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Strain Registration

Strain: DA/Ztm

Symbol: DA/Ztm
Strain: DA
Substrain: Ztm
RGD ID: 737950
Citation ID: RRID:RGD_737950
Ontology ID: RS:0000242
Type: inbred
Source: Zentralinstitut fur Versuchstierzucht, Hannover, Germany
Origin: Substrain of DA/OlaHsd, to Hannover after 1965
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains. Backdahl L, etal., Arthritis Rheum 2003 Feb;48(2):551-9.
2. Biochemical markers in inbred strains of the rat (Rattus norvegicus). Bender K, etal., Immunogenetics 1984;19(3):257-66.
3. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
4. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. Bergsteinsdottir K, etal., J Immunol 2000 Feb 1;164(3):1564-8
5. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
6. MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy. de Graaf KL, etal., J Neuroimmunol. 2004 Oct;155(1-2):73-84.
7. Single Nucleotide Polymorphisms associated with rat expressed sequences. Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
8. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
9. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
10. An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. Jagodic M, etal., J Immunol 2004 Jul 15;173(2):1366-73.
11. Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS. Lidman O, etal., J Neurosci 2003 Oct 29;23(30):9817-23.
12. Complex genetic control in a rat model for rheumatoid arthritis. Nordquist N, etal., J Autoimmun 2000 Dec;15(4):425-32.
13. Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice. Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.
14. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
15. RGD Strain RSO annotation pipeline RGD Automated Pipelines
16. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
17. Class II major histocompatibility complex-associated response to type XI collagen regulates the development of chronic arthritis in rats. Tuncel J, etal., Arthritis Rheum. 2012 Aug;64(8):2537-47. doi: 10.1002/art.34461.

Region

Strain QTL Data
Symbol Name Trait
Neudeg1 Neurodegradation QTL 1 nervous system integrity trait   (VT:0010566)    
Neudeg2 Neurodegradation QTL 2 nervous system integrity trait   (VT:0010566)    
Neuinf1 Neuroinflammation QTL 1 nervous system integrity trait   (VT:0010566)    
Neuinf2 Neuroinflammation QTL 2 nervous system integrity trait   (VT:0010566)    
Neuinf3 Neuroinflammation QTL 3 nervous system integrity trait   (VT:0010566)    
Pia7 Pristane induced arthritis QTL 7 joint integrity trait   (VT:0010548)    
Pia8 Pristane induced arthritis QTL 8 joint integrity trait   (VT:0010548)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. This strain was used for genotyping candidate single nucleotide polymorphisms (reference Guryev et al., Single Nucleotide Polymorphisms associated with rat expressed sequences., submitted). SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group 737878

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 DA/Ztm    DA/Ztm    Name updated 68913 APPROVED
2014-07-01 DA/Ztm    DA/Ztm    Name updated 68913 APPROVED