| 620999 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding; identical protein binding; protein kinase C binding; INVOLVED IN development of secondary female sexual characteristics; neurogenesis; neuron cellular homeostasis; ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm; dendrite; extracell ular space; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 128222333 | 128542127 | Rat | 142 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732316 | NELL2 | neural EGFL like 2 | The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one iso form appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009] | 12 | 44508275 | 44921848 | Human | 141 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 732317 | Nell2 | NEL-like 2 | Enables identical protein binding activity. Involved in commissural neuron axon guidance and fertilization. Located in extracellular region. Is expressed in several structures, including alimentary system; autopod; central nervous system; limb mesenchyme; and sensory organ. Orthologous to human ... (more) n style='font-weight:700;'>NELL2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 95117321 | 95426677 | Mouse | 152 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8862144 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits calcium ion binding (ortholog); heparin binding (ortholog); identical protein binding (ortholog); INVOLVED IN commissural neuron axon guidance (ortholog); development of secondary female sexual characteristics (ortholog); fertilization (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); extracellular region (ortholog) | NW_004955500 | 3669893 | 4049765 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11963866 | NELL2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN dendrite (ortholog); extracellular space (ortholog); perikaryon (ortholog) | 12 | 43820215 | 44226249 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12209092 | NELL2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); extracellular space (ortholog) | 27 | 9300001 | 9680974 | Dog | 31 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12581997 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN dendrite (ortholog); extracellular space (ortholog); perikaryon (ortholog) | NW_004936512 | 2862823 | 3225350 | Squirrel | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626053600 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits calcium ion binding (ortholog); heparin binding (ortholog); identical protein binding (ortholog); INVOLVED IN commissural neuron axon guidance (ortholog); development of secondary female sexual characteristics (ortholog); fertilization (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); extracellular region (ortholog) | | | | Black Rat | 28 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155249957 | nell2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18924276 | Nell2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN commissural neuron axon guidance (ortholog); development of secondary female sexual characteristics (ortholog); fertilization (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN dendrite (ortholog); extracellular region (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 30 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14037010 | NELL2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); extracellular space (ortholog) | | | | Pig | 31 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18707435 | NELL2 | neural EGFL like 2 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN development of secondary female sexual characteristics (ortholog); neurogenesis (ortholog); neuron cellular homeostasis (ortholog); ASSOCIATED WITH lung adenocarcinoma (ortholog); FOUND IN dendrite (ortholog); extracellular space (ortholog); perikaryon (ortholog) | | | | Green Monkey | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155233246 | nell2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256859 | nell2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 20867172 | C4orf48 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (inferred); RNA binding (inferred); transferrin receptor binding (inferred); INVOLVED IN 3'-UTR-mediated mRNA stabilization (inferred); spermatogenesis (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred); perinuclea r region of cytoplasm (inferred) | | | | Green Monkey | 8 | name | gene, protein-coding |
| 1560394 | Nicol1 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); transferrin receptor binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); spermatogenesis (ortholog); FOUND IN extracellular space (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH 2,3,7,8- tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A | 14 | 80992697 | 80994213 | Rat | 44 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1617958 | Nicol1 | NELL2 interacting cell ontogeny regulator 1 | Enables mRNA 3'-UTR binding activity and transferrin receptor binding activity. Involved in 3'-UTR-mediated mRNA stabilization and spermatogenesis. Located in extracellular space and perinuclear region of cytoplasm. Orthologous to human NICOL1 (NELL2 interacting cell ontogeny regulator 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 34140863 | 34142353 | Mouse | 55 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2301122 | NICOL1 | NELL2 interacting cell ontogeny regulator 1 | Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 2036554 | 2043964 | Human | 51 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8997851 | Nicol1 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); transferrin receptor binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); spermatogenesis (ortholog); FOUND IN extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004955514 | 1200732 | 1201730 | Chinchilla | 7 | name | gene, protein-coding, MODEL [RefSeq] |
| 11954933 | NICOL1 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); transferrin receptor binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); spermatogenesis (ortholog); FOUND IN extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | 4 | 2184128 | 2186148 | Bonobo | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12332734 | NICOL1 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (inferred); RNA binding (inferred); transferrin receptor binding (inferred); INVOLVED IN 3'-UTR-mediated mRNA stabilization (inferred); spermatogenesis (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred); perinuclea r region of cytoplasm (inferred) | 3 | 62119568 | 62121981 | Dog | 11 | name | gene, protein-coding, MODEL [RefSeq] |
| 14169879 | NICOL1 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (inferred); RNA binding (inferred); transferrin receptor binding (inferred); INVOLVED IN 3'-UTR-mediated mRNA stabilization (inferred); spermatogenesis (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred); perinuclea r region of cytoplasm (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 12 | name | gene, protein-coding, MODEL [RefSeq] |
| 625840625 | Nicol1 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); transferrin receptor binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); spermatogenesis (ortholog); FOUND IN extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Black Rat | 7 | name | gene, protein-coding, MODEL [RefSeq] |
| 18617412 | NICOL1 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); transferrin receptor binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); spermatogenesis (ortholog); FOUND IN extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Green Monkey | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18905078 | Nicol1 | NELL2 interacting cell ontogeny regulator 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); transferrin receptor binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); spermatogenesis (ortholog); FOUND IN extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 9 | name | gene, protein-coding, MODEL [RefSeq] |