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Strain Registration

Strain: SS.LEW-(D17Chm131-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)/Ayd

Symbol: SS.LEW-(D17Chm131-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)/Ayd
Strain: SS.LEW-(D17Chm131-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)
Substrain: Ayd
RGD ID: 8657348
Citation ID: RRID:RGD_8657348
Ontology ID: RS:0003777
Also Known As: CC(i); SS.LEW-(D17Chm31-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)/Ayd; C2S.M17/C17S.L11/C18S.L3; congenic combination (i); SS.LEW-(D17Chm31-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)/Ayd; SS.LEW-(D17Chm131-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)/Ayd
Type: congenic
Available Source: Not Available
Origination: Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada
Description: A triple congenic strain derived from the progenitor strain SS.LEW-(D17Chm31-D17Chm93)/Ayd, SS.MNS-(D2Rat155-D2Chm161)/Ayd and SS.LEW-(D18Chm41-D18Rat92)/Ayd
Last Known Status: Unknown





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. Crespo K, etal., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics SS.LEW-(D17Chm31-D17Chm93)/Ayd (C17S.L11) contains Bp369, SS.MNS-(D2Rat155-D2Chm161)/Ayd (C2S.M17) contains Bp363 and Bp364 and SS.LEW-(D18Chm41-D18Rat92)/Ayd (C18S.L3) contains Bp348 8657131
strain_life_disease expected to further decrease blood pressure 8657131
strain_life_disease impaired left ventricular relaxation, left ventricular hypertrophy, myocardial performance was improved thus improving diastolic function 8657131

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-11 SS.LEW-(D17Chm131-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)/Ayd    SS.LEW-(D17Chm31-D17Chm93),MNS-(D2Rat155-D2Chm161),LEW-(D18Chm41-D18Rat92)/Ayd    Symbol and/or name change 68913 APPROVED