| 1308974 | Melk | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits calcium ion binding (ortholog); non-membrane spanning protein tyrosine kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN apoptotic process (ortholog); cell population proliferation (ortholog); intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (ortholog); cytoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 5 | 63336151 | 63396254 | Rat | 194 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1319059 | MELK | maternal embryonic leucine zipper kinase | Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 36572895 | 36677682 | Human | 195 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319060 | Melk | maternal embryonic leucine zipper kinase | Enables protein serine/threonine kinase activity. Involved in neural precursor cell proliferation and positive regulation of apoptotic process. Acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 44300876 | 44364301 | Mouse | 203 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9067469 | Melk | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits calcium ion binding (ortholog); non-membrane spanning protein tyrosine kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN apoptotic process (ortholog); cell population proliferation (ortholog); intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (ortholog); cytoplasm (ortholog); plasma membrane (ortholog) | NW_004955419 | 29718291 | 29815163 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11764824 | MELK | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); kinase activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog ); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); plasma membrane (inferred) | 9 | 36419974 | 36522584 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12333122 | MELK | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); kinase activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog ); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); plasma membrane (inferred) | 11 | 52970699 | 53067169 | Dog | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12559687 | Melk | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); kinase activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog ); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); plasma membrane (inferred) | NW_004936524 | 4479639 | 4544561 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625861999 | Melk | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits calcium ion binding (ortholog); non-membrane spanning protein tyrosine kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN apoptotic process (ortholog); cell population proliferation (ortholog); intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (ortholog); cytoplasm (ortholog); plasma membrane (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14193016 | MELK | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); kinase activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog ); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); plasma membrane (inferred) | | | | Pig | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18737444 | MELK | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); kinase activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog ); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); plasma membrane (inferred) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917621 | Melk | maternal embryonic leucine zipper kinase | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); kinase activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog ); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239246 | melk | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155239245 | melk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864820 | melk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626185741 | melk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864662 | melk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859444 | melk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861679 | melk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 736943 | Kcnh3 | potassium voltage-gated channel, subfamily H (eag-related), member 3 | The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. An increase in cognitive function was observed when this gene was knocked out, while deletion of the gene resulted in hippocampal hyperexcitability and epilepsy. [provided by RefSeq, Sep 2015] | 15 | 99122396 | 99140699 | Mouse | 104 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |