Strain Report - Rat Genome Database

Name: LE- Lrrk2 em1Sage-/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Strain Registration

General

Strain: LE-Lrrk2^em1Sage-/-

Symbol:

LE-Lrrk2^em1Sage-/-

Strain:

LE-Lrrk2^em1-/-

Substrain:

Sage

RGD ID:

7241056

Citation ID:

RRID:RGD_7241056

Ontology ID:

RS:0003393

Alleles:

Lrrk2^em1Sage

Also Known As:

LE-Lrrk2em1Sage-/-; LE-Lrrk2em1Sage-/Lrrk2em1Sage-; TGRL4620 ; LE-Lrrk2^[em1Sage-/-]

Type:

mutant

Available Source:

Sigma Advanced Genetic Engineering Labs

Origination:

Sigma Advanced Genetic Engineering Labs

Description:

ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offspring which were intercrossed and offsprings maintained as homozygous

Genetic Status:

Homozygous

Last Known Status:

Live Animals (as of 2018-08-24)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	122,826,696 - 122,987,711	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	7	132,857,311 - 133,018,549	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	7	132,531,591 - 132,694,226	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	7	130,105,902 - 130,267,747	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

synucleinopathy (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal circulating aspartate transaminase level (IMP)

decreased circulating alanine transaminase level (IMP)

decreased circulating bilirubin level (IMP)

decreased circulating chloride level (IMP)

decreased circulating potassium level (IMP)

decreased circulating prolactin level (IMP)

decreased circulating triglyceride level (IMP)

decreased eosinophil cell number (IMP)

decreased erythrocyte cell number (IMP)

decreased hemoglobin content (IMP)

decreased lymphocyte cell number (IMP)

decreased surfactant secretion (IMP)

enlarged alveolar lamellar bodies (IMP)

hypersecretion of adrenocorticotropin (IMP)

increased alveolar lamellar body number (IMP)

increased body weight (IMP)

increased brain size (IMP)

increased brain weight (IMP)

increased circulating cholesterol level (IMP)

increased circulating creatinine level (IMP)

increased circulating luteinizing hormone level (IMP)

increased circulating serum albumin level (IMP)

increased susceptibility to weight gain (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

body weight

heart weight

red blood cell count

blood hemoglobin level

white blood cell count

platelet count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

red blood cell distribution width-coefficient of variation

blood urea nitrogen level

plasma total protein level

plasma albumin level

serum creatinine level

plasma phosphate level

plasma chloride level

plasma sodium level

plasma potassium level

plasma calcium level

liver weight

lung weight

liver weight as percentage of body weight

urine specific gravity

timed urine volume

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

blood insulin level

serum total cholesterol level

blood basophil count to total leukocyte count ratio

blood eosinophil count to total leukocyte count ratio

blood lymphocyte count to total leukocyte count ratio

blood monocyte count to total leukocyte count ratio

urine chloride level

serum sodium level

blood testosterone level

blood progesterone level

blood cortisol level

plasma creatinine level

serum phosphate level

plasma triglyceride level

blood adrenocorticotropic hormone level (ACTH)

blood alanine aminotransferase activity level

blood alkaline phosphatase activity level

blood angiotensin I converting enzyme activity level

blood aspartate aminotransferase activity level

plasma total cholesterol level

thymus weight

thymus weight to body weight ratio

single kidney wet weight to body weight ratio

creatinine clearance

blood leptin level

both testes wet weight to body weight ratio

blood insulin-like growth factor 1 level

blood prolactin level

plasma gamma-glutamyltransferase activity level

plasma total bilirubin level

blood segmented neutrophil count

blood segmented neutrophil count to total leukocyte count ratio

lung wet weight to body weight ratio

serum cystatin C level

urine sodium level to urine creatinine level ratio

urine potassium level to urine creatinine level ratio

gastrointestinal tract weight

reticulocyte count to total red blood cell count ratio

urine chloride level to urine creatinine level ratio

gastrointestinal tract weight to body weight ratio

blood galanin level

blood lutenizing hormone level

urine lipocalin 2 level

urine osteopontin level

urine KIM-1/TIM-1/HAVCR level

serum beta-2 microglobulin

serum calbindin level

serum clusterin level

serum glutathione S-transferase-alpha level

serum glutathione S-transferase-u level

serum tissue inhibitor of metalloproteinase 1 level

serum vascular endothelial growth factor A level

serum lipocalin 2 level

serum osteopontin level

serum KIM-1/TIM-1/HAVCR1

serum sorbital dehydrogenase activity

plasma plasminogen activator inhibitor 1 level

plasma Complement C3a des Arg level

References

References - curated

#	Reference Title	Reference Citation
1.	Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs.	Baptista MA, etal., PLoS One. 2013 Nov 14;8(11):e80705. doi: 10.1371/journal.pone.0080705. eCollection 2013.
2.	Abrogation of a-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.	Daher JP, etal., Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94. doi: 10.1073/pnas.1403215111. Epub 2014 Jun 9.
3.	Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.	Miklavc P, etal., PLoS One. 2014 Jan 21;9(1):e84926. doi: 10.1371/journal.pone.0084926. eCollection 2014.
4.	Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis.	Ness D, etal., PLoS One. 2013 Jun 14;8(6):e66164. doi: 10.1371/journal.pone.0066164. Print 2013.
5.	Data registered by Sigma Advanced Genetic Engineering Labs	Personal communication with SAGE Labs and RGD curators
6.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2016-04-27	LE-Lrrk2^em1Sage-/-	LE-Lrrk2^em1Sage-/-	Name updated	68913	APPROVED
2016-04-27	LE-Lrrk2^em1Sage-/-	LE-Lrrk2^em1Sage-/-	Name updated	68913	APPROVED
2014-04-03	LE-Lrrk2^em1Sage-/-	LE-Lrrk2^em1Sage-/-	Name updated	68913	APPROVED
2014-04-03	LE-Lrrk2^em1Sage-/-	LE-Lrrk2^em1Sage-/-	Name updated	68913	APPROVED
2014-04-03	LE-Lrrk2^em1Sage-/-	LE-Lrrk2^em1Sage-/-	Symbol updated	68687	APPROVED
2014-04-03	LE-Lrrk2^em1Sage-/-	LE-Lrrk2^em1Sage-/-	Symbol updated	68687	APPROVED
2013-02-26	LE-Lrrk2^em1Sage-/-	LE-Lrrk2^em1Sage-/-	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: LE-Lrrk2em1Sage-/-

Mammalian Phenotype

Related Phenotype Data for Term "LE-Lrrk2em1Sage-/-" (RS:0003393)

Strain: LE-Lrrk2^em1Sage-/-