Chuk (component of inhibitor of nuclear factor kappa B kinase complex) - Rat Genome Database

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Gene: Chuk (component of inhibitor of nuclear factor kappa B kinase complex) Rattus norvegicus
Analyze
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
RGD ID: 1306661
Description: Predicted to enable several functions, including protein dimerization activity; scaffold protein binding activity; and transferrin receptor binding activity. Predicted to contribute to IkappaB kinase activity. Involved in several processes, including response to acetate; response to cholecystokinin; and response to hydroperoxide. Part of IkappaB kinase complex. Used to study muscular atrophy. Biomarker of colitis. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH (+)-Tetrandrine; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: conserved helix-loop-helix ubiquitous kinase; Ikbka; Ikka; inhibitor of nuclear factor kappa-B kinase subunit alpha; LOC309361
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,908,748 - 252,944,273 (-)NCBIGRCr8
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,109,858 - 251,145,433 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,806,623 - 257,842,185 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,460,007 - 250,495,589 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Celera1238,777,027 - 238,812,551 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-Erythraline  (ISO)
(+)-Tetrandrine  (EXP)
(-)-Arctigenin  (ISO)
(-)-matairesinol  (ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-phenylprop-2-enal  (EXP)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-ribose  (ISO)
allyl methyl disulfide  (ISO)
alpinumisoflavone  (ISO)
Anemoside B4  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimony(0)  (ISO)
apigenin  (EXP)
Arctiin  (ISO)
aristolochic acid A  (ISO)
arjunolic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
auranofin  (ISO)
Aurothioglucose  (ISO)
benzo[a]pyrene  (ISO)
Berbamine  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celastrol  (EXP)
celecoxib  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
Crenigacestat  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-ribofuranose  (ISO)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (EXP,ISO)
dimethylarsinic acid  (EXP)
diquat  (EXP)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
etoposide  (ISO)
Evodiamine  (ISO)
filipin III  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
gallic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
ginsenoside Re  (ISO)
glutathione  (ISO)
graphene oxide  (ISO)
helenalin  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (ISO)
ionomycin  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
L-1,4-dithiothreitol  (ISO)
L-gamma-glutamyl-L-cysteine  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
melittin  (ISO)
melphalan  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
mevalonic acid  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N-dimethylformamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
Neferine  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nimesulide  (EXP)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
Paeonol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
phenobarbital  (ISO)
phenylbutazone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
resiquimod  (ISO)
resveratrol  (ISO)
rocaglamide  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SNX-2112  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
testosterone  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
thiopental  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
Tylophorine  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wedelolactone  (EXP)
Xanthorrhizol  (ISO)
Y-27632  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Increased IKKa expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors. Alameda JP, etal., PLoS One. 2011;6(7):e21984. doi: 10.1371/journal.pone.0021984. Epub 2011 Jul 6.
2. Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. An J, etal., Oncotarget. 2016 Aug 2;7(31):50131-50149. doi: 10.18632/oncotarget.10321.
3. Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. Bruno ME, etal., Arch Biochem Biophys. 2002 Oct 15;406(2):153-64.
4. Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation. Canicio J, etal., J Biol Chem. 2001 Jun 8;276(23):20228-33. Epub 2001 Mar 28.
5. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. Chung S, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L192-203. Epub 2010 May 14.
6. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
7. NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex. Fontan E, etal., FEBS J. 2007 May;274(10):2540-51. Epub 2007 Apr 10.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
11. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Ho RC, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C794-801. Epub 2005 May 11.
12. Activation mechanisms of endothelial NF-kappaB, IKK, and MAP kinase by tert-butyl hydroperoxide. Lee JY, etal., Free Radic Res. 2005 Apr;39(4):399-409.
13. CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. Lim JH, etal., Cell Microbiol. 2008 Nov;10(11):2247-56. Epub 2008 Jul 16.
14. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Luo JL, etal., Nature. 2007 Apr 5;446(7136):690-4. Epub 2007 Mar 18.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Park KA, etal., Carcinogenesis. 2007 Jan;28(1):71-80. doi: 10.1093/carcin/bgl094. Epub 2006 Jun 14.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha. Rattan R, etal., Free Radic Biol Med. 2003 Nov 1;35(9):1037-50.
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Apigenin blocks IKKa activation and suppresses prostate cancer progression. Shukla S, etal., Oncotarget. 2015 Oct 13;6(31):31216-32. doi: 10.18632/oncotarget.5157.
25. Suppression of NF-¿B and NF-¿B-Regulated Gene Expression by Apigenin through I¿Ba and IKK Pathway in TRAMP Mice. Shukla S, etal., PLoS One. 2015 Sep 17;10(9):e0138710. doi: 10.1371/journal.pone.0138710. eCollection 2015.
26. Suppression of NFkappaB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model. Siddiqui IA, etal., Pharm Res. 2008 Mar 4;.
27. Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules. Tando Y, etal., Digestion. 2002;66(4):237-45. doi: 10.1159/000068364.
28. The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. Van Gammeren D, etal., FASEB J. 2009 Feb;23(2):362-70. doi: 10.1096/fj.08-114249. Epub 2008 Sep 30.
29. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
30. Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase. Wu L, etal., J Hypertens. 2006 Jan;24(1):123-30.
Additional References at PubMed
PMID:9520446   PMID:11536016   PMID:11747812   PMID:12477932   PMID:14743216   PMID:14960276   PMID:15485831   PMID:15684432   PMID:16079150   PMID:19386987   PMID:20434986   PMID:20442316  
PMID:20614026   PMID:22982470   PMID:23016877   PMID:23091055   PMID:23487264   PMID:23776175   PMID:24784232   PMID:24928390   PMID:26514923   PMID:30341167   PMID:30988283   PMID:32746986  


Genomics

Comparative Map Data
Chuk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,908,748 - 252,944,273 (-)NCBIGRCr8
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,109,858 - 251,145,433 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,806,623 - 257,842,185 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,460,007 - 250,495,589 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Celera1238,777,027 - 238,812,551 (-)NCBICelera
Cytogenetic Map1q54NCBI
CHUK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,186,319 - 100,229,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,188,300 - 100,229,596 (-)EnsemblGRCh38hg38GRCh38
GRCh3710101,948,057 - 101,989,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,938,114 - 101,979,334 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410101,938,114 - 101,979,366NCBI
Celera1095,686,067 - 95,727,300 (-)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1095,577,055 - 95,618,304 (-)NCBIHuRef
CHM1_110102,232,811 - 102,274,037 (-)NCBICHM1_1
T2T-CHM13v2.010101,070,354 - 101,113,853 (-)NCBIT2T-CHM13v2.0
Chuk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,061,773 - 44,095,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,061,774 - 44,095,919 (-)EnsemblGRCm39 Ensembl
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,073,335 - 44,107,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBIMGSCv36mm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.71NCBI
Chuk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,067,203 - 6,102,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,066,026 - 6,102,066 (-)NCBIChiLan1.0ChiLan1.0
CHUK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,077,682 - 112,118,610 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,083,001 - 112,123,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,794,228 - 96,835,449 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,276,290 - 100,317,082 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,280,490 - 100,316,918 (-)Ensemblpanpan1.1panPan2
CHUK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,964,670 - 13,001,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,965,479 - 13,001,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,147,837 - 13,184,707 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,433,260 - 13,470,158 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,433,260 - 13,470,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,980,085 - 13,016,958 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,017,918 - 13,055,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,152,231 - 13,189,348 (-)NCBIUU_Cfam_GSD_1.0
Chuk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,995,060 - 34,039,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493663633,673 - 79,194 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493663633,933 - 78,990 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHUK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,315,141 - 111,351,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,316,178 - 111,351,669 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,757,214 - 120,854,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHUK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,219,374 - 93,263,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,219,383 - 93,262,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,717 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chuk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473712,022,419 - 12,052,131 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473712,022,081 - 12,052,128 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chuk
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:563
Count of miRNA genes:269
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000030782
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1223262787260522016Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat

Markers in Region
RH133833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,959,637 - 242,959,854 (+)MAPPERmRatBN7.2
Rnor_6.01263,848,928 - 263,849,144NCBIRnor6.0
Rnor_5.01271,293,920 - 271,294,136UniSTSRnor5.0
RGSC_v3.41249,158,055 - 249,158,271UniSTSRGSC3.4
Celera1238,777,125 - 238,777,341UniSTS
RH 3.4 Map11617.52UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000030782   ⟹   ENSRNOP00000034134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)Ensembl
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096055   ⟹   ENSRNOP00000095574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117849   ⟹   ENSRNOP00000080169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,964,114 - 242,994,755 (-)Ensembl
RefSeq Acc Id: NM_001107588   ⟹   NP_001101058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,908,749 - 252,944,273 (-)NCBI
mRatBN7.21242,959,540 - 242,995,065 (-)NCBI
Rnor_6.01263,848,830 - 263,884,354 (-)NCBI
Rnor_5.01271,293,821 - 271,329,346 (-)NCBI
RGSC_v3.41249,122,845 - 249,158,369 (+)RGD
Celera1238,777,027 - 238,812,551 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264605   ⟹   XP_063120675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,911,477 - 252,944,271 (-)NCBI
RefSeq Acc Id: XM_063264608   ⟹   XP_063120678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,908,748 - 252,944,020 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101058 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120675 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120678 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68905 (Get FASTA)   NCBI Sequence Viewer  
  EDL94272 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034134.4
  ENSRNOP00000080169.1
  ENSRNOP00000095574.1
RefSeq Acc Id: NP_001101058   ⟸   NM_001107588
- UniProtKB: A6JHE8 (UniProtKB/TrEMBL),   A0A8I6ANR6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034134   ⟸   ENSRNOT00000030782
Ensembl Acc Id: ENSRNOP00000095574   ⟸   ENSRNOT00000096055
Ensembl Acc Id: ENSRNOP00000080169   ⟸   ENSRNOT00000117849
RefSeq Acc Id: XP_063120678   ⟸   XM_063264608
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120675   ⟸   XM_063264605
- Peptide Label: isoform X1
- UniProtKB: B5DF32 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V926-F1-model_v2 AlphaFold G3V926 1-745 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690934
Promoter ID:EPDNEW_R1459
Type:initiation region
Name:Chuk_1
Description:conserved helix-loop-helix ubiquitous kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01263,884,331 - 263,884,391EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306661 AgrOrtholog
BioCyc Gene G2FUF-55612 BioCyc
Ensembl Genes ENSRNOG00000022485 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030782.5 UniProtKB/TrEMBL
  ENSRNOT00000096055.1 UniProtKB/TrEMBL
  ENSRNOT00000117849.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.250 UniProtKB/TrEMBL
  6.10.250.2110 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IKBKB_SDD UniProtKB/TrEMBL
  IKBKB_SDD_sf UniProtKB/TrEMBL
  IKK UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:309361 UniProtKB/TrEMBL
NCBI Gene 309361 ENTREZGENE
PANTHER IKB KINASE UniProtKB/TrEMBL
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam IKBKB_SDD UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Chuk PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022485 RatGTEx
SMART IKKbetaNEMObind UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZSH4_RAT UniProtKB/TrEMBL
  A0A8I6ANR6 ENTREZGENE, UniProtKB/TrEMBL
  A6JHE8 ENTREZGENE, UniProtKB/TrEMBL
  B5DF32 ENTREZGENE, UniProtKB/TrEMBL
  G3V926_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Chuk  component of inhibitor of nuclear factor kappa B kinase complex  Chuk  conserved helix-loop-helix ubiquitous kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Chuk  conserved helix-loop-helix ubiquitous kinase   Chuk_predicted  conserved helix-loop-helix ubiquitous kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Chuk_predicted  conserved helix-loop-helix ubiquitous kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED