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Gene: DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A) Canis lupus familiaris

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Symbol:

DYRK1A

Name:

dual specificity tyrosine phosphorylation regulated kinase 1A

RGD ID:

12137088

Description:

ENCODES a protein that exhibits actin binding (ortholog); cyclin binding (ortholog); cytoskeletal protein binding (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); cardiac muscle hypertrophy (ortholog); negative regulation of cell cycle (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); Cardiomegaly (ortholog); FOUND IN actin filament (ortholog); microtubule (ortholog); neurofilament (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

dual specificity tyrosine-phosphorylation-regulated kinase 1A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	32,564,970 - 32,655,232 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	32,511,502 - 32,652,572 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	31,572,154 - 31,719,378 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	31,812,898 - 31,959,979 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	31,811,351 - 31,960,042 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	31,682,502 - 31,829,001 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	31,695,751 - 31,842,602 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	32,186,102 - 32,332,696 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autosomal dominant intellectual developmental disorder 7 (ISO)

Cardiomegaly (ISO)

congestive heart failure (ISO)

developmental and epileptic encephalopathy 11 (ISO)

Developmental Disabilities (ISO)

dilated cardiomyopathy (ISO)

Down syndrome (ISO)

enophthalmos (ISO)

epilepsy (ISO)

Febrile Seizures (ISO)

generalized epilepsy (ISO)

genetic disease (ISO)

hyperhomocysteinemia (ISO)

intellectual disability (ISO)

microcephaly (ISO)

microphthalmia (ISO)

myocardial infarction (ISO)

Neurodevelopmental Disorders (ISO)

pancreatic cancer (ISO)

renovascular hypertension (ISO)

spermatogenic failure 5 (ISO)

sudden infant death syndrome (ISO)

tetralogy of Fallot (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcineurin-NFAT signaling cascade (ISO)

cardiac muscle hypertrophy (ISO)

chromatin remodeling (IEA)

circadian rhythm (IEA)

negative regulation of cell cycle (ISO)

negative regulation of DNA damage response, signal transduction by p53 class mediator (IEA)

negative regulation of gene expression (ISO)

negative regulation of heterochromatin formation (IEA)

negative regulation of microtubule polymerization (IEA)

negative regulation of mRNA splicing, via spliceosome (ISO)

negative regulation of protein phosphorylation (ISO)

peptidyl-serine phosphorylation (ISO)

peptidyl-tyrosine phosphorylation (ISO)

positive regulation of DNA-templated transcription (IBA)

positive regulation of double-strand break repair (IEA)

positive regulation of RNA splicing (IBA,IEA)

protein autophosphorylation (ISO)

protein import into nucleus (ISO)

protein phosphorylation (ISO)

regulation of alternative mRNA splicing, via spliceosome (ISO)

regulation of amyloid-beta formation (IEA)

regulation of cardiac muscle cell proliferation (ISO)

regulation of cell growth involved in cardiac muscle cell development (ISO)

regulation of neurofibrillary tangle assembly (IEA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

actin filament (ISO)

axon (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

dendrite (IEA)

microtubule (ISO)

neurofilament (ISO)

nuclear speck (IEA)

nucleolus (ISO)

nucleoplasm (IEA)

nucleus (IBA,IEA)

ribonucleoprotein complex (IEA)

Molecular Function

actin binding (ISO)

ATP binding (IEA)

cyclin binding (ISO)

cytoskeletal protein binding (ISO)

histone H3T45 kinase activity (IEA)

identical protein binding (IEA)

kinase activity (IEA)

non-membrane spanning protein tyrosine kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA)

protein serine/threonine/tyrosine kinase activity (IEA)

protein tyrosine kinase activity (IEA)

RNA polymerase II CTD heptapeptide repeat kinase activity (IEA)

splicing factor binding (ISO)

tau protein binding (IEA)

transcription coactivator activity (IBA)

transferase activity (IEA)

tubulin binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DYRK1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	32,564,970 - 32,655,232 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	32,511,502 - 32,652,572 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	31,572,154 - 31,719,378 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	31,812,898 - 31,959,979 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	31,811,351 - 31,960,042 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	31,682,502 - 31,829,001 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	31,695,751 - 31,842,602 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	32,186,102 - 32,332,696 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

DYRK1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	37,365,573 - 37,526,358 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	37,365,573 - 37,526,358 (+)	Ensembl			hg38	GRCh38
GRCh37	21	38,737,875 - 38,898,660 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	37,661,729 - 37,809,549 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	37,714,470 - 37,809,347	NCBI
Celera	21	23,938,247 - 24,086,068 (+)	NCBI		Celera
Cytogenetic Map	21	q22.13	NCBI
HuRef	21	24,215,875 - 24,363,782 (+)	NCBI		HuRef
CHM1_1	21	38,301,002 - 38,448,854 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	35,747,888 - 35,908,739 (+)	NCBI		T2T-CHM13v2.0

Dyrk1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	94,370,770 - 94,496,378 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	94,370,869 - 94,496,376 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	94,569,947 - 94,695,519 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	94,570,010 - 94,695,517 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	94,791,813 - 94,917,126 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	94,720,258 - 94,801,189 (+)	NCBI		MGSCv36	mm8
Celera	16	95,699,096 - 95,783,175 (+)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	55.3	NCBI

Dyrk1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	47,360,824 - 47,479,033 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	47,360,850 - 47,479,033 (+)	Ensembl				GRCr8
mRatBN7.2	11	33,890,706 - 34,009,420 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	33,890,490 - 34,009,420 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	42,573,541 - 42,666,554 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	35,244,902 - 35,337,921 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	34,390,728 - 34,483,971 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	34,858,339 - 34,958,733 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	34,865,532 - 34,956,536 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	38,453,019 - 38,550,512 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	34,879,733 - 34,970,998 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	34,444,072 - 34,535,020 (-)	NCBI		Celera
RGSC_v3.1	11	34,935,975 - 35,027,241 (+)	NCBI
Cytogenetic Map	11	q11	NCBI

Dyrk1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	36,453,098 - 36,589,382 (+)	Ensembl
ChiLan1.0	NW_004955407	36,456,628 - 36,588,940 (+)	NCBI	ChiLan1.0	ChiLan1.0

DYRK1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	33,475,597 - 33,629,787 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	28,339,782 - 28,489,307 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	23,729,204 - 23,878,820 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	37,092,172 - 37,231,916 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	37,137,253 - 37,231,987 (+)	Ensembl			panPan2	panpan1.1

Dyrk1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	32,044,360 - 32,150,716 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	5,316,164 - 5,404,353 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	5,317,109 - 5,423,593 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DYRK1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	201,009,480 - 201,159,948 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	201,008,506 - 201,159,946 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	211,096,538 - 211,247,962 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DYRK1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	81,318,509 - 81,467,227 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	81,425,902 - 81,467,677 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	9,164,197 - 9,315,412 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dyrk1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	26,180,864 - 26,315,234 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	26,180,858 - 26,316,848 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dyrk1a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	49,950,807 - 50,070,077 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in DYRK1A
678 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022413325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038443495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038443496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038443497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038461700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038461701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038461702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038517907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038517908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038517909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038581475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038581476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038581477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038645858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038645859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038645860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000003933 ⟹ ENSCAFP00000003635

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	31	32,511,502 - 32,646,626 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000015565 ⟹ ENSCAFP00000014403

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	31	32,511,502 - 32,652,572 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000063999 ⟹ ENSCAFP00000043879

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	31	32,511,502 - 32,646,621 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000067458 ⟹ ENSCAFP00000047873

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	31	32,511,502 - 32,651,996 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050841 ⟹ ENSCAFP00845039854

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	31	31,811,351 - 31,956,735 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050846 ⟹ ENSCAFP00845039858

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	31	31,811,351 - 31,951,254 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050873 ⟹ ENSCAFP00845039882

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	31	31,811,351 - 31,951,249 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050926 ⟹ ENSCAFP00845039923

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	31	31,811,365 - 31,960,042 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050986 ⟹ ENSCAFP00845039970

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	31	31,812,334 - 31,959,954 (+)	Ensembl

RefSeq Acc Id:

XM_038443495 ⟹ XP_038299423

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	31	31,812,898 - 31,959,979 (+)	NCBI

RefSeq Acc Id:

XM_038443496 ⟹ XP_038299424

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	31	31,866,483 - 31,959,979 (+)	NCBI

RefSeq Acc Id:

XM_038443497 ⟹ XP_038299425

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	31	31,867,957 - 31,959,979 (+)	NCBI

RefSeq Acc Id:

XM_038461700 ⟹ XP_038317628

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	31	31,572,154 - 31,719,378 (+)	NCBI

RefSeq Acc Id:

XM_038461701 ⟹ XP_038317629

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	31	31,626,121 - 31,719,378 (+)	NCBI

RefSeq Acc Id:

XM_038461702 ⟹ XP_038317630

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	31	31,627,593 - 31,719,378 (+)	NCBI

RefSeq Acc Id:

XM_038517907 ⟹ XP_038373835

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	31	31,682,502 - 31,829,001 (+)	NCBI

RefSeq Acc Id:

XM_038517908 ⟹ XP_038373836

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	31	31,736,010 - 31,829,001 (+)	NCBI

RefSeq Acc Id:

XM_038517909 ⟹ XP_038373837

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	31	31,737,484 - 31,829,001 (+)	NCBI

RefSeq Acc Id:

XM_038581475 ⟹ XP_038437403

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	31	32,186,102 - 32,332,696 (+)	NCBI

RefSeq Acc Id:

XM_038581476 ⟹ XP_038437404

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	31	32,239,595 - 32,332,696 (+)	NCBI

RefSeq Acc Id:

XM_038581477 ⟹ XP_038437405

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	31	32,241,069 - 32,332,696 (+)	NCBI

RefSeq Acc Id:

XM_038645858 ⟹ XP_038501786

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	31	31,695,751 - 31,842,602 (+)	NCBI

RefSeq Acc Id:

XM_038645859 ⟹ XP_038501787

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	31	31,749,288 - 31,842,602 (+)	NCBI

RefSeq Acc Id:

XM_038645860 ⟹ XP_038501788

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	31	31,750,762 - 31,842,602 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038299423	(Get FASTA)	NCBI Sequence Viewer
	XP_038299424	(Get FASTA)	NCBI Sequence Viewer
	XP_038299425	(Get FASTA)	NCBI Sequence Viewer
	XP_038317628	(Get FASTA)	NCBI Sequence Viewer
	XP_038317629	(Get FASTA)	NCBI Sequence Viewer
	XP_038317630	(Get FASTA)	NCBI Sequence Viewer
	XP_038373835	(Get FASTA)	NCBI Sequence Viewer
	XP_038373836	(Get FASTA)	NCBI Sequence Viewer
	XP_038373837	(Get FASTA)	NCBI Sequence Viewer
	XP_038437403	(Get FASTA)	NCBI Sequence Viewer
	XP_038437404	(Get FASTA)	NCBI Sequence Viewer
	XP_038437405	(Get FASTA)	NCBI Sequence Viewer
	XP_038501786	(Get FASTA)	NCBI Sequence Viewer
	XP_038501787	(Get FASTA)	NCBI Sequence Viewer
	XP_038501788	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000003635.4
	ENSCAFP00000014403.5
	ENSCAFP00000043879.1
	ENSCAFP00000047873.1
	ENSCAFP00000069961.1
	ENSCAFP00000071395.1
	ENSCAFP00030041205.1
	ENSCAFP00030041228.1
	ENSCAFP00030041236.1
	ENSCAFP00040034269.1
	ENSCAFP00040034328.1
	ENSCAFP00040034349.1
	ENSCAFP00845039854.1
	ENSCAFP00845039858.1
	ENSCAFP00845039882.1
	ENSCAFP00845039923
	ENSCAFP00845039923.1
	ENSCAFP00845039970
	ENSCAFP00845039970.1

Ensembl Acc Id:

ENSCAFP00000014403 ⟸ ENSCAFT00000015565

Ensembl Acc Id:

ENSCAFP00000043879 ⟸ ENSCAFT00000063999

Ensembl Acc Id:

ENSCAFP00000003635 ⟸ ENSCAFT00000003933

Ensembl Acc Id:

ENSCAFP00000047873 ⟸ ENSCAFT00000067458

RefSeq Acc Id:	XP_038373835 ⟸ XM_038517907
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038373836 ⟸ XM_038517908
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038373837 ⟸ XM_038517909
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038501786 ⟸ XM_038645858
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038501787 ⟸ XM_038645859
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038501788 ⟸ XM_038645860
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038299423 ⟸ XM_038443495
- Peptide Label:	isoform X1
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL), A0A8C0PFN4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038299424 ⟸ XM_038443496
- Peptide Label:	isoform X2
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL), A0A8I3Q182 (UniProtKB/TrEMBL), A0A8P0NBW5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038299425 ⟸ XM_038443497
- Peptide Label:	isoform X3
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038317628 ⟸ XM_038461700
- Peptide Label:	isoform X1
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL), A0A8C0PFN4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038317629 ⟸ XM_038461701
- Peptide Label:	isoform X2
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL), A0A8I3Q182 (UniProtKB/TrEMBL), A0A8P0NBW5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038317630 ⟸ XM_038461702
- Peptide Label:	isoform X3
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038437403 ⟸ XM_038581475
- Peptide Label:	isoform X1
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL), A0A8C0PFN4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038437404 ⟸ XM_038581476
- Peptide Label:	isoform X2
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL), A0A8I3Q182 (UniProtKB/TrEMBL), A0A8P0NBW5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038437405 ⟸ XM_038581477
- Peptide Label:	isoform X3
- UniProtKB:	A0A8P0TMM7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845039970 ⟸ ENSCAFT00845050986

Ensembl Acc Id:

ENSCAFP00845039882 ⟸ ENSCAFT00845050873

Ensembl Acc Id:

ENSCAFP00845039854 ⟸ ENSCAFT00845050841

Ensembl Acc Id:

ENSCAFP00845039923 ⟸ ENSCAFT00845050926

Ensembl Acc Id:

ENSCAFP00845039858 ⟸ ENSCAFT00845050846

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000009801	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030025500	UniProtKB/TrEMBL
	ENSCAFG00040021129	UniProtKB/TrEMBL
	ENSCAFG00845028759	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000003933.6	UniProtKB/TrEMBL
	ENSCAFT00000015565.5	UniProtKB/TrEMBL
	ENSCAFT00000063999.2	UniProtKB/TrEMBL
	ENSCAFT00000067458.2	UniProtKB/TrEMBL
	ENSCAFT00000094743.1	UniProtKB/TrEMBL
	ENSCAFT00000096141.1	UniProtKB/TrEMBL
	ENSCAFT00030047134.1	UniProtKB/TrEMBL
	ENSCAFT00030047158.1	UniProtKB/TrEMBL
	ENSCAFT00030047166.1	UniProtKB/TrEMBL
	ENSCAFT00040039280.1	UniProtKB/TrEMBL
	ENSCAFT00040039348.1	UniProtKB/TrEMBL
	ENSCAFT00040039371.1	UniProtKB/TrEMBL
	ENSCAFT00845050841.1	UniProtKB/TrEMBL
	ENSCAFT00845050846.1	UniProtKB/TrEMBL
	ENSCAFT00845050873.1	UniProtKB/TrEMBL
	ENSCAFT00845050926	ENTREZGENE
	ENSCAFT00845050926.1	UniProtKB/TrEMBL
	ENSCAFT00845050986	ENTREZGENE
	ENSCAFT00845050986.1	UniProtKB/TrEMBL
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	PKc_DYR1A/1B	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	Ser_Thr_dual-spec_kinase	UniProtKB/TrEMBL
NCBI Gene	DYRK1A	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN KINASE	UniProtKB/TrEMBL
	PTHR24058:SF121	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C0PFN4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0RTK5_CANLF	UniProtKB/TrEMBL
	A0A8C0TDY6_CANLF	UniProtKB/TrEMBL
	A0A8I3Q182	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3Q657_CANLF	UniProtKB/TrEMBL
	A0A8I3Q672_CANLF	UniProtKB/TrEMBL
	A0A8I3QHG3_CANLF	UniProtKB/TrEMBL
	A0A8I3QQK0_CANLF	UniProtKB/TrEMBL
	A0A8P0N5H9_CANLF	UniProtKB/TrEMBL
	A0A8P0NBW5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TMM7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TPS2_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:40155	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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