Mcpt8l2 (mast cell protease 8-like 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mcpt8l2 (mast cell protease 8-like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mcpt8l2
Name: mast cell protease 8-like 2
RGD ID: 1302938
Description: PARTICIPATES IN Entamoebiasis pathway; renin-angiotensin cascade pathway; systemic lupus erythematosus pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mast cell protease 1-like 2; mcpt1l2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,718,389 - 33,731,960 (+)NCBIGRCr8GRCr8GRCr8
UTH_Rnor_SHR_Utx1531,594,221 - 31,597,174 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,741,422 - 32,744,375 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,983,833 - 30,986,786 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,622,126 - 34,625,079 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,622,123 - 34,625,121 (-)Ensemblrn6Rnor6.0
Rnor_5.01538,512,231 - 38,515,237 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,430,943 - 34,433,896 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,318,522 - 29,321,475 (+)NCBICelera
RGSC_v3.11534,446,653 - 34,449,511 (+)NCBI
Cytogenetic Map15p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Mcpt8l2
163 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000073555
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 37 50 91 90 59 25 59 4 188 81 32 33 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000073555   ⟹   ENSRNOP00000066083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,622,123 - 34,625,121 (-)Ensembl
RefSeq Acc Id: NM_001135010   ⟹   NP_001128482
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,718,481 - 33,721,434 (+)NCBI
Rnor_6.01534,622,126 - 34,625,079 (-)NCBI
Rnor_5.01538,512,231 - 38,515,237 (-)NCBI
RGSC_v3.41534,430,943 - 34,433,896 (+)RGD
Celera1529,318,522 - 29,321,475 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274542   ⟹   XP_063130612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,718,389 - 33,731,960 (+)NCBI
RefSeq Acc Id: XM_063274543   ⟹   XP_063130613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,729,678 - 33,731,960 (+)NCBI
RefSeq Acc Id: XM_063274544   ⟹   XP_063130614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,718,389 - 33,721,122 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001128482 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130612 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130613 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130614 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE48390 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073561
RefSeq Acc Id: NP_001128482   ⟸   NM_001135010
- Peptide Label: precursor
- UniProtKB: Q6IE58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066083   ⟸   ENSRNOT00000073555
RefSeq Acc Id: XP_063130612   ⟸   XM_063274542
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130614   ⟸   XM_063274544
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063130613   ⟸   XM_063274543
- Peptide Label: isoform X2
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R9B5-F1-model_v2 AlphaFold M0R9B5 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302938 AgrOrtholog
Ensembl Genes ENSRNOG00000031792 ENTREZGENE
  ENSRNOG00000049096 Ensembl
Ensembl Transcript ENSRNOT00000091167 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
NCBI Gene 408240 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/TrEMBL
  MAST CELL PROTEASE 8 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Mcpt8l2 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031792 RatGTEx
  ENSRNOG00000049096 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt Q6IE58 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-02-14 Mcpt8l2  mast cell protease 8-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL