Rnf4 Gene Search Result

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10 records found for search term Rnf4

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
737479	Rnf4	ring finger protein 4	This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocy ... (more) tic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]	5	34493594	34510789	Mouse	225	symbol , old_gene_name , PhenoGen	gene, protein-coding, REVIEWED [RefSeq]
1622861	A830049F12Rik	RIKEN cDNA A830049F12 gene	Is expressed in adrenal gland; amygdala; and telencephalon mantle layer. [provided by Alliance of Genome Resources, Jul 2025]	5	34492474	34494549	Mouse		old_gene_symbol	gene, protein-coding, MODEL [RefSeq]
737000	Rnf40	ring finger protein 40	Predicted to enable several functions, including enzyme binding activity; protein homodimerization activity; and syntaxin-1 binding activity. Predicted to be involved in positive regulation of macromolecule metabolic process and ubiquitin-dependent protein catabolic process. Predicted to be located ... (more) in nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and islets of Langerhans. Orthologous to human RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Jul 2025]	7	127187936	127202777	Mouse	120	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1551303	Rnf41	ring finger protein 41	Enables erythropoietin receptor binding activity and interleukin-3 receptor binding activity. Acts upstream of or within negative regulation of mitophagy; protein polyubiquitination; and regulation of hemopoiesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in ... (more) endoplasmic reticulum tubular network. Is expressed in several structures, including central nervous system; dorsal root ganglion; male reproductive system; and urinary system. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Jul 2025]	10	128247485	128277310	Mouse	109	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1332400	Rnf43	ring finger protein 43	Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in plasma membrane. Is exp ... (more) ressed in several structures, including alimentary system; forelimb epidermis; genitourinary system; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Jul 2025]	11	87553913	87626365	Mouse	214	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1316272	Rnf44	ring finger protein 44	Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; male reproductive system; and urinary system. Orthologous to human RNF4 ... (more) '>RNF44 (ring finger protein 44). [provided by Alliance of Genome Resources, Jul 2025]	13	54827212	54841889	Mouse	73	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1312439	Bfar	bifunctional apoptosis regulator	Predicted to enable caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiq ... (more) uitination. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in central nervous system; heart valve; reproductive system; and urinary system. Orthologous to human BFAR (bifunctional apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2025]	16	13489722	13521476	Mouse	87	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
732625	Birc2	baculoviral IAP repeat-containing 2	Enables ubiquitin-protein transferase activity. Involved in necroptotic process and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including negative regulation of necroptotic process; negative regulation of ripoptosome assembly involved ... (more) in necroptotic process; and regulation of intracellular signal transduction. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including central nervous system; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Jul 2025]	9	7818227	7837123	Mouse	417	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
733266	Birc3	baculoviral IAP repeat-containing 3	Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in necroptotic process; negative regulation of metabolic process; and negative regulation of necroptotic process. Acts upstream of or within cellular respo ... (more) nse to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus adenocarcinoma; extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Jul 2025]	9	7848698	7873199	Mouse	533	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1315378	Znrf1	zinc and ring finger 1	Enables ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytosol and endosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane ... (more) . Is expressed in several structures, including central nervous system; genitourinary system; and retina nuclear layer. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Apr 2025]	8	112262652	112352352	Mouse	123	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]