| 1307272 | Zeb2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); R-SMAD binding (ortholog); INVOLVED IN astrocyte activation; endothelial cell migration; endotheli al cell proliferation; ASSOCIATED WITH astrocytosis; gliosis; ASSOCIATED WITH Brain Hypoxia-Ischemia; Fetal Nutrition Disorders; Gliosis; FOUND IN chromatin (ortholog); nucleolus (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol | 3 | 49624028 | 49754323 | Rat | 311 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1316368 | ZEB2 | zinc finger E-box binding homeobox 2 | The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mow at-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010] | 2 | 144384081 | 144520119 | Human | 618 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316369 | Zeb2 | zinc finger E-box binding homeobox 2 | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and R-SMAD binding activity. Involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within s everal processes, including nervous system development; positive regulation of axonogenesis; and positive regulation of signal transduction. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Mowat-Wilson syndrome and T-cell adult acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 44873523 | 45007378 | Mouse | 361 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8823517 | Zeb2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); R-SMAD binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell proliferation in fore brain (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Brain Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); cerebellar disease (ortholog); FOUND IN chromatin (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | NW_004955440 | 10755658 | 10881044 | Chinchilla | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11778154 | ZEB2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); R-SMAD binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell proliferation in forebrain (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Brai n Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); cerebellar disease (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); nucleolus (inferred) | 2B | 15325094 | 15460908 | Bonobo | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12259595 | ZEB2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN astrocyte activation (ortholog); cell proliferation in forebrain (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Brain Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); cerebellar disease (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); nucleolus (inferred) | 19 | 46419812 | 46541888 | Dog | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12526418 | Zeb2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN astrocyte activation (ortholog); cell proliferation in forebrain (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Brain Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); cerebellar disease (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); nucleolus (inferred) | NW_004936469 | 32240730 | 32372413 | Squirrel | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18936511 | Zeb2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); R-SMAD binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell proliferation in fore brain (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Brain Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); cerebellar disease (ortholog); FOUND IN chromatin (ortholog); nucleolus (ortholog) | | | | Naked Mole-Rat | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625847563 | Zeb2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); R-SMAD binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell proliferation in fore brain (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Brain Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); cerebellar disease (ortholog); FOUND IN chromatin (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18543961 | ZEB2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN astrocyte activation (ortholog); cell proliferation in forebrain (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Brain Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); cerebellar disease (ortholog); FOUND IN chromatin (inferred); chromosome (inferred); nucleolus (inferred) | | | | Green Monkey | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231540 | zeb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13870704 | ZEB2 | zinc finger E-box binding homeobox 2 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); R-SMAD binding (ortholog); INVOLVED IN astrocyte activation (ortholog); cell proliferation in fore brain (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Brain Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); cerebellar disease (ortholog); FOUND IN chromatin (ortholog); nucleolus (ortholog) | | | | Pig | 90 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258127 | zeb2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234662 | zeb2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2800586 | ZEB2-AS1 | ZEB2 antisense RNA 1 | This gene produces a spliced long non-coding RNA which is a natural antisense transcript corresponding to the 5' UTR of zinc finger E-box binding homeobox 2 (ZEB2). It is thought that this transcript may be involved in the regulation of ZEB2 700;'>ZEB2 expression, and may play a role in the progression of bladder cancer. [provided by RefSeq, Aug 2015] | 2 | 144519614 | 144520899 | Human | 14 | symbol , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 9273023 | Zeb2-as1 | ZEB2 antisense RNA 1 | ASSOCIATED WITH congestive heart failure (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 49752502 | 49755379 | Rat | 13 | symbol , PhenoGen , name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 14995351 | METAP2P1 | METAP2 pseudogene 1 | | 2 | 145825536 | 145827842 | Human | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 16570138 | AC009951.5 | novel transcript, antisense to ZEB2 | | | | | Human | | name | gene, lncrna |
| 1619643 | Zeb2os | zinc finger E-box binding homeobox 2, opposite strand | Orthologous to human ZEB2-AS1 (ZEB2 antisense RNA 1). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 45001150 | 45004099 | Mouse | 13 | symbol , PhenoGen , description , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 5509856 | ZEB2P1 | zinc finger E-box binding homeobox 2 pseudogene 1 | | 4 | 16360491 | 16361827 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |