| 621144 | Rab8a | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits protein kinase binding; protein tyrosine kinase binding; G protein activity (ortholog); INVOLVED IN axonogenesis; cellular response to insulin stimulus; neurotransmitter receptor transport to postsynaptic membrane; PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN cytoplasmic vesicle; dendrite; glutamatergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil | 16 | 17688049 | 17709412 | Rat | 232 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1354512 | RAB8A | RAB8A, member RAS oncogene family | The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008] | 19 | 16111889 | 16134234 | Human | 209 | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1621605 | Rab8a | RAB8A, member RAS oncogene family | Predicted to enable several functions, including enzyme binding activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in cilium assembly and protein localization to cilium. Located in several cellular components, including ciliary base; ciliary membrane; and cytop lasmic vesicle. Is expressed in brain; liver; neural retina; and small intestine. Orthologous to human RAB8A (RAB8A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 72915044 | 72935210 | Mouse | 268 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8892522 | Rab8a | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); cilium assembly (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); ciliary base (ortholog) | NW_004955524 | 1403811 | 1416005 | Chinchilla | 85 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12042726 | RAB8A | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits protein kinase binding (ortholog); protein tyrosine kinase binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); endocytic recycling (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter medi ated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN ciliary base (ortholog); ciliary membrane (ortholog); dendrite (ortholog) | 19 | 15598029 | 15619988 | Bonobo | 85 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12203917 | RAB8A | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN endocytic recycling; axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucos e transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN exocytic vesicle; centrosome (ortholog); ciliary basal body (ortholog) | 20 | 46334601 | 46351907 | Dog | 75 | symbol , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12636638 | Rab8a | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits protein kinase binding (ortholog); protein tyrosine kinase binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); endocytic recycling (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter medi ated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN dendrite (ortholog); exocytic vesicle (ortholog); glutamatergic synapse (ortholog) | NW_004936596 | 4385788 | 4403393 | Squirrel | 86 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626071319 | Rab8a | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); cilium assembly (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); ciliary base (ortholog) | | | | Black Rat | 85 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 155242933 | rab8a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13920032 | RAB8A | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits protein kinase binding (ortholog); protein tyrosine kinase binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); neurotransmitter receptor transport, endosome to postsynaptic membrane (ortholog); PARTICIPATES IN ins ulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN dendrite (ortholog); exocytic vesicle (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 96 | symbol , name | gene, protein-coding, VALIDATED [RefSeq] |
| 18726553 | RAB8A | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits protein kinase binding (ortholog); protein tyrosine kinase binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); endocytic recycling (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter medi ated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN ciliary base (ortholog); ciliary membrane (ortholog); dendrite (ortholog) | | | | Green Monkey | 85 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18922599 | Rab8a | RAB8A, member RAS oncogene family | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); myosin V binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); cilium assembly (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter med iated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); ciliary base (ortholog) | | | | Naked Mole-Rat | 94 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 155246085 | rab8a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242932 | rab8a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 597830049 | HSH2D-AS1 | HSH2D and RAB8A antisense RNA 1 | | 19 | 16121839 | 16139915 | Human | | name | gene, ncrna, VALIDATED [RefSeq] |
| 16565141 | AC008894.2 | novel transcript, antisense RAB8A | | | | | Human | | name | gene, lncrna |
