| 1306565 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits MAP kinase kinase kinase activity; ATP binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; endothelial cell apoptotic process; PARTICIPATES IN c-Jun N-terminal kinase s MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH Brain Hypoxia-Ischemia; Carotid Artery Injuries; cerebral infarction; FOUND IN external side of plasma membrane; cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; 4-vinylcyclohexene dioxide | 1 | 16505387 | 16723899 | Rat | 420 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315043 | MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn acti vates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] | 6 | 136557046 | 136793091 | Human | 434 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315044 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of JNK cascade; and positive regulation of myoblast differentiation. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intrinsic apoptotic signaling pathway in response to oxidative stress; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 19809847 | 20018496 | Mouse | 442 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8895901 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); JUN kinase kinase kinase activity (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular response to amino acid starvation (ortholog); cellular response to hydrogen peroxide (ortholog); PA RTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Arterial Injury (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); external side of plasma membrane (ortholog) | NW_004955439 | 162499 | 376919 | Chinchilla | 131 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11859568 | MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); cellular response to reactive nitrogen species (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Arterial Injury (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN external side of plasma membrane (ortholog) | 6 | 134316841 | 134582843 | Bonobo | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12077495 | MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); cellular response to reactive nitrogen species (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Arterial Injury (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH bisphenol A | 1 | 29107813 | 29306437 | Dog | 145 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12496493 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); cellular response to reactive nitrogen species (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Arterial Injury (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN external side of plasma membrane (ortholog) | NW_004936560 | 3988696 | 4197953 | Squirrel | 140 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14239150 | MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); cellular response to reactive nitrogen species (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Arterial Injury (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH copper(II) sulfate; deoxynivalenol; hydrogen peroxide | | | | Pig | 150 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18762228 | MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); cellular response to reactive nitrogen species (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Arterial Injury (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN external side of plasma membrane (ortholog) | | | | Green Monkey | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907430 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits identical protein binding (ortholog); JUN kinase kinase kinase activity (ortholog); magnesium ion binding (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular response to amino acid starvation (ortholog); cellular response to hydrogen peroxide (ort holog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Arterial Injury (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); external side of plasma membrane (ortholog) | | | | Naked Mole-Rat | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236906 | map3k5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625907554 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); JUN kinase kinase kinase activity (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular response to amino acid starvation (ortholog); cellular response to hydrogen peroxide (ortholog); PA RTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Arterial Injury (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); external side of plasma membrane (ortholog) | | | | Black Rat | 131 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14700846 | MAP3K5-AS1 | MAP3K5 antisense RNA 1 | INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine | 6 | 136629114 | 136648198 | Human | 3 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 38665603 | MAP3K5-AS2 | MAP3K5 antisense RNA 2 | | 6 | 136784047 | 136786054 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16571757 | AL121933.2 | novel transcript, antisense to MAP3K5 | | | | | Human | | name | gene, lncrna |
| 1320807 | TPD52L1 | TPD52 like 1 | This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5 ;'>MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016] | 6 | 125153773 | 125264407 | Human | 173 | description | gene, protein-coding, REVIEWED [RefSeq] |