Sec63 Reference Search Result - Rat Genome Database

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RGD ID	Title	Citation	Abstract	PubMed	Pub Date
14402049	Mutations in SEC63 cause autosomal dominant polycystic liver disease.	Davila S, etal., Nat Genet. 2004 Jun;36(6):575-7. doi: 10.1038/ng1357. Epub 2004 May 9.	Mutations in PRKCSH, encoding the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum (ER), cause autosomal dominant polycystic liver disease. We found that mutations in SEC63, encoding a component of the protein tra ... (more) nslocation machinery in the ER, also cause this disease. These findings are suggestive of a role for cotranslational protein-processing pathways in maintaining epithelial luminal structure and implicate noncilial ER proteins in human polycystic disease.	15133510	2004-06-01