| 1319835 | TRIM8 | tripartite motif containing 8 | This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have be en observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016] | 10 | 102644479 | 102658319 | Human | 265 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1319836 | Trim8 | tripartite motif-containing 8 | Predicted to enable several functions, including mitogen-activated protein kinase kinase kinase binding activity; protein homodimerization activity; and transcription coactivator activity. Involved in host-mediated suppression of symbiont invasion; negative regulation of viral transcription; and sup pression of viral release by host. Acts upstream of or within positive regulation of protein localization to nucleus and stem cell population maintenance. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; female reproductive system; and urinary system. Orthologous to human TRIM8 (tripartite motif containing 8). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 46490087 | 46504894 | Mouse | 158 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1585223 | Trim8 | tripartite motif-containing 8 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding; identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN canonical NF-kappaB signal transduction (ortholog); host-mediated suppression of symbiont invasion (ortholog); innat e immune response (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Focal Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 1 | 255311039 | 255325937 | Rat | 119 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9018113 | Trim8 | tripartite motif containing 8 | ENCODES a protein that exhibits identical protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN canonical NF-kappaB signal transduction (ortholog); host-mediated suppression of symbiont invasion (ortho log); innate immune response (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Focal Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955485 | 7784625 | 7798131 | Chinchilla | 35 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12042484 | TRIM8 | tripartite motif containing 8 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN positive regulation of protein localization to nucleus (ortholog); stem cell population maintenance (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Foc al Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 10 | 99242187 | 99256342 | Bonobo | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12064349 | TRIM8 | tripartite motif containing 8 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN positive regulation of protein localization to nucleus (ortholog); stem cell population maintenance (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Foc al Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 28 | 15124310 | 15138660 | Dog | 42 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12524811 | Trim8 | tripartite motif containing 8 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN positive regulation of protein localization to nucleus (ortholog); stem cell population maintenance (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Foc al Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936600 | 3244888 | 3259042 | Squirrel | 42 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14018326 | TRIM8 | tripartite motif containing 8 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN positive regulation of protein localization to nucleus (ortholog); stem cell population maintenance (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Foc al Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 42 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18345700 | TRIM8 | tripartite motif containing 8 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN positive regulation of protein localization to nucleus (ortholog); stem cell population maintenance (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Foc al Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 44 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18928876 | Trim8 | tripartite motif containing 8 | ENCODES a protein that exhibits identical protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN canonical NF-kappaB signal transduction (ortholog); host-mediated suppression of symbiont invasion (ortho log); negative regulation of viral transcription (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Focal Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155244242 | trim8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625957072 | Trim8 | tripartite motif containing 8 | ENCODES a protein that exhibits identical protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN canonical NF-kappaB signal transduction (ortholog); host-mediated suppression of symbiont invasion (ortho log); innate immune response (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Focal Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 35 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155244243 | trim8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856222 | trim8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859008 | trim8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860964 | trim8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865311 | trim8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177814 | trim8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626186947 | trim8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16566624 | TRIM8-DT | TRIM8 divergent transcript | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, lncrna |
| 126848828 | TRIM8-DT | TRIM8 divergent transcript | | 10 | 102642792 | 102643189 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 18918385 | LOC101724579 | probable E3 ubiquitin-protein ligase TRIM8 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18906316 | LOC106009558 | probable E3 ubiquitin-protein ligase TRIM8 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1311352 | Trim80 | tripartite motif protein 80 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN immune system process (inferred); innate immune response (inferred); FOUND IN cytoplasm (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3-chloropropan e-1,2-diol | 10 | 101181797 | 101190122 | Rat | 18 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1615479 | Trim80 | tripartite motif-containing 80 | Orthologous to human TRIM80P (tripartite motif containing 80, pseudogene). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 115331371 | 115339094 | Mouse | 17 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12174727 | TRIM80 | tripartite motif containing 80 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN immune system process (inferred); innate immune response (inferred); FOUND IN cytoplasm (inferred) | 9 | 5401186 | 5407129 | Dog | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 10400655 | TRIM80P | tripartite motif containing 80, pseudogene | INTERACTS WITH sodium arsenite; (1->4)-beta-D-glucan (ortholog); 4,4'-sulfonyldiphenol (ortholog) | 17 | 75074306 | 75079549 | Human | 8 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1344917 | TRIM53AP | tripartite motif containing 53A, pseudogene | INTERACTS WITH valproic acid | 11 | 89993541 | 90002508 | Human | 1 | old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 2311723 | TRIM53BP | tripartite motif containing 53B, pseudogene | | 11 | 89841993 | 89851264 | Human | | old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |