| 621399 | Skil | SKI-like proto-oncogene | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of axonogenesis; response to cytokine; spermatogenesis; PARTICIPATES IN transformin g growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis; ureteral obstruction; Arsenic Poisoning (ortholog); FOUND IN acrosomal vesicle; cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; bisphenol A | 2 | 114175534 | 114203663 | Rat | 190 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1314830 | SKIL | SKI like proto-oncogene | The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor co mplex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] | 3 | 170357715 | 170396849 | Human | 201 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1314831 | Skil | SKI-like proto-oncogene | This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain cancer cells, where it may have bo th tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012] | 3 | 31149259 | 31176741 | Mouse | 217 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8952419 | Skil | SKI like proto-oncogene | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (or tholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | NW_004955420 | 530531 | 554308 | Chinchilla | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11881361 | SKIL | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog) | 3 | 167372104 | 167411287 | Bonobo | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12425642 | SKIL | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); PML body (ortholog) | 34 | 34871770 | 34898681 | Dog | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12542248 | Skil | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); PML body (ortholog) | NW_004936593 | 2109414 | 2132871 | Squirrel | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18386871 | SKIL | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog) | | | | Green Monkey | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14148873 | SKIL | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); PML body (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626121444 | Skil | SKI like proto-oncogene | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (or tholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915127 | Skil | SKI like proto-oncogene | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (or tholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254686 | skil | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155254687 | skil.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249830 | skil.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2311688 | Skil_v1 | SKI-like proto-oncogene, variant 1 | | | | | Rat | | symbol | gene, splice |
| 2311690 | Skil_v2 | SKI-like proto-oncogene, variant 2 | | | | | Rat | | symbol , old_gene_symbol | gene, splice |