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Strain Registration

Strain: BN.SHR-(Il6-Cd36)/Cub

Symbol: BN.SHR-(Il6-Cd36)/Cub
Strain: BN.SHR-(Il6-Cd36)
Substrain: Cub
RGD ID: 728142
Citation ID: RRID:RGD_728142
Ontology ID: RS:0000129
Also Known As: BN.SHR4; BN.SHR-(Il6-Cd36)/Cub; BN-SHR4
Type: congenic
Available Source: Not Available
Origination: Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Description: This congenic strain has a segment of chr 4 which was of SHR origin. The length of the differential segment is 10 cM and has a defective cd36 allele of SHR.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,214,602 - 17,410,084RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.043,043,231 - 14,191,498RGD_MAPPER_PIPELINERnor6.0
Rnor_5.043,095,536 - 14,166,434RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.44456,799 - 13,554,416RGD_MAPPER_PIPELINERGSC3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Pharmacogenetic interaction between dexamethasone and Cd36-deficient segment of spontaneously hypertensive rat chromosome 4 affects triacylglycerol and cholesterol distribution into lipoprotein fractions. Krupkova M, etal., Lipids Health Dis. 2010 Apr 16;9:38.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Metabolic characterization of insulin resistance syndrome feature loci in three brown Norway-derived congenic strains. Seda O, etal., Folia Biol (Praha) 2002;48(3):81-8.
4. Rosiglitazone fails to improve hypertriglyceridemia and glucose tolerance in CD36-deficient BN.SHR4 congenic rat strain. Seda O, etal., Physiol Genomics 2003 Jan 15;12(2):73-8.

Region

Position Markers

Flank 1 / 1 (Il6)
Rat AssemblyChrPosition (strand)Source
GRCr845,889,999 - 5,894,575 (-)NCBI
mRatBN7.245,214,602 - 5,219,178 (-)NCBI
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)Ensembl
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBI
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBI
Rnor_6.043,043,231 - 3,047,807 (+)NCBI
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)Ensembl
Rnor_5.043,095,536 - 3,100,112 (+)NCBI
RGSC_v3.44456,799 - 461,376 (-)NCBI
RGSC_v3.14456,798 - 461,376 (-)NCBI
Celera45,093,593 - 5,098,169 (+)NCBI
Cytogenetic Map4q11NCBI

Flank 2 / 1 (Cd36)
Rat AssemblyChrPosition (strand)Source
GRCr8418,209,088 - 18,302,142 (+)NCBI
mRatBN7.2417,317,343 - 17,410,084 (+)NCBI
mRatBN7.2 Ensembl417,354,466 - 17,513,903 (+)Ensembl
UTH_Rnor_SHR_Utx422,477,636 - 22,533,306 (+)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.0418,290,445 - 18,348,857 (+)NCBI
UTH_Rnor_WKY_Bbb_1.0416,675,588 - 16,731,247 (+)NCBI
Rnor_6.0414,150,309 - 14,191,498 (+)NCBI
Rnor_6.0 Ensembl414,001,761 - 14,249,749 (+)Ensembl
Rnor_5.0414,125,297 - 14,166,434 (+)NCBI
RGSC_v3.4413,534,582 - 13,554,416 (+)NCBI
Celera412,880,238 - 12,941,086 (+)NCBI
Cytogenetic Map4q11NCBI

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Shows a significant increase in triglyceride level when fed a high-sucrose diet for 1 week. 632347
strain_life_disease This region is important for dyslipidemia and insulin resistance. 632347