| 727966 | Kat7 | lysine acetyltransferase 7 | ENCODES a protein that exhibits DNA replication origin binding (ortholog); histone acetyltransferase activity (ortholog); histone H3K14 acetyltransferase activity (ortholog); INVOLVED IN DNA replication-dependent chromatin disassembly (ortholog); internal peptidyl-lysine acetylation (ortholog); natu ral killer cell differentiation (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH androgen insensitivity syndrome (ortholog); breast cancer (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN chromosome (ortholog); histone acetyltransferase complex (ortholog); histone H3-K14 acetyltransferase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 10 | 80718335 | 80752387 | Rat | 228 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737003 | KAT7 | lysine acetyltransferase 7 | The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016] | 17 | 49788681 | 49835026 | Human | 180 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1332547 | Kat7 | K(lysine) acetyltransferase 7 | Enables histone H3K14 acetyltransferase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of erythrocyte differentiation; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Part of histone H3-K14 acetyltransferase compl ex. Is expressed in central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 95162683 | 95201030 | Mouse | 233 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 13983905 | KAT7 | lysine acetyltransferase 7 | ENCODES a protein that exhibits histone H4K16 acetyltransferase activity (ortholog); INVOLVED IN internal peptidyl-lysine acetylation (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH androgen insensitivity syndrome (ortholog); breast cancer (ortholog); hereditary breast ovar ian cancer syndrome (ortholog); FOUND IN nucleolus (ortholog) | | | | Pig | 89 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18911190 | Kat7 | lysine acetyltransferase 7 | ENCODES a protein that exhibits DNA replication origin binding (ortholog); histone H3K23 acetyltransferase activity (ortholog); histone H3K4 acetyltransferase activity (ortholog); INVOLVED IN DNA replication-dependent chromatin disassembly (ortholog); internal peptidyl-lysine acetylation (ortholog); natural killer cell differentiation (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH androgen insensitivity syndrome (ortholog); breast cancer (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN chromosome (ortholog); histone acetyltransferase complex (ortholog); nucleolus (ortholog) | | | | Naked Mole-Rat | 81 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 27374585 | KAT7P1 | KAT7 pseudogene 1 | | X | 95973134 | 95974314 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1350406 | ORC1 | origin recognition complex subunit 1 | The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] | 1 | 52372829 | 52409503 | Human | 332 | description | gene, protein-coding, REVIEWED [RefSeq] |