| 621255 | Ago2 | argonaute RISC catalytic component 2 | ENCODES a protein that exhibits Hsp70 protein binding; Hsp90 protein binding; RISC complex binding; INVOLVED IN cellular response to calcium ion; negative regulation of amyloid precursor protein biosynthetic process; positive regulation of post-transcriptional gene silencing by RNA; PARTICIPATES IN microRNA pathway; ASSOCIATED WITH morphine dependence; withdrawal disorder; alcohol dependence (ortholog); FOUND IN chromatoid body; cytoplasm; cytoplasmic stress granule; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 106907209 | 106994124 | Rat | 352 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732767 | AGO2 | argonaute RISC catalytic component 2 | This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript va riants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] | 8 | 140520156 | 140642313 | Human | 412 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732768 | Ago2 | argonaute RISC catalytic subunit 2 | Enables RNA endonuclease activity; mRNA binding activity; and miRNA binding activity. Involved in positive regulation of mRNA catabolic process and pre-miRNA processing. Acts upstream of or within miRNA metabolic process; post-embryonic development; and regulation of gene expression. Located in seve ral cellular components, including P-body; cytosol; and dendrite. Part of RISC complex and RISC-loading complex. Is expressed in several structures, including central nervous system; early embryo; lung; sensory organ; and tooth. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Orthologous to human AGO2 (argonaute RISC catalytic component 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 72967693 | 73056777 | Mouse | 406 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 11780716 | AGO2 | argonaute RISC catalytic component 2 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); Hsp90 protein binding (ortholog); RISC complex binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); gene expression (ortholog); miRNA metabolic process (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED W ITH alcohol dependence (ortholog); Cocaine-Related Disorders (ortholog); genetic disease (ortholog); FOUND IN chromatoid body (ortholog); cytoplasm (ortholog); cytoplasmic stress granule (ortholog) | 8 | 137192037 | 137308059 | Bonobo | 183 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12319222 | AGO2 | argonaute RISC catalytic component 2 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); Hsp90 protein binding (ortholog); RISC complex binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); gene expression (ortholog); miRNA metabolic process (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED W ITH alcohol dependence (ortholog); Cocaine-Related Disorders (ortholog); genetic disease (ortholog); FOUND IN chromatoid body (ortholog); cytoplasm (ortholog); cytoplasmic stress granule (ortholog); INTERACTS WITH masitinib | 13 | 35169243 | 35230252 | Dog | 184 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14138598 | AGO2 | argonaute RISC catalytic component 2 | ENCODES a protein that exhibits Hsp70 protein binding (ortholog); Hsp90 protein binding (ortholog); RISC complex binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); gene expression (ortholog); miRNA metabolic process (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED W ITH alcohol dependence (ortholog); Cocaine-Related Disorders (ortholog); genetic disease (ortholog); FOUND IN chromatoid body (ortholog); cytoplasm (ortholog); cytoplasmic stress granule (ortholog); INTERACTS WITH 3,3',5,5'-tetrabromobisphenol A; bisphenol A; Tetrachlorobisphenol A | | | | Pig | 190 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |