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Strain: Hsd:WI

Symbol: Hsd:WI
Strain: WIST
Substrain: Hsd
Full Name: Wistar
RGD ID: 737960
Citation ID: RRID:RGD_737960
Ontology ID: RS:0001014
Also Known As: WIST/Hsd; Wistar outbred rat
Type: outbred
Available Source: Envigo
Description: These are descendants of rats from the Wistar Institute, Philadelphia, Pennsylvania that are now available from Harlan.
Coat Color: Albino
Last Known Status: Unknown





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
systolic blood pressure
body weight
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
serum creatinine level
right kidney wet weight
left kidney wet weight
both kidneys wet weight
spleen weight to body weight ratio
liver wet weight
spleen wet weight
timed urine volume
both kidneys wet weight to body weight ratio
serum triglyceride level
serum total cholesterol level
serum total bilirubin level
serum calcium level
heart left ventricle weight to body weight ratio
plasma creatinine level
serum albumin level
plasma urea nitrogen level
serum urea nitrogen level
liver weight to body weight ratio
serum total protein level
serum lactate dehydrogenase activity level
urine albumin excretion rate
creatinine clearance
right kidney wet weight to body weight ratio
left kidney wet weight to body weight ratio
plasma uric acid level
neonatal body weight
fetal body weight
change in body weight to body weight ratio
kidney catalase activity to total protein level ratio
kidney glutathione peroxidase activity to total protein level ratio
kidney superoxide dismutase activity to total protein level ratio
kidney paraoxonase1 activity to total protein level ratio
kidney glutathione peroxidase activity to glutathione reductase activity ratio
kidney superoxide dismutase to catalase activity ratio
kidney superoxide dismutase to glutathione peroxidase ratio
kidney superoxide dismutase to paraoxonase1 activity ratio
kidney glutathione level
kidney platinum level
kidney lipid peroxide level
serum oxidized glutathione level
serum glutathione peroxidase activity level
serum superoxide dismutase activity level
serum malondialdehyde level
liver malondialdehyde level to liver weight ratio
kidney glomerular density

References

References - curated
# Reference Title Reference Citation
1. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
2. Effect of Lycopene Against Cisplatin-Induced Acute Renal Injury in Rats: Organic Anion and Cation Transporters Evaluation. Erman F, etal., Biol Trace Elem Res. 2014 Feb 16.
3. Single Nucleotide Polymorphisms associated with rat expressed sequences. Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
4. Benfotiamine enhances antioxidant defenses and protects against cisplatin-induced DNA damage in nephrotoxic rats. Harisa GI J Biochem Mol Toxicol. 2013 Aug;27(8):398-405. doi: 10.1002/jbt.21501. Epub 2013 May 28.
5. Protective effect of lactoferrin on Cisplatin-induced nephrotoxicity in rats. Kimoto Y, etal., J Vet Med Sci. 2013 Feb;75(2):159-64. Epub 2012 Oct 10.
6. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
7. 1,2-Diazole prevents cisplatin-induced nephrotoxicity in experimental rats. Prabhu VV, etal., Pharmacol Rep. 2013;65(4):980-90.
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines
9. Hepatic and renal functions in growing male rats after bisphenol A and octylphenol exposure. Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Recovery of cortonary flow rate was more than 60% of its ischemic value which is similar to SS/JrHsdMcwi and LEW but less than DA/OlaHsd and BN/NHsdMcwi. 1342469
strain_phys_biochem This strain was used for genotyping candidate single nucleotide polymorphisms; SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group 737879

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-14 Hsd:WI  Wistar  Hsd:WIST  Wistar  Name/symbol updated 68913 APPROVED
2011-10-13 Hsd:WIST  Wistar  RccHsd:WIST  Wistar Han  Name/symbol updated 68913 APPROVED
2011-10-12 RccHsd:WIST  Wistar Han  WIST/Hsd    Name/symbol updated 68913 APPROVED