| 3250 | Pak1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; INVOLVED IN cellular response to insulin stimulus; cerebellum development; establishment of cell polarity; PARTICIPATES IN adenosine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury; brain ischemia; Neointima; FOUND IN axon; dendrite; intercalated disc; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; 1-octadec-9-enoylglycero-3-phosphate | 1 | 161522399 | 161637623 | Rat | 339 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736234 | Pak1 | p21 (RAC1) activated kinase 1 | Enables protein serine/threonine kinase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including nervous system development; neurotransmitter secretion; and observational learning. Locat ed in several cellular components, including dendrite; growth cone; and nucleus. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 97437748 | 97561588 | Mouse | 356 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346880 | PAK1 | p21 (RAC1) activated kinase 1 | This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This speci fic family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020] | 11 | 77322017 | 77530009 | Human | 378 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8977620 | Pak1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits collagen binding (ortholog); gamma-tubulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); branching morphogenesis of an epithelial tube (ortholog); PARTICIPATES IN aden osine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN actin filament (ortholog); axon (ortholog); cell-cell junction (ortholog) | NW_004955414 | 14365325 | 14447470 | Chinchilla | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11915044 | PAK1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); cell migration (ortholog); PARTICIPATES IN adenosine signaling pathway ; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); GABA-ergic synapse (ortholog) | 11 | 72372577 | 72524817 | Bonobo | 172 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12271253 | PAK1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); cell migration (ortholog); PARTICIPATES IN adenosine signaling pathway ; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH bisphenol A | 21 | 21341530 | 21409535 | Dog | 177 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12650357 | Pak1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); cell migration (ortholog); PARTICIPATES IN adenosine signaling pathway ; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); GABA-ergic synapse (ortholog) | NW_004936498 | 6001126 | 6135663 | Squirrel | 168 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13977533 | PAK1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits collagen binding (ortholog); identical protein binding (ortholog); protein kinase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); branching morphogenesis of an epithelial tube (ortholog); PARTICIPATES IN ad enosine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); cytoplasm (ortholog) | | | | Pig | 189 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18667733 | PAK1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); cell migration (ortholog); PARTICIPATES IN adenosine signaling pathway ; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); GABA-ergic synapse (ortholog) | | | | Green Monkey | 170 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929966 | Pak1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits collagen binding (ortholog); gamma-tubulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); branching morphogenesis of an epithelial tube (ortholog); PARTICIPATES IN aden osine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN actin filament (ortholog); axon (ortholog); cell-cell junction (ortholog) | | | | Naked Mole-Rat | 166 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259569 | pak1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625908716 | Pak1 | p21 (RAC1) activated kinase 1 | ENCODES a protein that exhibits collagen binding (ortholog); gamma-tubulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); branching morphogenesis of an epithelial tube (ortholog); PARTICIPATES IN aden osine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN actin filament (ortholog); axon (ortholog); cell-cell junction (ortholog) | | | | Black Rat | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405857324 | pak1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861723 | pak1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862483 | pak1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862700 | pak1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626171344 | pak1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626181245 | pak1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252680 | pak1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7546946 | Pak1-ps1 | p21 (RAC1) activated kinase 1, pseudogene 1 | | 1 | 251733428 | 251736511 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 68610 | Pkn1 | protein kinase N1 | Enables protein kinase activity. Acts upstream of or within several processes, including negative regulation of B cell proliferation; regulation of macromolecule metabolic process; and spleen development. Located in cytoplasmic vesicle. Is expressed in several structures, including brown fat; genito urinary system; gut; nervous system; and vascular system. Orthologous to human PKN1 (protein kinase N1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 84393162 | 84425819 | Mouse | 204 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1352784 | PKN1 | protein kinase N1 | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent pro tein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] | 19 | 14433306 | 14471859 | Human | 155 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1353310 | PAK1IP1 | PAK1 interacting protein 1 | Predicted to enable protein kinase inhibitor activity. Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 10690865 | 10709782 | Human | 115 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1558380 | Pak1ip1 | PAK1 interacting protein 1 | Predicted to enable protein kinase inhibitor activity. Acts upstream of or within cell population proliferation and roof of mouth development. Located in nucleolus. Is expressed in several structures, including brain; chondrocranium; face; heart; and liver. Orthologous to human PAK1 ght:700;'>PAK1IP1 (PAK1 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 41154486 | 41166509 | Mouse | 138 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1565353 | Pak1ip1 | PAK1 interacting protein 1 | INVOLVED IN cell population proliferation (ortholog); regulation of signal transduction by p53 class mediator (ortholog); ribosomal large subunit biogenesis (ortholog); FOUND IN nucleolus (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 17 | 23947978 | 23959055 | Rat | 110 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8934841 | Pak1ip1 | PAK1 interacting protein 1 | INVOLVED IN cell population proliferation (ortholog); regulation of signal transduction by p53 class mediator (ortholog); ribosomal large subunit biogenesis (ortholog); FOUND IN nucleolus (ortholog) | NW_004955465 | 3635004 | 3644638 | Chinchilla | 10 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11867165 | PAK1IP1 | PAK1 interacting protein 1 | INVOLVED IN cell population proliferation (ortholog); roof of mouth development (ortholog); FOUND IN nucleolus (inferred) | 6 | 10535863 | 10550978 | Bonobo | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12413651 | PAK1IP1 | PAK1 interacting protein 1 | INVOLVED IN cell population proliferation (ortholog); roof of mouth development (ortholog); FOUND IN nucleolus (inferred) | 35 | 10436179 | 10446078 | Dog | 16 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12509347 | Pak1ip1 | PAK1 interacting protein 1 | INVOLVED IN cell population proliferation (ortholog); roof of mouth development (ortholog); FOUND IN nucleolus (inferred) | NW_004936534 | 2251512 | 2260260 | Squirrel | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14247615 | PAK1IP1 | PAK1 interacting protein 1 | ENCODES a protein that exhibits kinase activity (inferred); INVOLVED IN cell population proliferation (ortholog); roof of mouth development (ortholog); FOUND IN nucleolus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 18 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18474268 | PAK1IP1 | PAK1 interacting protein 1 | INVOLVED IN cell population proliferation (ortholog); roof of mouth development (ortholog); FOUND IN nucleolus (inferred) | | | | Green Monkey | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18913503 | Pak1ip1 | PAK1 interacting protein 1 | ENCODES a protein that exhibits kinase activity (inferred); INVOLVED IN cell population proliferation (ortholog); regulation of signal transduction by p53 class mediator (ortholog); ribosomal large subunit biogenesis (ortholog); FOUND IN nucleolus (inferred) | | | | Naked Mole-Rat | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626158027 | Pak1ip1 | PAK1 interacting protein 1 | INVOLVED IN cell population proliferation (ortholog); regulation of signal transduction by p53 class mediator (ortholog); ribosomal large subunit biogenesis (ortholog); FOUND IN nucleolus (ortholog) | | | | Black Rat | 10 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 16573202 | AC118281.1 | Cysteine-rich PAK1 inhibitor | INTERACTS WITH perfluorohexanesulfonic acid; perfluorononanoic acid; perfluorooctanoic acid | | | | Human | 3 | old_gene_name , name | gene, protein-coding |
| 9273430 | Cripak | cysteine-rich PAK1 inhibitor | | | | | Rat | | name | gene, protein-coding |
| 16565017 | AP003680.1 | novel transcript, antisense to PAK1 | | | | | Human | | name | gene, lncrna |
| 11704665 | LOC100986180 | putative protein CRIPAK | | 4 | 1539411 | 1541808 | Bonobo | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12795567 | Gm46735 | predicted gene, 46735 | | 2 | 36081958 | 36083741 | Mouse | | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |
| 155260220 | pak1ip1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405857170 | pak1ip1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860884 | pak1ip1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863982 | pak1ip1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865263 | pak1ip1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626184362 | pak1ip1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258218 | pak1ip1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1317048 | PAK4 | p21 (RAC1) activated kinase 4 | PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 19 | 39125786 | 39182816 | Human | 153 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1347334 | RHOU | ras homolog family member U | This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskelet al organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011] | 1 | 228644647 | 228746669 | Human | 164 | description | gene, protein-coding, REVIEWED [RefSeq] |