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Strain: WOKW/K

Symbol: WOKW/K
Strain: WOKW
Substrain: K
RGD ID: 737957
RRID: RGD_737957
Ontology ID: RS:0001087
Also known as: MDC-02-92; NBRP Rat No: 0264
Type: inbred
Source: Zentralinstitut fur Diabetes, Division of Laboratory Animal Science, Karlsburg, Germany; National BioResource Project for the Rat in Japan
Origin: Substrain of WOKW (originally designated WOK.W1), from outbred Wistar BB rats by brother x sister mating, selected for homozygosity for RT1U, a haplotype which predisposes to type I diabetes, to Karlsburg after 1991
Coat Color: White
Last Known Status: Unknown
Research Usage Diabetes Obesity; Metabolism



Strain QTL Data
Symbol Name Trait
Bw83 Body weight QTL 83 body mass   (VT:0001259)    
Bw84 Body weight QTL 84 body mass   (VT:0001259)    
Gluco39 Glucose level QTL 39 blood glucose amount   (VT:0000188)    
Gluco40 Glucose level QTL 40 blood glucose amount   (VT:0000188)    
Insul11 Insulin level QTL 11 blood insulin amount   (VT:0001560)    
Scl60 Serum cholesterol level QTL 60 blood cholesterol amount   (VT:0000180)    
Scl61 Serum cholesterol level QTL 61 blood HDL cholesterol amount   (VT:0000184)    
Slep5 Serum leptin concentration QTL 5 blood leptin amount   (VT:0005667)    
Slep6 Serum leptin concentration QTL 6 blood leptin amount   (VT:0005667)    
Stl22 Serum triglyceride level QTL 22 blood triglyceride amount   (VT:0002644)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease These animals develop polygenetically inherited and complete metabolic syndrome with obesity, hyperinsulinemia and insulin resistance, hyperleptinemia, dyslipidemia, hypertension, impaired glucose tolerance (iGT) and proteinuria. 1302502
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-15 WOKW/K    WOKW/K    Name updated 68913 APPROVED
2012-05-15 WOKW/K    WOKW/K    Name updated 68913 APPROVED