| 1343189 | NDP | norrin cystine knot growth factor NDP | This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 200 9] | X | 43948776 | 43973390 | Human | 316 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 6481394 | NDP-AS1 | NDP antisense RNA 1 | | X | 43949732 | 43971552 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 735393 | NME1 | NME/NM23 nucleoside diphosphate kinase 1 | This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuro blastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008] | 17 | 51153559 | 51162168 | Human | 356 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1642401 | NME1-NME2 | NME1-NME2 readthrough | This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010] | 17 | 51153559 | 51171744 | Human | 35 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1346564 | NME2 | NME/NM23 nucleoside diphosphate kinase 2 | Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturall y-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] | 17 | 51165536 | 51171744 | Human | 254 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733554 | NME3 | NME/NM23 nucleoside diphosphate kinase 3 | Enables nucleoside diphosphate kinase activity. Involved in DNA repair; mitochondrial fusion; and nucleoside triphosphate biosynthetic process. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 1770320 | 1771543 | Human | 148 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1318408 | NME4 | NME/NM23 nucleoside diphosphate kinase 4 | The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008] | 16 | 396729 | 400754 | Human | 150 | old_gene_name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1604057 | NME6 | NME/NM23 nucleoside diphosphate kinase 6 | Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 1045 3732]).[supplied by OMIM, Jul 2010] | 3 | 48287640 | 48301367 | Human | 113 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 733959 | NME7 | NME/NM23 family member 7 | This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in au tophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] | 1 | 169132531 | 169367797 | Human | 157 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1343010 | NME5 | NME/NM23 family member 5 | Enables 3'-5' exonuclease activity. Involved in spermatid development. Predicted to be located in 9+2 motile cilium. Predicted to be part of radial spoke. Predicted to be active in cilium. Implicated in primary ciliary dyskinesia. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 138115175 | 138139428 | Human | 148 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1351599 | CARD8 | caspase recruitment domain family member 8 | The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010] | 19 | 48203148 | 48255946 | Human | 112 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1601886 | CALCOCO2 | calcium binding and coiled-coil domain 2 | This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] | 17 | 48831035 | 48865245 | Human | 87 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1316988 | ENAH | ENAH actin regulator | This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016] | 1 | 225486829 | 225653878 | Human | 144 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731754 | GABBR2 | gamma-aminobutyric acid type B receptor subunit 2 | The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010] | 9 | 98288109 | 98708935 | Human | 1189 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352693 | SLC9A6 | solute carrier family 9 member A6 | This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Ch ristianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] | X | 135973837 | 136047269 | Human | 300 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
