Enables phosphoprotein binding activity and protein kinase binding activity. Involved in several processes, including cAMP/PKA signal transduction; establishment of skin barrier; and protein export from nucleus. Acts upstream of or within several processes, including keratinocyte differentiation; ne
gative regulation of cell population proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin). [provided by Alliance of Genome Resources, Jul 2025]
Predicted to enable 3'-5'-DNA exonuclease activity; 3'-5'-RNA exonuclease activity; and magnesium ion binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Located in mitochondrion. Is expressed i
n several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human REXO2 (RNA exonuclease 2). [provided by Alliance of Genome Resources, Jul 2025]