| 1349181 | XRCC2 | X-ray repair cross complementing 2 | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chines e hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008] | 7 | 152644776 | 152676141 | Human | 415 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557193 | Xrcc2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | Predicted to enable ATP binding activity and ATP-dependent DNA damage sensor activity. Predicted to contribute to four-way junction DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of apoptotic process; and response to X-ray. Pr edicted to be located in nucleoplasm. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Is expressed in embryo. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 25894812 | 25910795 | Mouse | 205 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564823 | Xrcc2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits four-way junction DNA binding (ortholog); INVOLVED IN centrosome cycle (ortholog); DNA damage response (ortholog); DNA repair (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH breast carcinoma (ortholog); Breas t Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (ortholog); Rad51B-Rad51C-Rad51D-XRCC2 complex (ortholog); replication fork (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 4 | 10157130 | 10237089 | Rat | 169 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8741032 | Xrcc2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits four-way junction DNA binding (ortholog); INVOLVED IN centrosome cycle (ortholog); DNA damage response (ortholog); DNA repair (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH breast carcinoma (ortholog); Breas t Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (ortholog); Rad51B-Rad51C-Rad51D-XRCC2 complex (ortholog); replication fork (ortholog) | NW_004955491 | 6579443 | 6629410 | Chinchilla | 52 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 11854431 | XRCC2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent DNA damage sensor activity (inferred); DNA binding (inferred); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH breast carcinoma (ortholog); Breast Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | 7 | 144229031 | 144256854 | Bonobo | 65 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 12297562 | XRCC2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent DNA damage sensor activity (inferred); DNA binding (inferred); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH breast carcinoma (ortholog); Breast Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | 16 | 16402821 | 16429095 | Dog | 65 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 12703967 | Xrcc2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent DNA damage sensor activity (inferred); DNA binding (inferred); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH breast carcinoma (ortholog); Breast Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | NW_004936527 | 7760609 | 7785360 | Squirrel | 65 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 13948325 | XRCC2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent DNA damage sensor activity (inferred); DNA binding (inferred); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH breast carcinoma (ortholog); Breast Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | | | | Pig | 65 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 14389768 | Xrcc2 | | | | | | Fly | | symbol | gene, null |
| 18397303 | XRCC2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent DNA damage sensor activity (inferred); DNA binding (inferred); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH breast carcinoma (ortholog); Breast Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | | | | Green Monkey | 65 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 18935205 | Xrcc2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits four-way junction DNA binding (ortholog); INVOLVED IN centrosome cycle (ortholog); DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOC IATED WITH breast carcinoma (ortholog); Breast Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | | | | Naked Mole-Rat | 59 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 155244998 | xrcc2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626131380 | Xrcc2 | X-ray repair cross complementing 2 | ENCODES a protein that exhibits four-way junction DNA binding (ortholog); INVOLVED IN centrosome cycle (ortholog); DNA damage response (ortholog); DNA repair (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH breast carcinoma (ortholog); Breas t Neoplasms (ortholog); colon cancer (ortholog); FOUND IN centrosome (ortholog); Rad51B-Rad51C-Rad51D-XRCC2 complex (ortholog); replication fork (ortholog) | | | | Black Rat | 44 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 155231565 | xrcc2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 407429906 | xrcc2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 407429971 | xrcc2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 407429983 | xrcc2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 407429990 | xrcc2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240447 | xrcc2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12434827 | LOC102153218 | DNA repair protein XRCC2-like | | 5 | 63291012 | 63292646 | Dog | | name | gene, pseudo, MODEL [RefSeq] |
| 1344706 | RAD51B | RAD51 paralog B | The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts w ith the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016] | 14 | 67819779 | 68683096 | Human | 183 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1557356 | Rad51b | RAD51 paralog B | Predicted to enable ATP-dependent activity, acting on DNA; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Acts upstream of or within blastocyst growth; positive regulation of cell population prolifera tion; and somite development. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in replication fork. Is expressed in cerebral cortex; cranial ganglion; dorsal root ganglion; neural retina; and ventral grey horn. Orthologous to human RAD51B (RAD51 paralog B). [provided by Alliance of Genome Resources, Apr 2025] | 12 | 79344032 | 79895034 | Mouse | 186 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560681 | Rad51b | RAD51 paralog B | ENCODES a protein that exhibits ATP-dependent activity, acting on DNA (ortholog); double-stranded DNA binding (ortholog); four-way junction DNA binding (ortholog); INVOLVED IN blastocyst growth (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic develop ment (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN Rad51B-Rad51C-Rad51D-XRCC2 complex (ortholog); replication fork (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; atrazine; bisphenol A | 6 | 103829390 | 104373923 | Rat | 164 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8959727 | Rad51b | RAD51 paralog B | ENCODES a protein that exhibits ATP-dependent activity, acting on DNA (ortholog); double-stranded DNA binding (ortholog); four-way junction DNA binding (ortholog); INVOLVED IN blastocyst growth (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic develop ment (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN Rad51B-Rad51C-Rad51D-XRCC2 complex (ortholog); replication fork (ortholog) | NW_004955466 | 1686472 | 2388146 | Chinchilla | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 11746696 | RAD51B | RAD51 paralog B | ENCODES a protein that exhibits four-way junction DNA binding (ortholog); INVOLVED IN blastocyst growth (ortholog); in utero embryonic development (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repa ir; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleus (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | 14 | 48399345 | 49314577 | Bonobo | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 12264952 | RAD51B | RAD51 paralog B | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent activity, acting on DNA (inferred); ATP-dependent DNA damage sensor activity (inferred); INVOLVED IN blastocyst growth (ortholog); in utero embryonic development (ortholog); positive regulation of cell population proliferation (or tholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleus (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | 8 | 41779435 | 42357362 | Dog | 49 | description | gene, protein-coding, MODEL [RefSeq] |
| 12576208 | Rad51b | RAD51 paralog B | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent activity, acting on DNA (inferred); ATP-dependent DNA damage sensor activity (inferred); INVOLVED IN blastocyst growth (ortholog); in utero embryonic development (ortholog); positive regulation of cell population proliferation (or tholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleus (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | NW_004936495 | 11185560 | 11762254 | Squirrel | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 13993290 | RAD51B | RAD51 paralog B | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent activity, acting on DNA (inferred); ATP-dependent DNA damage sensor activity (inferred); INVOLVED IN blastocyst growth (ortholog); in utero embryonic development (ortholog); positive regulation of cell population proliferation (or tholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleus (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 50 | description | gene, protein-coding, MODEL [RefSeq] |
| 18415176 | RAD51B | RAD51 paralog B | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent activity, acting on DNA (inferred); ATP-dependent DNA damage sensor activity (inferred); INVOLVED IN blastocyst growth (ortholog); in utero embryonic development (ortholog); positive regulation of cell population proliferation (or tholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleus (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | | | | Green Monkey | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 18908602 | Rad51b | RAD51 paralog B | ENCODES a protein that exhibits four-way junction DNA binding (ortholog); INVOLVED IN blastocyst growth (ortholog); in utero embryonic development (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repa ir; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleus (inferred); Rad51B-Rad51C-Rad51D-XRCC2 complex (inferred); replication fork (inferred) | | | | Naked Mole-Rat | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 626054794 | Rad51b | RAD51 paralog B | ENCODES a protein that exhibits ATP-dependent activity, acting on DNA (ortholog); double-stranded DNA binding (ortholog); four-way junction DNA binding (ortholog); INVOLVED IN blastocyst growth (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic develop ment (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN Rad51B-Rad51C-Rad51D-XRCC2 complex (ortholog); replication fork (ortholog) | | | | Black Rat | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 1315846 | RAD51D | RAD51 paralog D | The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other me mbers of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011] | 17 | 35092221 | 35119860 | Human | 449 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315847 | Rad51d | RAD51 paralog D | This gene belongs to the Rad51 gene family whose products play a major role in homologous recombination and DNA repair. The encoded protein interacts with other proteins of this family, including Rad51b, Rad51c and Xrcc2, and plays an essential role in both DNA repair and telomere maintenance. In humans, germline mutations in this gene may be associated with predisposition to ovarian cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] | 11 | 82762786 | 82781571 | Mouse | 184 | description | gene, protein-coding, REVIEWED [RefSeq] |