| 1306973 | Btn2a2 | butyrophilin, subfamily 2, member A2 | INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of cytokine production (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); FOUND IN cell surface (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrac hlorodibenzodioxine | 17 | 42048842 | 42060650 | Rat | 57 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315891 | BTN2A2 | butyrophilin subfamily 2 member A2 | Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] | 6 | 26383108 | 26394874 | Human | 58 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1618951 | Btn2a2 | butyrophilin, subfamily 2, member A2 | Predicted to enable signaling receptor binding activity. Involved in negative regulation of activated T cell proliferation and negative regulation of cytokine production. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of signal transducti on; and positive regulation of regulatory T cell differentiation. Located in cell surface. Orthologous to several human genes including BTN2A2 (butyrophilin subfamily 2 member A2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 23661219 | 23673028 | Mouse | 64 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 13882356 | BTN2A2 | butyrophilin subfamily 2 member A2 | INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of cytokine production (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); FOUND IN cell surface (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254105 | btn2a2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18701231 | BTN2A2 | butyrophilin subfamily 2 member A2 | ENCODES a protein that exhibits signaling receptor binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of cytokine production (ortholog); negative regulati on of ERK1 and ERK2 cascade (ortholog); FOUND IN cell surface (ortholog) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257094 | btn2a2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 11915597 | LOC100975566 | butyrophilin subfamily 2 member A2 | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of G1/S transition of mitotic cell cycle (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); membrane (inferred) | 6 | 26215215 | 26227261 | Bonobo | 16 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8961290 | LOC102013416 | butyrophilin subfamily 2 member A2 | | NW_004955483 | 413795 | 498359 | Chinchilla | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12074674 | LOC100855640 | butyrophilin subfamily 2 member A2 | INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of G1/S transition of mitotic cell cycle (ortholog); FOUND IN cell surface (inferred); membrane (inferred) | 35 | 24251221 | 24265040 | Dog | 16 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |