Predicted to enable heme binding activity. Acts upstream of or within several processes, including positive regulation of immune effector process; positive regulation of type II interferon-mediated signaling pathway; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to b
e active in extracellular space. Is expressed in brain; embryo; liver; liver left lobe; and liver right lobe. Orthologous to human HPX (hemopexin). [provided by Alliance of Genome Resources, Apr 2025]
Predicted to enable iron chaperone activity; iron ion binding activity; and transferrin receptor binding activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of bone resorption; and positive regulation of metabolic process. Acts upstream of or within iron ion
transport and response to bacterium. Located in clathrin-coated pit and cytoplasmic vesicle. Is expressed in several structures, including blood; brain; liver; placenta; and white fat. Used to study atransferrinemia. Human ortholog(s) of this gene implicated in anemia (multiple); atransferrinemia; gastrointestinal system disease; glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to human TF (transferrin). [provided by Alliance of Genome Resources, Apr 2025]