| 1308039 | Tp53bp1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits histone H4K20me methyltransferase activity (ortholog); histone H4K20me2 reader activity (ortholog); histone reader activity (ortholog); INVOLVED IN cellular response to X-ray; DNA damage response (ortholog); double-strand break repair via classical nonhomologous end j oining (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nuclear body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; atrazine | 3 | 128620320 | 128724716 | Rat | 242 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1317577 | TP53BP1 | tumor protein p53 binding protein 1 | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling followi ng DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] | 15 | 43403061 | 43510640 | Human | 238 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9001392 | Tp53bp1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits histone H4K20me methyltransferase activity (ortholog); histone H4K20me2 reader activity (ortholog); histone reader activity (ortholog); INVOLVED IN cellular response to X-ray (ortholog); DNA damage response (ortholog); double-strand break repair via classical nonhomol ogous end joining (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nuclear body (ortholog) | NW_004955416 | 9962736 | 10035433 | Chinchilla | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12018501 | TP53BP1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits DNA binding (inferred); histone binding (inferred); histone H4K20me methyltransferase activity (inferred); INVOLVED IN cellular response to X-ray (ortholog); DNA damage response (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN site of double-strand break (ortholog) | 15 | 22364696 | 22472499 | Bonobo | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12324739 | TP53BP1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits DNA binding (inferred); histone H4K20me methyltransferase activity (inferred); histone H4K20me2 reader activity (inferred); INVOLVED IN cellular response to X-ray (ortholog); DNA damage response (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN site of double-strand break (ortholog) | 30 | 10263650 | 10362646 | Dog | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12597541 | Tp53bp1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits DNA binding (inferred); histone binding (inferred); histone H4K20me methyltransferase activity (inferred); INVOLVED IN cellular response to X-ray (ortholog); DNA damage response (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN site of double-strand break (ortholog) | NW_004936471 | 6589395 | 6668242 | Squirrel | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626055247 | Tp53bp1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits histone H4K20me methyltransferase activity (ortholog); histone H4K20me2 reader activity (ortholog); histone reader activity (ortholog); INVOLVED IN cellular response to X-ray (ortholog); DNA damage response (ortholog); double-strand break repair via classical nonhomol ogous end joining (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nuclear body (ortholog) | | | | Black Rat | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920639 | Tp53bp1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits histone H4K20me methyltransferase activity (ortholog); histone reader activity (ortholog); p53 binding (ortholog); INVOLVED IN cellular response to X-ray (ortholog); DNA damage response (ortholog); double-strand break repair via classical nonhomologous end joining (or tholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285417920 | tp53bp1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18503031 | TP53BP1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits DNA binding (inferred); histone binding (inferred); histone H4K20me methyltransferase activity (inferred); INVOLVED IN cellular response to X-ray (ortholog); DNA damage response (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN site of double-strand break (ortholog) | | | | Green Monkey | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13867798 | TP53BP1 | tumor protein p53 binding protein 1 | ENCODES a protein that exhibits DNA binding (inferred); histone H4K20me methyltransferase activity (inferred); histone H4K20me2 reader activity (inferred); INVOLVED IN cellular response to X-ray (ortholog); DNA damage response (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Breast Neoplasms (ortholog); Colonic Neoplasms (ortholog); glioblastoma (ortholog); FOUND IN site of double-strand break (ortholog) | | | | Pig | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083144 | tp53bp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083171 | tp53bp1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1317578 | Trp53bp1 | transformation related protein 53 binding protein 1 | Enables damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype swit ching. Acts upstream of or within DNA repair. Located in chromosome and nuclear body. Part of DNA repair complex. Is expressed in several structures, including ileum; liver; lung; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 121025316 | 121126830 | Mouse | 264 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |