| 1305847 | Spopl | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH 17beta-estr adiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 3 | 26478535 | 26552344 | Rat | 67 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1314125 | Spopl | speckle-type BTB/POZ protein-like | Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of proteolysis. Predicted to be part of C ul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 23382942 | 23462139 | Mouse | 76 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605812 | SPOPL | speckle type BTB/POZ protein like | Enables identical protein binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 138501770 | 138573547 | Human | 70 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8907676 | Spopl | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog) | NW_004955440 | 5594970 | 5612677 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11980489 | SPOPL | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nucleus (inferred) | 2B | 21280143 | 21351547 | Bonobo | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12357441 | SPOPL | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nucleus (inferred) | 19 | 41167511 | 41240741 | Dog | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12497508 | Spopl | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nucleus (inferred) | NW_004936469 | 37608044 | 37661337 | Squirrel | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18532869 | SPOPL | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog) | | | | Green Monkey | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13915889 | SPOPL | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nucleus (inferred) | | | | Pig | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912001 | Spopl | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248877 | spopl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 20867228 | SPOPL | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nucleus (inferred) | | | | Green Monkey | 7 | symbol | gene, protein-coding |
| 155239982 | spopl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249928 | spopl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38660427 | SPOPL-DT | SPOPL divergent transcript | | 2 | 138491063 | 138501695 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 38666082 | SPOPLP1 | SPOPL pseudogene 1 | | 4 | 69125214 | 69128072 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 38656547 | SPOPLP2 | SPOPL pseudogene 2 | | 4 | 68995339 | 68997711 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 38669489 | SPOPLP3 | SPOPL pseudogene 3 | | 4 | 68882301 | 68884447 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16558186 | AC021146.2 | speckle-type POZ protein-like (SPOPL) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16558810 | AC021146.7 | speckle-type POZ protein-like (SPOPL) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16559192 | AC111000.5 | speckle-type POZ protein-like (SPOPL) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1317451 | Tdpoz1 | TD and POZ domain containing 1 | Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. Is expressed in early conceptus; oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 93576640 | 93583590 | Mouse | 19 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |