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Strain Registration

Strain: DA.PVG.1AV1-(D9Wox24-D9Rat44)/Kini

Symbol: DA.PVG.1AV1-(D9Wox24-D9Rat44)/Kini
Strain: DA.PVG.1AV1-(D9Wox24-D9Rat44)
Substrain: Kini
RGD ID: 8552351
Citation ID: RRID:RGD_8552351
Ontology ID: RS:0003750
Also Known As: DA.PVG.1AV1-(D9Wox24-D9Rat44)/Kini; DA.BN-Eae4-R25; NBRP Rat No: 0703
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
Description: Inbred Dark Agouti (DA) rats were originally obtained from Hannover, Germany and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Briefly, in each backcross generation, rats for further breeding were selected on the basis of genotyping of 8 microsatellite markers in the congenic region, from marker D9Wox24 to D9Rat20. The genetic background of rats was also screened with 100 markers. After the complete removal of the donor genome outside the congenic fragment, two heterozygous rats were intercrossed to produce the homozygous strains DA.BN-Eae4(N7F1). Subsequently, interval-specific recombinants were bred from an F2 breeding. R25 recombinant was established in 2003.
Coat Color: agouti
Last Known Status: Cryopreserved Sperm
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr895,346,479 - 5,346,648RGD_MAPPER_PIPELINE
mRatBN7.291,024,537 - 5,109,995RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.092,880,977 - 10,869,489RGD_MAPPER_PIPELINERnor6.0
Rnor_5.092,813,697 - 9,858,600RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.492,948,882 - 2,949,051RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D9Wox24)
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,024,537 - 1,024,636 (-)MAPPER
Rnor_6.0910,869,391 - 10,869,489NCBI
Rnor_5.099,858,502 - 9,858,600UniSTS
Celera97,483,005 - 7,483,103UniSTS
Cytogenetic Map9q11UniSTS

Flank 2 / 1 (D9Rat44)
Rat AssemblyChrPosition (strand)Source
GRCr895,346,479 - 5,346,648 (+)Marker Load Pipeline
mRatBN7.295,109,826 - 5,109,995 (+)MAPPER
Rnor_6.092,880,977 - 2,881,145NCBI
Rnor_5.092,813,697 - 2,813,865UniSTS
RGSC_v3.492,948,882 - 2,949,051RGD
RGSC_v3.492,948,883 - 2,949,051UniSTS
RGSC_v3.192,948,882 - 2,949,051RGD
Celera91,991,507 - 1,991,679UniSTS
SHRSP x BN Map91.33UniSTS
SHRSP x BN Map91.33RGD
FHH x ACI Map90.08RGD
Cytogenetic Map9 RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Protection against experimental autoimmune encephalomyelitis (EAE) compared to the susceptible parental DA strain, regulation of proinflammatory T cell activation and regulatory T cells. 1302502
strain_reproduction Good breeding performance. 1302502