| 2213 | Bmp4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits growth factor activity; identical protein binding; BMP receptor binding (ortholog); INVOLVED IN anatomical structure regression; cardiac muscle hypertrophy in response to stress; cellular response to BMP stimulus; PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glypican signaling pathway; basal cell carcinoma pathway; ASSOCIATED WITH Anorectal Malformations; Barrett's esophagus; Brain Hypoxia-Ischemia; FOUND IN extracellular space; vesicle; extracellular region (ortholog); INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane | 15 | 22098191 | 22113145 | Rat | 798 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10244 | Bmp4 | bone morphogenetic protein 4 | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016] | 14 | 46620982 | 46628126 | Mouse | 1168 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 730832 | BMP4 | bone morphogenetic protein 4 | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016] | 14 | 53949736 | 53956891 | Human | 962 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9045788 | Bmp4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits BMP receptor binding (ortholog); chemoattractant activity (ortholog); co-receptor binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anatomical structure regression (ortholog); angiogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glypican signaling pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); vesicle (ortholog) | NW_004955409 | 9432835 | 9439680 | Chinchilla | 377 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11899236 | BMP4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anatomical structure regression (ortholog); angiogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins s ignaling pathway; glypican signaling pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog) | 14 | 34542132 | 34549286 | Bonobo | 406 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12319071 | BMP4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anatomical structure regression (ortholog); angiogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins s ignaling pathway; glypican signaling pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog); INTERACTS WITH bisphenol A | 8 | 29997563 | 30254307 | Dog | 392 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12587279 | Bmp4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anatomical structure regression (ortholog); angiogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins s ignaling pathway; glypican signaling pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog) | NW_004936697 | 1054237 | 1061468 | Squirrel | 392 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18728925 | BMP4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anatomical structure regression (ortholog); angiogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins s ignaling pathway; glypican signaling pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog) | | | | Green Monkey | 404 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14239951 | BMP4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anatomical structure regression (ortholog); angiogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins s ignaling pathway; glypican signaling pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog); INTERACTS WITH ammonia | | | | Pig | 396 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625847555 | Bmp4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits BMP receptor binding (ortholog); chemoattractant activity (ortholog); co-receptor binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anatomical structure regression (ortholog); angiogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glypican signaling pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); vesicle (ortholog) | | | | Black Rat | 377 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257616 | bmp4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18911817 | Bmp4 | bone morphogenetic protein 4 | ENCODES a protein that exhibits BMP receptor binding (ortholog); chemoattractant activity (ortholog); co-receptor binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anatomical structure regression (ortholog); angiogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glypican signaling pathway; ASSOCIATED WITH ACTH-secreting pituitary adenoma (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog) | | | | Naked Mole-Rat | 395 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245977 | bmp4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250278 | bmp4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7242164 | Bmp4-ps | bone morphogenetic 4, pseudogene | | X | 89877828 | 89878666 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 16572248 | AL138479.2 | novel transcript, antisense to BMP4 | | | | | Human | | name | gene, lncrna |
| 8693267 | Rubie | RNA upstream of Bmp4 expressed in inner ear | This gene represents a non-coding RNA. It is located upstream of the Bmp4 gene (GeneID:12159), and is involved in regulating Bmp4 expression in the inner ear. The gene mutation results in vestibular malformation in mice. [pr ovided by RefSeq, Mar 2012] | 14 | 46805788 | 46813308 | Mouse | 9 | name , description | gene, ncrna, REVIEWED [RefSeq] |
| 1604514 | BMPER | BMP binding endothelial regulator | This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutati ons in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011] | 7 | 33904915 | 34156427 | Human | 278 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735776 | NOG | noggin | The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficien tly than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008] | 17 | 56593699 | 56595611 | Human | 500 | description | gene, protein-coding, REVIEWED [RefSeq] |
