| 1311018 | Robo3 | roundabout guidance receptor 3 | INVOLVED IN positive regulation of axon guidance; axon guidance (ortholog); axon midline choice point recognition (ortholog); ASSOCIATED WITH Brain Injuries; autistic disorder (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3 ,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 8 | 45322323 | 45340466 | Rat | 88 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1322248 | ROBO3 | roundabout guidance receptor 3 | This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for R OBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. [provided by RefSeq, May 2019] | 11 | 124865432 | 124881471 | Human | 162 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322249 | Robo3 | roundabout guidance receptor 3 | Involved in axon midline choice point recognition and commissural neuron axon guidance. Acts upstream of or within neuron migration. Located in axon. Is expressed in several structures, including central nervous system; cranial nerve; future brain; head mesenchyme; and sensory organ. Orthologous to human ROBO3 (roundabout guidance receptor 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 37327341 | 37344730 | Mouse | 116 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8752547 | Robo3 | roundabout guidance receptor 3 | INVOLVED IN axon guidance (ortholog); axon midline choice point recognition (ortholog); commissural neuron axon guidance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (ortholog) | NW_004955412 | 25937624 | 25953458 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12018822 | ROBO3 | roundabout guidance receptor 3 | INVOLVED IN axon guidance (ortholog); neuron migration (ortholog); positive regulation of axon guidance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (inferred); membrane (inferred) | 11 | 119692232 | 119708309 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12172107 | ROBO3 | roundabout guidance receptor 3 | INVOLVED IN axon guidance (ortholog); neuron migration (ortholog); positive regulation of axon guidance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (inferred); membrane (inferred) | 5 | 9563353 | 9579111 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12604914 | Robo3 | roundabout guidance receptor 3 | INVOLVED IN axon guidance (ortholog); neuron migration (ortholog); positive regulation of axon guidance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (inferred); membrane (inferred) | NW_004936743 | 1305108 | 1321819 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18577704 | ROBO3 | roundabout guidance receptor 3 | INVOLVED IN axon guidance (ortholog); neuron migration (ortholog); positive regulation of axon guidance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (inferred); membrane (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 150657678 | ROBO3 | roundabout guidance receptor 3 | INVOLVED IN axon midline choice point recognition (inferred); cell differentiation (inferred); chemotaxis (inferred); FOUND IN axon (inferred); membrane (inferred) | | | | Dog | 14 | symbol | gene, protein-coding |
| 155257393 | robo3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14075250 | ROBO3 | roundabout guidance receptor 3 | INVOLVED IN axon guidance (ortholog); neuron migration (ortholog); positive regulation of axon guidance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (inferred); membrane (inferred) | | | | Pig | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902322 | Robo3 | roundabout guidance receptor 3 | INVOLVED IN axon guidance (ortholog); commissural neuron axon guidance (ortholog); neuron migration (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (inferred); membrane (inferred) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625850452 | Robo3 | roundabout guidance receptor 3 | INVOLVED IN axon guidance (ortholog); axon midline choice point recognition (ortholog); commissural neuron axon guidance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); conjugate gaze palsy (ortholog); FOUND IN axon (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14387179 | robo3 | | | | | | Fly | | symbol | gene, null |
| 405857062 | robo3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857772 | robo3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858777 | robo3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858523 | robo3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626188586 | robo3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232056 | robo3.S | | | | | | African Clawed Frog | | symbol | gene, null |
