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Strain: WOKW/K

Symbol: WOKW/K
Strain: WOKW
Substrain: K
RGD ID: 737957
Citation ID: RRID:RGD_737957
Ontology ID: RS:0001087
Previously known as: MDC-02-92; NBRP Rat No: 0264
Type: inbred
Source: Zentralinstitut fur Diabetes, Division of Laboratory Animal Science, Karlsburg, Germany; National BioResource Project for the Rat in Japan
Origin: Substrain of WOKW (originally designated WOK.W1), from outbred Wistar BB rats by brother x sister mating, selected for homozygosity for RT1U, a haplotype which predisposes to type I diabetes, to Karlsburg after 1991
Coat Color: White
Last Known Status: Unknown
Research Usage Diabetes Obesity; Metabolism


References - curated
# Reference Title Reference Citation
1. Genes on rat chromosomes 3, 5, 10, and 16 are linked with facets of metabolic syndrome. Baguhl R, etal., Obesity (Silver Spring). 2009 Jun;17(6):1215-9. Epub 2009 Feb 19.
2. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
3. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
4. Involvement of cocaine-amphetamine regulated transcript in the differential feeding responses to nociceptin/orphanin FQ in dark agouti and Wistar Ottawa Karlsburg W rats. Filippetti R, etal., Peptides. 2007 Oct;28(10):1966-73. Epub 2007 Aug 10.
5. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
6. Genetic dissection of the syndrome X in the rat. Kovacs P, etal., Biochem Biophys Res Commun 2000 Mar 24;269(3):660-5.
7. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
8. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines
10. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
11. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
12. Metabolic features in disease-resistant as well as in spontaneously hypertensive rats and newly established obese Wistar Ottawa Karlsburg inbred rats. van den Brandt J, etal., Int J Obes Relat Metab Disord. 2000 Dec;24(12):1618-22.
13. Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats. van den Brandt J, etal., Int J Obes Relat Metab Disord. 2002 Apr;26(4):573-6.


Strain QTL Data
Symbol Name Trait
Bw83 Body weight QTL 83 body mass   (VT:0001259)    
Bw84 Body weight QTL 84 body mass   (VT:0001259)    
Gluco39 Glucose level QTL 39 blood glucose amount   (VT:0000188)    
Gluco40 Glucose level QTL 40 blood glucose amount   (VT:0000188)    
Insul11 Insulin level QTL 11 blood insulin amount   (VT:0001560)    
Scl60 Serum cholesterol level QTL 60 blood cholesterol amount   (VT:0000180)    
Scl61 Serum cholesterol level QTL 61 blood HDL cholesterol amount   (VT:0000184)    
Slep5 Serum leptin concentration QTL 5 blood leptin amount   (VT:0005667)    
Slep6 Serum leptin concentration QTL 6 blood leptin amount   (VT:0005667)    
Stl22 Serum triglyceride level QTL 22 blood triglyceride amount   (VT:0002644)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease These animals develop polygenetically inherited and complete metabolic syndrome with obesity, hyperinsulinemia and insulin resistance, hyperleptinemia, dyslipidemia, hypertension, impaired glucose tolerance (iGT) and proteinuria. 1302502
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-15 WOKW/K    WOKW/K    Name updated 68913 APPROVED
2012-05-15 WOKW/K    WOKW/K    Name updated 68913 APPROVED