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Strain Registration

Strain: (SDxF344)F1-Rbm20m1Mlgw

Symbol: (SDxF344)F1-Rbm20m1Mlgw
Strain: (SDxF344)F1-Rbm20m1
Substrain: Mlgw
RGD ID: 7241594
Citation ID: RRID:RGD_7241594
Ontology ID: RS:0003417
Alleles: Rbm20m1Mlgw
Also Known As: (SDxF344)F1-Rbm20m1Mlgw; (SDxF344)F1-Rbm20^[m1Mlgw]
Type: mutant
Available Source: Not Available
Origination: University of Wisconsin, Madison
Description: This mutation, a deletion in chromosome 1 between bp 260,070,892 and 260,166,363, was originally found in the offspring of Hsd:SD x Hsd:SD. The phenotype was an altered titin isoform expression in the offspring. The parent carrier was identified by crossing both the male and the female Hsd:SD with F344/NHsd. This mutation is maintained on Hsd:SD X F344/NHsd.
Coat Color: White
Last Known Status: Cryopreserved Sperm (as of 2017-01-25)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81262,671,311 - 262,912,551RGD_MAPPER_PIPELINE
mRatBN7.21252,683,760 - 252,907,465RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01274,391,932 - 274,589,816RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01281,783,646 - 282,003,053RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41259,905,545 - 260,144,190RGD_MAPPER_PIPELINERGSC3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Developmental changes in rat cardiac titin/connectin: transitions in normal animals and in mutants with a delayed pattern of isoform transition. Greaser ML, etal., J Muscle Res Cell Motil. 2005;26(6-8):325-32.
2. RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Guo W, etal., Nat Med. 2012 May;18(5):766-73. doi: 10.1038/nm.2693.
3. Pathophysiological defects and transcriptional profiling in the RBM20-/- rat model. Guo W, etal., PLoS One. 2013 Dec 19;8(12):e84281. doi: 10.1371/journal.pone.0084281. eCollection 2013.
4. Data registered by Dr. Greaser Personal communication between Dr. Greaser and the RGD curators.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-03 (SDxF344)F1-Rbm20m1Mlgw    (SDxF344)F1-Rbm20m1Mlgw    Symbol updated 68687 APPROVED
2014-04-03 (SDxF344)F1-Rbm20m1Mlgw    (SDxF344)F1-Rbm20m1Mlgw    Symbol updated 68687 APPROVED
2014-04-03 (SDxF344)F1-Rbm20m1Mlgw    (SDxF344)F1-Rbm20m1Mlgw    Name updated 68913 APPROVED
2014-04-03 (SDxF344)F1-Rbm20m1Mlgw    (SDxF344)F1-Rbm20m1Mlgw    Name updated 68913 APPROVED
2013-08-15 (SDxF344)F1-Rbm20m1Mlgw    (SDxF344)F1-Rbm20m1Mlgw    Name updated 68913 APPROVED
2013-08-15 (SDxF344)F1-Rbm20m1Mlgw    (SDxF344)F1-Rbm20m1Mlgw    Name updated 68913 APPROVED