation element-binding protein regulates neurotrophin-3-dependent beta-catenin mRNA translation in developing hippocampal neurons. Kundel M, etal., J Neurosci. 2009 Oct 28;29(43):13630-9. doi: 10.1523/JNEUROSCI.2910-08.2009.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons. Oe S and Yoneda Y, FEBS Lett. 2010 Aug 4;584(15):3424-30. doi: 10.1016/j.febslet.2010.06.040. Epub 2010 Jul 8.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Udagawa T, etal., Mol Cell. 2012 Jul 27;47(2):253-66. doi: 10.1016/j.molcel.2012.05.016. Epub 2012 Jun 21.
13. CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses. Wu L, etal., Neuron. 1998 Nov;21(5):1129-39.
Additional References at PubMed
PMID:11702780   PMID:12815066   PMID:15057822   PMID:15169862   PMID:16314516   PMID:17024188   PMID:18618654   PMID:18752464   PMID:20662813   PMID:20668163   PMID:20937770   PMID:22323716  
PMID:22917528   PMID:23824559   PMID:28383716   PMID:31253357   PMID:38616716  


Genomics

Comparative Map Data
Cpeb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,709,278 - 144,817,388 (-)NCBIGRCr8
mRatBN7.21135,300,048 - 135,407,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,300,461 - 135,409,760 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1143,215,210 - 143,321,813 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01150,384,623 - 150,491,225 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,297,567 - 143,404,159 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,171,457 - 143,278,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,171,264 - 143,278,485 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01144,114,219 - 144,220,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,556,766 - 137,666,929 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,635,181 - 137,745,334 (-)NCBI
Celera1127,351,540 - 127,457,741 (-)NCBICelera
Cytogenetic Map1q31NCBI
CPEB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381582,543,201 - 82,648,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1582,543,201 - 82,648,861 (-)EnsemblGRCh38hg38GRCh38
GRCh371583,211,951 - 83,317,546 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361581,009,006 - 81,113,783 (-)NCBINCBI36Build 36hg18NCBI36
Build 341581,009,640 - 81,094,275NCBI
Celera1561,263,397 - 61,367,744 (+)NCBICelera
Cytogenetic Map15q25.2NCBI
HuRef1559,482,509 - 59,586,909 (-)NCBIHuRef
CHM1_11582,953,574 - 83,058,345 (-)NCBICHM1_1
T2T-CHM13v2.01580,407,439 - 80,513,020 (-)NCBIT2T-CHM13v2.0
Cpeb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,996,774 - 81,105,207 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,996,774 - 81,105,213 (-)EnsemblGRCm39 Ensembl
GRCm38781,347,026 - 81,458,001 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl781,347,026 - 81,455,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv37788,492,329 - 88,599,562 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36781,220,956 - 81,328,189 (-)NCBIMGSCv36mm8
Celera778,752,617 - 78,860,054 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.71NCBI
Cpeb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541613,981,657 - 14,039,705 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541613,963,300 - 14,038,691 (+)NCBIChiLan1.0ChiLan1.0
CPEB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21673,237,912 - 73,342,404 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11577,398,584 - 77,503,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01562,949,264 - 63,053,994 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11580,443,096 - 80,546,163 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1580,443,096 - 80,526,948 (-)Ensemblpanpan1.1panPan2
CPEB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1354,405,140 - 54,499,614 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl354,405,717 - 54,500,221 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,046,122 - 57,140,348 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0354,824,324 - 54,918,693 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl354,824,563 - 54,919,282 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1354,344,656 - 54,439,210 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0354,553,850 - 54,648,105 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,896,337 - 54,990,718 (-)NCBIUU_Cfam_GSD_1.0
Cpeb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640129,039,489 - 129,118,232 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648317,216,213 - 17,294,534 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648317,216,288 - 17,296,430 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPEB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,304,472 - 52,383,732 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,329,054 - 52,382,408 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2757,815,438 - 57,867,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPEB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1293,005,891 - 3,106,732 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl293,006,532 - 3,106,793 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605943,983,927 - 44,084,653 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpeb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476818,386,415 - 18,468,879 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpeb1
403 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:528
Count of miRNA genes:256
Interacting mature miRNAs:297
Transcripts:ENSRNOT00000026009
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
RH131661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,326,864 - 135,327,083 (+)MAPPERmRatBN7.2
Rnor_6.01143,198,273 - 143,198,491NCBIRnor6.0
Rnor_5.01144,140,630 - 144,140,848UniSTSRnor5.0
RGSC_v3.41137,583,177 - 137,583,395UniSTSRGSC3.4
Celera1127,377,951 - 127,378,169UniSTS
RH 3.4 Map11087.1UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 43 113 65 64 33 25 33 6 184 91 93 43 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026009   ⟹   ENSRNOP00000026009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,300,461 - 135,385,210 (-)Ensembl
Rnor_6.0 Ensembl1143,171,870 - 143,278,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078789   ⟹   ENSRNOP00000073393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,300,461 - 135,409,760 (-)Ensembl
Rnor_6.0 Ensembl1143,172,762 - 143,256,817 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080925   ⟹   ENSRNOP00000072309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,300,461 - 135,406,321 (-)Ensembl
Rnor_6.0 Ensembl1143,171,264 - 143,256,591 (-)Ensembl
RefSeq Acc Id: NM_001106276   ⟹   NP_001099746
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,683 - 144,816,263 (-)NCBI
mRatBN7.21135,300,453 - 135,407,030 (-)NCBI
Rnor_6.01143,171,862 - 143,278,485 (-)NCBI
Rnor_5.01144,114,219 - 144,220,842 (-)NCBI
RGSC_v3.41137,556,766 - 137,666,929 (-)RGD
Celera1127,351,540 - 127,457,741 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759509   ⟹   XP_008757731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,816,327 (-)NCBI
mRatBN7.21135,300,048 - 135,406,486 (-)NCBI
Rnor_6.01143,171,457 - 143,278,418 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759510   ⟹   XP_008757732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,816,327 (-)NCBI
mRatBN7.21135,300,048 - 135,406,486 (-)NCBI
Rnor_6.01143,171,457 - 143,278,417 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588939   ⟹   XP_017444428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,816,327 (-)NCBI
mRatBN7.21135,300,048 - 135,406,486 (-)NCBI
Rnor_6.01143,171,457 - 143,278,418 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588940   ⟹   XP_017444429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,816,327 (-)NCBI
mRatBN7.21135,300,048 - 135,406,486 (-)NCBI
Rnor_6.01143,171,457 - 143,278,417 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105652   ⟹   XP_038961580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,816,668 (-)NCBI
mRatBN7.21135,300,048 - 135,407,358 (-)NCBI
RefSeq Acc Id: XM_039105656   ⟹   XP_038961584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,817,388 (-)NCBI
mRatBN7.21135,300,048 - 135,407,669 (-)NCBI
RefSeq Acc Id: XM_039105662   ⟹   XP_038961590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,817,388 (-)NCBI
mRatBN7.21135,300,048 - 135,407,688 (-)NCBI
RefSeq Acc Id: XM_039105664   ⟹   XP_038961592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,803,515 (-)NCBI
mRatBN7.21135,300,048 - 135,393,960 (-)NCBI
RefSeq Acc Id: XM_039105670   ⟹   XP_038961598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,816,173 (-)NCBI
mRatBN7.21135,300,048 - 135,406,486 (-)NCBI
RefSeq Acc Id: XM_039105676   ⟹   XP_038961604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,734,277 (-)NCBI
mRatBN7.21135,300,048 - 135,325,047 (-)NCBI
RefSeq Acc Id: XM_063284692   ⟹   XP_063140762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,815,470 (-)NCBI
RefSeq Acc Id: XM_063284698   ⟹   XP_063140768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,816,389 (-)NCBI
RefSeq Acc Id: XM_063284704   ⟹   XP_063140774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,815,548 (-)NCBI
RefSeq Acc Id: XM_063284707   ⟹   XP_063140777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,816,389 (-)NCBI
RefSeq Acc Id: XM_063284729   ⟹   XP_063140799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,817,387 (-)NCBI
RefSeq Acc Id: XM_063284737   ⟹   XP_063140807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,709,278 - 144,815,475 (-)NCBI
RefSeq Acc Id: NP_001099746   ⟸   NM_001106276
- UniProtKB: P0C279 (UniProtKB/Swiss-Prot),   A6JCF8 (UniProtKB/TrEMBL),   A0A8L2QE04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757732   ⟸   XM_008759510
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K5E3 (UniProtKB/TrEMBL),   A0A8L2QE04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757731   ⟸   XM_008759509
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QE04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444428   ⟸   XM_017588939
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QE04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444429   ⟸   XM_017588940
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QE04 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026009   ⟸   ENSRNOT00000026009
Ensembl Acc Id: ENSRNOP00000072309   ⟸   ENSRNOT00000080925
Ensembl Acc Id: ENSRNOP00000073393   ⟸   ENSRNOT00000078789
RefSeq Acc Id: XP_038961590   ⟸   XM_039105662
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QE04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961584   ⟸   XM_039105656
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QE04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961580   ⟸   XM_039105652
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QE04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961598   ⟸   XM_039105670
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038961592   ⟸   XM_039105664
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QE04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961604   ⟸   XM_039105676
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063140799   ⟸   XM_063284729
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063140777   ⟸   XM_063284707
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063140768   ⟸   XM_063284698
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063140774   ⟸   XM_063284704
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063140807   ⟸   XM_063284737
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063140762   ⟸   XM_063284692
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K2N1 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C279-F1-model_v2 AlphaFold P0C279 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310421 AgrOrtholog
BioCyc Gene G2FUF-58711 BioCyc
Ensembl Genes ENSRNOG00000019161 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026009.8 UniProtKB/TrEMBL
  ENSRNOT00000078789.2 UniProtKB/TrEMBL
  ENSRNOT00000080925.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.640.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CEBP1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CEBP_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CEBP_ZZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPEB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPEB1_RRM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:293056 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 293056 ENTREZGENE
PANTHER CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CEBP1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CEBP_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cpeb1 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019161 RatGTEx
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2N1 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QE04 ENTREZGENE, UniProtKB/TrEMBL
  A6JCF8 ENTREZGENE, UniProtKB/TrEMBL
  CPEB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cpeb1  cytoplasmic polyadenylation element binding protein 1   Cpeb1_predicted  cytoplasmic polyadenylation element binding protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cpeb1_predicted  cytoplasmic polyadenylation element binding protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED