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Strain Registration

Strain: LE-Prknem1Sage-/-

Symbol: LE-Prknem1Sage-/-
Strain: LE-Prknem1-/-
Substrain: Sage
RGD ID: 7241052
Citation ID: RRID:RGD_7241052
Ontology ID: RS:0003390
Alleles: Prknem1Sage
Also Known As: LE-Park2em1Sage-/-; LE-Park2em1Sage-/Park2em1Sage-; Park2 (Parkin) Knockout Rat; LEH- Park2 tm1sage; TGRL4760 ; LE-Prkn em1Sage-/-; LE-Prkn^[em1Sage-/-]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous. The resulting mutation is a 5-bp frameshift deletion in exon 4 (TCAGT).
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,688,651 - 49,882,520RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0148,880,015 - 50,069,998RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0149,684,308 - 50,875,397RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4143,151,265 - 44,374,470RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
2. Data registered by Sigma Advanced Genetic Engineering Labs Personal communication with SAGE Labs and RGD curators
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-14 LE-Prknem1Sage-/-    LE-Prkn em1Sage-/-    Symbol updated 68687 APPROVED
2018-03-14 LE-Prknem1Sage-/-    LE-Prkn em1Sage-/-    Symbol updated 68687 APPROVED
2017-09-05 LE-Prkn em1Sage-/-    LE-Park2em1Sage-/-    Symbol updated 68687 APPROVED
2017-09-05 LE-Prkn em1Sage-/-    LE-Park2em1Sage-/-    Symbol updated 68687 APPROVED
2014-04-03 LE-Park2em1Sage-/-    LE-Park2em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Park2em1Sage-/-    LE-Park2em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Park2em1Sage-/-    LE-Park2em1Sage-/-    Symbol updated 68687 APPROVED
2014-04-03 LE-Park2em1Sage-/-    LE-Park2em1Sage-/-    Symbol updated 68687 APPROVED
2013-02-26 LE-Park2em1Sage-/-    LE-Park2em1Sage-/-    Name updated 68913 APPROVED
2013-02-26 LE-Park2em1Sage-/-    LE-Park2em1Sage-/-    Name updated 68913 APPROVED