| 708497 | Sipa1l1 | signal-induced proliferation-associated 1 like 1 | ENCODES a protein that exhibits actin filament binding; protein kinase binding; protein-containing complex binding; INVOLVED IN actin cytoskeleton organization; activation of GTPase activity; postsynaptic actin cytoskeleton organization; ASSOCIATED WITH diastolic heart failure (ortholog); juvenile r heumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN dendritic spine; glutamatergic synapse; neuronal cell body; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,4-methylenedioxymethamphetamine | 6 | 107570569 | 107849613 | Rat | 175 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733053 | SIPA1L1 | signal induced proliferation associated 1 like 1 | Predicted to enable GTPase activator activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; ephrin receptor signaling pathway; and regulation of postsynapse organization. Located in actin cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 71320476 | 71741209 | Human | 160 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1332242 | Sipa1l1 | signal-induced proliferation-associated 1 like 1 | Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway and regulation of axonogenesis. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 82216138 | 82498560 | Mouse | 187 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8985349 | Sipa1l1 | signal induced proliferation associated 1 like 1 | ENCODES a protein that exhibits actin filament binding (ortholog); ephrin receptor binding (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of GTPase activity (ortholog); ephrin receptor signaling pathway (ortholog); ASSOCIATED WITH di astolic heart failure (ortholog); juvenile rheumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN actin cytoskeleton (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog) | NW_004955523 | 3545807 | 3908329 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11736750 | SIPA1L1 | signal induced proliferation associated 1 like 1 | ENCODES a protein that exhibits actin filament binding (ortholog); protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of GTPase activity (ortholog); postsynaptic actin cytoskeleton organization (ortholo g); ASSOCIATED WITH diastolic heart failure (ortholog); juvenile rheumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | 14 | 51909444 | 52328719 | Bonobo | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12269246 | SIPA1L1 | signal induced proliferation associated 1 like 1 | ENCODES a protein that exhibits actin filament binding (ortholog); protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN activation of GTPase activity (ortholog); postsynaptic actin cytoskeleton organization (ortholog); regulation of dendrite morphogenesis (or tholog); ASSOCIATED WITH diastolic heart failure (ortholog); juvenile rheumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | 8 | 44916309 | 45260197 | Dog | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12651863 | Sipa1l1 | signal induced proliferation associated 1 like 1 | ENCODES a protein that exhibits actin filament binding (ortholog); protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of GTPase activity (ortholog); postsynaptic actin cytoskeleton organization (ortholo g); ASSOCIATED WITH diastolic heart failure (ortholog); juvenile rheumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | NW_004936488 | 819503 | 1175043 | Squirrel | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18745718 | SIPA1L1 | signal induced proliferation associated 1 like 1 | ENCODES a protein that exhibits actin filament binding (ortholog); protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of GTPase activity (ortholog); postsynaptic actin cytoskeleton organization (ortholo g); ASSOCIATED WITH diastolic heart failure (ortholog); juvenile rheumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13911262 | SIPA1L1 | signal induced proliferation associated 1 like 1 | ENCODES a protein that exhibits actin filament binding (ortholog); protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN activation of GTPase activity (ortholog); postsynaptic actin cytoskeleton organization (ortholog); regulation of dendrite morphogenesis (or tholog); ASSOCIATED WITH diastolic heart failure (ortholog); juvenile rheumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | | | | Pig | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626040807 | Sipa1l1 | signal induced proliferation associated 1 like 1 | ENCODES a protein that exhibits actin filament binding (ortholog); ephrin receptor binding (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of GTPase activity (ortholog); ephrin receptor signaling pathway (ortholog); ASSOCIATED WITH di astolic heart failure (ortholog); juvenile rheumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN actin cytoskeleton (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908498 | Sipa1l1 | signal induced proliferation associated 1 like 1 | ENCODES a protein that exhibits actin filament binding (ortholog); ephrin receptor binding (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of GTPase activity (ortholog); ephrin receptor signaling pathway (ortholog); ASSOCIATED WITH di astolic heart failure (ortholog); juvenile rheumatoid arthritis (ortholog); Weight Gain (ortholog); FOUND IN actin cytoskeleton (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245198 | sipa1l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155245197 | sipa1l1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254685 | sipa1l1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38622002 | SIPA1L1-AS1 | SIPA1L1 antisense RNA 1 | | 14 | 71292724 | 71321848 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16570814 | AC004974.1 | novel transcript, antisense to SIPA1L1 | | | | | Human | | name | gene, lncrna |
| 16570728 | LOC124903342 | uncharacterized LOC124903342 | | 14 | 71734925 | 71739720 | Human | | old_gene_name | gene, ncrna, MODEL [RefSeq] |