| 1308676 | Hsd3b1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | ENCODES a protein that exhibits 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity; NAD binding; steroid binding; INVOLVED IN adrenal gland development; C21-steroid hormone biosynthetic process; cellular response to antibiotic; PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alph a-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH hyperprolactinemia; hypertension; hypogonadism; FOUND IN mitochondrial crista; endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH (+)-taxifolin; (-)-citrinin; (E)-thiamethoxam | 2 | 188858574 | 188864694 | Rat | 591 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1318589 | Hsd3b1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Enables steroid Delta-isomerase activity. Involved in androgen biosynthetic process. Located in mitochondrion. Is expressed in several structures, including endocrine gland; genitourinary system; liver; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 98749672 | 98767110 | Mouse | 597 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1347893 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016] | 1 | 119507203 | 119515058 | Human | 592 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 14234219 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | ENCODES a protein that exhibits 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity (ortholog); NAD binding (ortholog); steroid binding (ortholog); INVOLVED IN adrenal gland development (ortholog); androgen biosynthetic process (ortholog); C21-steroid hormone biosynthetic process (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); hyperprolactinemia (ortholog); hypertension (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); mitochondrial crista (ortholog); INTERACTS WITH bisphenol A; cadmium atom; Cloprostenol | | | | Pig | 105 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155243846 | hsd3b1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933504 | hsd3b1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933598 | hsd3b1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934343 | hsd3b1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935176 | hsd3b1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155243845 | hsd3b1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257185 | hsd3b1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933599 | hsd3b1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934561 | hsd3b1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934573 | hsd3b1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935175 | hsd3b1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 67377 | Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | ENCODES a protein that exhibits 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity; steroid Delta-isomerase activity; INVOLVED IN androgen biosynthetic process; C21-steroid hormone biosynthetic process; hippocampus development; PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alph a-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH hyperprolactinemia; hypertension; Adrenal Hyperplasia 2 (ortholog); FOUND IN endoplasmic reticulum (ortholog); INTERACTS WITH (R,R,R)-alpha-tocopherol; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 188784614 | 188812535 | Rat | 204 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12233818 | HSD3B2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | ENCODES a protein that exhibits 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity (ortholog); steroid Delta-isomerase activity (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); C21-steroid hormone biosynthetic process (ortholog); hippocampus development (ortholog); PARTICIP ATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH Adrenal Hyperplasia 2 (ortholog); Alzheimer's disease (ortholog); congenital adrenal hyperplasia (ortholog); FOUND IN endoplasmic reticulum (ortholog) | 17 | 56552945 | 56561062 | Dog | 59 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18907071 | LOC101707488 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | ENCODES a protein that exhibits isomerase activity (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (inferred); INVOLVED IN steroid biosynthetic process (inferred); FOUND IN endoplasmic reticulum membrane (inferred) ; mitochondrial membrane (inferred) | | | | Naked Mole-Rat | 6 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8810044 | LOC102017156 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | | NW_004955435 | 22646282 | 22653042 | Chinchilla | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18401252 | LOC103224100 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 pseudogene | | | | | Green Monkey | | old_gene_symbol | gene, pseudo, MODEL [RefSeq] |
| 11961889 | LOC100983009 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | ENCODES a protein that exhibits 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (inferred); INVOLVED IN androgen biosynthetic process (inferred); progeste rone biosynthetic process (inferred); steroid biosynthetic process (inferred); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); mitochondrial inner membrane (inferred) | 1 | 83039118 | 83046953 | Bonobo | 12 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18372480 | LOC103224104 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | ENCODES a protein that exhibits 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (inferred); INVOLVED IN progesterone biosynthetic process (inferred); ster oid biosynthetic process (inferred); FOUND IN endoplasmic reticulum (inferred); mitochondrial inner membrane (inferred); mitochondrial intermembrane space (inferred) | | | | Green Monkey | 9 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1615188 | Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | Predicted to enable 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity and steroid Delta-isomerase activity. Predicted to be involved in C21-steroid hormone biosynthetic process; androgen biosynthetic process; and negative regulation of iron ion transport. Predicted to be located in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 98618423 | 98631859 | Mouse | 48 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615187 | Hsd3b3 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 | Predicted to enable 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity and steroid Delta-isomerase activity. Predicted to be involved in C21-steroid hormone biosynthetic process; androgen biosynthetic process; and negative regulation of iron ion transport. Located in mitochondrial inner mem brane. Is expressed in adrenal gland; embryo; liver; testis; and testis medullary region. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 98648792 | 98672465 | Mouse | 93 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615186 | Hsd3b4 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 | Predicted to enable 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity; steroid Delta-isomerase activity; and steroid binding activity. Involved in response to stilbenoid. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; eye; genitour inary system; heart; and nervous system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 98406387 | 98417895 | Mouse | 63 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1553473 | Hsd3b5 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 | Predicted to enable 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity; steroid Delta-isomerase activity; and steroid binding activity. Involved in response to stilbenoid. Located in mitochondrial inner membrane. Is expressed in several structures, including adrenal gland; genitourinary sys tem; gut; liver and biliary system; and spleen. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 98525952 | 98552850 | Mouse | 101 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615185 | Hsd3b6 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 | Predicted to enable 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity and steroid Delta-isomerase activity. Predicted to be involved in C21-steroid hormone biosynthetic process; androgen biosynthetic process; and negative regulation of iron ion transport. Predicted to be located in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 98712820 | 98721759 | Mouse | 71 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2307760 | Hsd3b8 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 8 | Predicted to enable 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity; steroid Delta-isomerase activity; and steroid binding activity. Predicted to be involved in progesterone metabolic process; regulation of steroid biosynthetic process; and steroid biosynthetic process. Predicted to be l ocated in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Is expressed in several structures, including alimentary system; eye; heart; integumental system; and nervous system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 98459858 | 98471366 | Mouse | | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2307758 | Hsd3b9 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9 | Predicted to enable 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity; steroid Delta-isomerase activity; and steroid binding activity. Predicted to be involved in progesterone metabolic process; regulation of steroid biosynthetic process; and steroid biosynthetic process. Predicted to be l ocated in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; eye; heart; integumental system; and nervous system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 98352991 | 98364833 | Mouse | 22 | description | gene, protein-coding, VALIDATED [RefSeq] |