| 1352693 | SLC9A6 | solute carrier family 9 member A6 | This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Ch ristianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] | X | 135973837 | 136047269 | Human | 300 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558403 | Slc9a6 | solute carrier family 9 (sodium/hydrogen exchanger), member 6 | Enables potassium:proton antiporter activity and sodium:proton antiporter activity. Involved in regulation of intracellular pH and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within several processes, including brain-derived neurotrophic factor receptor signaling pathway; dendritic spine development; and regulation of neurotrophin TRK receptor signaling pathway. Located in several cellular components, including axon; dendrite; and endosome. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Used to study Christianson syndrome. Human ortholog(s) of this gene implicated in Christianson syndrome. Orthologous to human SLC9A6 (solute carrier family 9 member A6). [provided by Alliance of Genome Resources, Jul 2025] | X | 55654921 | 55709590 | Mouse | 181 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1563582 | Slc9a6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); potassium:proton antiporter activity (ortholog); sodium:proton antiporter activity (ortholog); INVOLVED IN glial cell activation; regulation of synaptic vesicle lumen acidification; axon extension (ortholog); PARTICIPATES IN angio tensin II signaling pathway via AT2 receptor; ASSOCIATED WITH abnormal lysosome physiology; astrocytosis; axon degeneration; ASSOCIATED WITH astigmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN presynapse; axon terminus (ortholog); axonal spine (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-methoxyethanol | X | 139468045 | 139524111 | Rat | 162 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8855587 | Slc9a6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); potassium:proton antiporter activity (ortholog); sodium:proton antiporter activity (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ort holog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH astigmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN axon terminus (ortholog); axonal spine (ortholog); cytoplasmic vesicle (ortholog) | NW_004955489 | 9020719 | 9078375 | Chinchilla | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11969228 | SLC9A6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH asti gmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN early endosome membrane (ortholog); endoplasmic reticulum membrane (ortholog); late endosome membrane (ortholog) | X | 125099378 | 125171161 | Bonobo | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12280422 | SLC9A6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH asti gmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN early endosome membrane (ortholog); endoplasmic reticulum membrane (ortholog); late endosome membrane (ortholog) | X | 106408789 | 106465504 | Dog | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12734492 | Slc9a6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH asti gmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN early endosome membrane (ortholog); endoplasmic reticulum membrane (ortholog); late endosome membrane (ortholog) | NW_004936513 | 11158609 | 11215477 | Squirrel | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902111 | Slc9a6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH asti gmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN axon terminus (ortholog); axonal spine (ortholog); cytoplasmic vesicle (ortholog) | | | | Naked Mole-Rat | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13991164 | SLC9A6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH asti gmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN early endosome membrane (ortholog); endoplasmic reticulum membrane (ortholog); late endosome membrane (ortholog) | | | | Pig | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625957627 | Slc9a6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); potassium:proton antiporter activity (ortholog); sodium:proton antiporter activity (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ort holog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH astigmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN axon terminus (ortholog); axonal spine (ortholog); cytoplasmic vesicle (ortholog) | | | | Black Rat | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259977 | slc9a6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18675238 | SLC9A6 | solute carrier family 9 member A6 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH asti gmatism (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2A (ortholog); Christianson syndrome (ortholog); FOUND IN early endosome membrane (ortholog); endoplasmic reticulum membrane (ortholog); late endosome membrane (ortholog) | | | | Green Monkey | 72 | symbol | gene, protein-coding |
| 405865651 | slc9a6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863102 | slc9a6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856454 | slc9a6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856349 | slc9a6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 628374415 | slc9a6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 151664749 | Slc9a6 em1Moro | solute carrier family 9 member A6;CRISPR/Cas9 induced mutant1, Moro | ASSOCIATED WITH abnormal lysosome physiology; astrocytosis; axon degeneration | | | | Rat | 16 | symbol , description | gene, allele |
| 1350922 | SLC9A7 | solute carrier family 9 member A7 | This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. Th is protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] | X | 46599251 | 46759118 | Human | 143 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |