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Strain Registration

Strain: MWF/FubRkb

Symbol: MWF/FubRkb
Strain: MWF
Substrain: FubRkb
Full Name: Munich Wistar Fromter
RGD ID: 724569
Citation ID: RRID:RGD_724569
Ontology ID: RS:0000596
Also Known As: MWF/Rkb
Type: inbred
Available Source: Not Available
Origination: Freie Universitdt Berlin, Berlin, Germany
Description: The MWF/FubRkb strain was established in generation F45 in 1996 by further inbreeding of rats obtained from the original colony (MWF/Ztm).
Last Known Status: Unknown





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Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
body weight
heart weight
plasma glucose level
serum creatinine level
heart wet weight
heart weight to body weight ratio
kidney weight
single kidney wet weight
both kidneys wet weight
timed urine volume
both kidneys wet weight to body weight ratio
serum triglyceride level
serum total cholesterol level
tibia length
heart left ventricle weight to body weight ratio
kidney glomerulus count
serum urea nitrogen level
single kidney wet weight to body weight ratio
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
urine total protein excretion rate
urine albumin excretion rate
creatinine clearance
heart left ventricle weight
count of superficial glomeruli directly contacting the kidney surface
count of superficial glomeruli not directly contacting the kidney surface
creatinine clearance to body weight ratio
kidney fibrotic lesion area to total kidney area ratio
neonatal body weight
fetal body weight
number of podocytes per kidney glomerulus
kidney wet weight to body weight ratio
kidney glomerular density
pulse wave velocity
mesenteric artery wall thickness
mesenteric artery media thickness
mesenteric artery adventitial thickness
norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL
negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value
heart left ventricle interstitial fibrotic lesion area to total heart left ventricule area ratio
heart left ventricle perivascular fibrotic lesion area to total heart left ventricule area ratio
kidney interstitial fibrotic lesion area to total kidney area ratio
glomerular volume per podocyte
number of glomeruli per kidney
body length, crown to rump
number of ureteric bud tips per kidney
number of glomeruli per kidney to number of ureteric bud tips per kidney ratio

References

References - curated
# Reference Title Reference Citation
1. Finerenone Reduces Intrinsic Arterial Stiffness in Munich Wistar Frömter Rats, a Genetic Model of Chronic Kidney Disease. Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.
2. Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich-Wistar-Fromter rats. Ijpelaar DH, etal., Am J Physiol Renal Physiol. 2008 Apr;294(4):F758-67. Epub 2008 Jan 16.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Impact of nephron number dosing on cardiorenal damage and effects of ACE inhibition. Rothermund L, etal., Am J Hypertens. 2011 Apr;24(4):474-81. doi: 10.1038/ajh.2010.206. Epub 2010 Sep 23.
5. Genetic low nephron number hypertension is associated with dysregulation of the hepatic and renal insulin-like growth factor system during nephrogenesis. Rothermund L, etal., J Hypertens. 2006 Sep;24(9):1857-64. doi: 10.1097/01.hjh.0000242411.50536.b9.
6. MWF rats with spontaneous albuminuria inherit a reduced efficiency of nephron induction during early nephrogenesis in comparison to SHR rats. Schulte L, etal., J Hypertens. 2012 Oct;30(10):2031-8. doi: 10.1097/HJH.0b013e328356a60a.
7. Protective effect of female gender on the development of albuminuria in a polygenetic rat model is further enhanced by replacement of a major autosomal QTL. Schulz A, etal., Clin Sci (Lond). 2007 Oct 22;.
8. Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. Schulz A, etal., Elife. 2019 Mar 22;8. pii: 42068. doi: 10.7554/eLife.42068.
9. Genetic dissection of increased urinary albumin excretion in the munich wistar fromter rat. Schulz A, etal., J Am Soc Nephrol 2002 Nov;13(11):2706-14.
10. A major gene locus links early onset albuminuria with renal interstitial fibrosis in the MWF rat with polygenetic albuminuria. Schulz A, etal., J Am Soc Nephrol 2003 Dec;14(12):3081-9.
11. Development of overt proteinuria in the Munich Wistar Fromter rat is suppressed by replacement of chromosome 6 in a consomic rat strain. Schulz A, etal., J Am Soc Nephrol. 2007 Jan;18(1):113-21. Epub 2006 Dec 13.
12. Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Fromter rat. Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22.
13. A genetic locus on MWF rat chromosome 6 affects kidney damage in response to L-NAME treatment in spontaneously hypertensive rats. Schulz A, etal., Physiol Genomics. 2010 Apr 13.
14. Dissecting the genetic predisposition to albuminuria and endothelial dysfunction in a genetic rat model. Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.

Region

Strain QTL Data
Symbol Name Trait
Bp145 Blood pressure QTL 145 arterial blood pressure trait   (VT:2000000)    
Bp146 Blood pressure QTL 146 arterial blood pressure trait   (VT:2000000)    
Bp147 Blood pressure QTL 147 arterial blood pressure trait   (VT:2000000)    
Glom1 Glomerulus QTL 1 kidney glomerulus morphology trait   (VT:0005325)    
Glom2 Glomerulus QTL 2 kidney glomerulus morphology trait   (VT:0005325)    
Glom3 Glomerulus QTL 3 kidney glomerulus morphology trait   (VT:0005325)    
Uae1 Urinary albumin excretion QTL 1 urine albumin amount   (VT:0002871)    
Uae2 Urinary albumin excretion QTL 2 urine albumin amount   (VT:0002871)    
Uae3 Urinary albumin excretion QTL 3 urine albumin amount   (VT:0002871)    
Uae4 Urinary albumin excretion QTL 4 urine albumin amount   (VT:0002871)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy The strain exhibits an increased number of surface glomeruli. 634618
strain_characteristics Females have lower blood pressure, mild albuminuria and no signs of glomerulosclerosis 1642911
strain_life_disease Develops mild hypertension and an increased urinary albumin excretion as compared to a normal Lewis rat. 634618
strain_life_disease The development of protenuric renal disease is accelerated and increased in the males. 634618
strain_life_disease The development of protenuric renal disease is accelerated and increased in the males. 730279
strain_phys_biochem Have a lower number of nephrons as compared to other strains. 634618