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Strain Registration

Strain: DA.PVG.1AV1-(D10Got406-D10Rat93)/Kini

Symbol: DA.PVG.1AV1-(D10Got406-D10Rat93)/Kini
Strain: DA.PVG.1AV1-(D10Got406-D10Rat93)
Substrain: Kini
RGD ID: 8552337
Citation ID: RRID:RGD_8552337
Ontology ID: RS:0003746
Also Known As: DA.PVG.1AV1-(D10Got406-D10Rat93)/Kini; DA.PVG.1AV1-Eae18b; NBRP Rat No: 0698
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
Description: Inbred Dark Agouti (DA) rats were originally obtained from Hannover, Germany and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Animals for congenic breeding were selected from the 10th generation of an advanced intercross line (AIL) originating from the EAE-susceptible DA and EAE-resistant PVG.1AV1 rat strains. Selected males containing a PVG.1AV1 fragment in the Eae18b region (from OT24.18 to D10Rat93 marker, at 68.36 Mb and 81.9 Mb, respectively) were backcrossed with DA females for 8 generations, and offspring was genotyped using microsatellite markers in each generation. In the 8th generation, heterozygous males and females were crossed to obtain the experimental population of homozygous congenic rats and littermate controls.
Coat Color: agouti
Last Known Status: Cryopreserved Sperm
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21065,139,038 - 78,210,622RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01067,495,867 - 80,946,110RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01067,154,600 - 80,788,180RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41068,361,384 - 81,887,390RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. Jagodic M, etal., J Immunol 2004 Jul 15;173(2):1366-73.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D10Got406)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21065,139,038 - 65,139,251 (+)MAPPER
Rnor_6.01067,495,867 - 67,496,079NCBI
Rnor_5.01067,154,600 - 67,154,812UniSTS
RGSC_v3.41068,361,384 - 68,361,596UniSTS
Celera1064,101,027 - 64,101,239UniSTS
Cytogenetic Map10q26UniSTS

Flank 2 / 1 (D10Rat93)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21078,210,399 - 78,210,622 (+)MAPPER
Rnor_6.01080,945,888 - 80,946,110NCBI
Rnor_5.01080,787,958 - 80,788,180UniSTS
RGSC_v3.41081,887,167 - 81,887,390RGD
RGSC_v3.41081,887,168 - 81,887,390UniSTS
RGSC_v3.11081,901,538 - 81,901,760RGD
Celera1077,009,632 - 77,009,854UniSTS
RH 3.4 Map10631.5UniSTS
RH 3.4 Map10631.5RGD
RH 2.0 Map10866.0RGD
SHRSP x BN Map1057.43RGD
FHH x ACI Map1062.5499RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Protection against experimental autoimmune encephalomyelitis (EAE) compared to the susceptible parental DA strain and displays higher CCL11 expression. 1302502
strain_reproduction Good breeding performance. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-21 DA.PVG.1AV1-(D10Got406-D10Rat93)/Kini    DA.PVG.1AV1-(D10Got406-D10Rat93)/Kini    Name updated 68913 APPROVED
2014-04-21 DA.PVG.1AV1-(D10Got406-D10Rat93)/Kini    DA.PVG.1AV1-(D10Got406-D10Rat93)/Kini    Name updated 68913 APPROVED