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Strain Registration

Strain: LEW.1AV1

Symbol: LEW.1AV1
Strain: LEW.1AV1
RGD ID: 737657
Citation ID: RRID:RRRC_00201
Ontology ID: RS:0000491
Also Known As: LEW.1AV1(DA)
Type: congenic
Available Source: Not Available
Origination: National Veterinary Institute, Uppsala, Sweden
Description: Originally derived by Dr. Hans J. Hedrich at Versuchstierzucht, Hannover, Germany by transgressing the MHC of DA/Han rats (AV1) into LEW/Han rats for 16 backcross generations. RT1av1 haplotype is a variant to the standard a- haplotype with the difference residing in the atypical MHC class I region.
Inbred Generations: F38
Last Known Status: Extinct

Substrains
LEW.1AV1/Kini

Congenic Strains
LEW.1AV1/Kini




Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
LEW.1AV1RatLEW.1AV1  IEA 7241799 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
LEW.1AV1Ratjoint integrity trait  EXP 61087 RGD 
LEW.1AV1Ratnervous system integrity trait  EXP 629629 RGD 
LEW.1AV1Ratnervous system integrity trait  EXP 2306736 RGD 

References

References - curated
# Reference Title Reference Citation
1. New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Becanovic K, etal., J Immunol 2003 Jan 15;170(2):1062-9.
2. MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy. de Graaf KL, etal., J Neuroimmunol. 2004 Oct;155(1-2):73-84.
3. Rats made congenic for Oia3 on chromosome 10 become susceptible to squalene-induced arthritis. Holm BC, etal., Hum Mol Genet 2001 Mar 15;10(6):565-72.
4. Susceptibility to oil-induced arthritis is linked to Oia2 on chromosome 4 in a DA(DA x PVG.1AV1) backcross. Jansson AM, etal., Transplant Proc 1999 May;31(3):1597-9.
5. Susceptibility of DA rats to arthritis induced with adjuvant oil or rat collagen is determined by genes both within and outside the major histocompatibility complex. Lorentzen JC and Klareskog L, Scand J Immunol 1996 Dec;44(6):592-8.
6. Identification of arthritogenic adjuvants of self and foreign origin. Lorentzen JC Scand J Immunol 1999 Jan;49(1):45-50.
7. Association of arthritis with a gene complex encoding C-type lectin-like receptors. Lorentzen JC, etal., Arthritis Rheum. 2007 Aug;56(8):2620-32.
8. Identification of rat susceptibility loci for adjuvant-oil-induced arthritis. Lorentzen JC, etal., Proc Natl Acad Sci U S A 1998 May 26;95(11):6383-7
9. LEW.1AV1 data personal communication with Dr. Hans J. Hedrich
10. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
11. RGD Strain RSO annotation pipeline RGD Automated Pipelines
12. High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes. Ribbhammar U, etal., Hum Mol Genet 2003 Sep 1;12(17):2087-96.

Region

Strain QTL Data
Symbol Name Trait
Eae16 Experimental allergic encephalomyelitis QTL 16 nervous system integrity trait   (VT:0010566)    
Eae17 Experimental allergic encephalomyelitis QTL 17 nervous system integrity trait   (VT:0010566)    
Ean1 Experimental allergic neuritis QTL 1 nervous system integrity trait   (VT:0010566)    
Oia2 Oil induced arthritis QTL 2 joint integrity trait   (VT:0010548)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems No macroscopic symptoms were observed in rats injected with IFA emulsified with water but when arthritogenic adjuvants like pristane, mycobacteria, MDP, avridine were added arthritis incidence and severity was increased. Beta glucan solution was able to induce arthritis when injected without IFA. 737660
strain_drgs_chems Resistant to arthritis induced by injection of adjuvant oil squalene. 62404
strain_life_disease None of the LEW.1AV1 rats which were injected with IFA (incomplete Freund's adjuvant) developed arthritis whereas only 17% of (DA x LEW.1AV1)F1 , 46% of (DA x LEW.1AV1)F2 and 75% of DA x F1 developed arthritis. 61087
strain_life_disease These are susceptible to collagen-induced arthritis whereas common LEW rats are not. They develop less severe arthritis 30 days after immunization with IFA, hence the arthritis score late in disease is higher than the DA rats. 737659
strain_other The genome of PVG.1AV1 depicts more arthritis resistance than that of LEW.1AV1. 737700

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-03 LEW.1AV1    LEW.1AV1    Name updated 68913 APPROVED
2015-04-03 LEW.1AV1    LEW.1AV1    Name updated 68913 APPROVED
2013-04-15 LEW.1AV1    LEW.1AV1    Name updated 68913 APPROVED
2012-04-18 LEW.1AV1    LEW.1AV1    Name updated 68913 APPROVED
2012-04-18 LEW.1AV1    LEW.1AV1    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00201 RGD