| 70958 | Gria3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity; amyloid-beta binding; glutamate-gated calcium ion channel activity; INVOLVED IN cellular response to glycine; long-term synaptic potentiation; regulation of receptor recycling; PARTICIPATES IN glutamate signaling pathway; long term de pression; ASSOCIATED WITH heroin dependence; amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN AMPA glutamate receptor complex; asymmetric synapse; dendrite; INTERACTS WITH (+)-pilocarpine; 1-nitropropane; 17beta-estradiol | X | 125103975 | 125369690 | Rat | 321 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 737336 | GRIA3 | glutamate ionotropic receptor AMPA type subunit 3 | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The c lassification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008] | X | 123184278 | 123490915 | Human | 409 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737337 | Gria3 | glutamate receptor, ionotropic, AMPA3 (alpha 3) | This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenot ypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] | X | 40489351 | 40767478 | Mouse | 324 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8799325 | Gria3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity (ortholog); amyloid-beta binding (ortholog); glutamate-gated calcium ion channel activity (ortholog); INVOLVED IN cellular response to glycine (ortholog); long-term synaptic potentiation (ortholog); protein heterotetramerization (ortho log); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); Developmental Disabilities (ortholog); FOUND IN AMPA glutamate receptor complex (ortholog); asymmetric synapse (ortholog); dendrite (ortholog) | NW_004955473 | 11283642 | 11574836 | Chinchilla | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11994621 | GRIA3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity (ortholog); amyloid-beta binding (ortholog); glutamate-gated calcium ion channel activity (ortholog); INVOLVED IN cellular response to glycine (ortholog); long-term synaptic potentiation (ortholog); regulation of receptor recycling (or tholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); Developmental Disabilities (ortholog); FOUND IN AMPA glutamate receptor complex (ortholog); asymmetric synapse (ortholog); dendrite (ortholog) | X | 112380229 | 112687740 | Bonobo | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12215651 | GRIA3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity (ortholog); amyloid-beta binding (ortholog); glutamate-gated calcium ion channel activity (ortholog); INVOLVED IN cellular response to glycine (ortholog); long-term synaptic potentiation (ortholog); regulation of receptor recycling (or tholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); Developmental Disabilities (ortholog); FOUND IN asymmetric synapse (ortholog); dendrite (ortholog); dendritic shaft (ortholog) | X | 94729828 | 95006244 | Dog | 86 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12718179 | Gria3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity (ortholog); amyloid-beta binding (ortholog); glutamate-gated calcium ion channel activity (ortholog); INVOLVED IN cellular response to glycine (ortholog); long-term synaptic potentiation (ortholog); regulation of receptor recycling (or tholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); Developmental Disabilities (ortholog); FOUND IN asymmetric synapse (ortholog); dendrite (ortholog); dendritic shaft (ortholog) | NW_004936479 | 7050018 | 7323047 | Squirrel | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18781296 | GRIA3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity (ortholog); amyloid-beta binding (ortholog); glutamate-gated calcium ion channel activity (ortholog); INVOLVED IN cellular response to glycine (ortholog); long-term synaptic potentiation (ortholog); regulation of receptor recycling (or tholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); Developmental Disabilities (ortholog); FOUND IN asymmetric synapse (ortholog); dendrite (ortholog); dendritic shaft (ortholog) | | | | Green Monkey | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625862166 | Gria3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity (ortholog); amyloid-beta binding (ortholog); glutamate-gated calcium ion channel activity (ortholog); INVOLVED IN cellular response to glycine (ortholog); long-term synaptic potentiation (ortholog); protein heterotetramerization (ortho log); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); Developmental Disabilities (ortholog); FOUND IN AMPA glutamate receptor complex (ortholog); asymmetric synapse (ortholog); dendrite (ortholog) | | | | Black Rat | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13962323 | GRIA3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity (ortholog); amyloid-beta binding (ortholog); glutamate-gated calcium ion channel activity (ortholog); INVOLVED IN cellular response to glycine (ortholog); long-term synaptic potentiation (ortholog); regulation of receptor recycling (or tholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); Developmental Disabilities (ortholog); FOUND IN asymmetric synapse (ortholog); dendrite (ortholog); dendritic shaft (ortholog) | | | | Pig | 86 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254383 | gria3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18927530 | Gria3 | glutamate ionotropic receptor AMPA type subunit 3 | ENCODES a protein that exhibits AMPA glutamate receptor activity (ortholog); amyloid-beta binding (ortholog); glutamate-gated calcium ion channel activity (ortholog); INVOLVED IN cellular response to glycine (ortholog); long-term synaptic potentiation (ortholog); protein heterotetramerization (ortho log); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); developmental and epileptic encephalopathy (ortholog); Developmental Disabilities (ortholog); FOUND IN asymmetric synapse (ortholog); dendrite (ortholog); dendritic shaft (ortholog) | | | | Naked Mole-Rat | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254384 | gria3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251172 | gria3.S | | | | | | African Clawed Frog | | symbol | gene, null |