Map3k5 Gene Search Result

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

Genes search result for Homo sapiens
(View Results for all Objects and Ontologies)

5 records found for search term Map3k5

Refine Term:

Assembly:

Chr

Sort By:

Export

RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1315043	MAP3K5	mitogen-activated protein kinase kinase kinase 5	Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn acti ... (more) vates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]	6	136557046	136793091	Human	434	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
14700846	MAP3K5-AS1	MAP3K5 antisense RNA 1	INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine	6	136629114	136648198	Human	3	symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
38665603	MAP3K5-AS2	MAP3K5 antisense RNA 2		6	136784047	136786054	Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
16571757	AL121933.2	novel transcript, antisense to MAP3K5					Human		name	gene, lncrna
1320807	TPD52L1	TPD52 like 1	This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5 ... (more) ;'>MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]	6	125153773	125264407	Human	173	description	gene, protein-coding, REVIEWED [RefSeq]