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Strain: AO

Symbol: AO
Strain: AO
RGD ID: 70429
Citation ID: RRID:RGD_70429
Ontology ID: RS:0000050
Type: inbred
Source: Not Available
Origin: From ARC Compton, probably as "WAG", to Gowans, Oxford 1957. Appears to differ from other WAG sublines in having A at the agouti locus. Resistant to the development of experimental allergic encephalomyelitis upon treatment with a myelin basic protein-specific T cell line derived from an F1 hybrid between resistant AO and susceptible DA strain rats. This resistance was not abrogated by deletion of host's leukocytes using sublethal irradiation and cytotoxi drugs (Mostaricastrojkovic et al, 1992). Susceptible (2/4) to ocular infection with herpes simplex virus. PVG was relatively resistant (Nicholls et al, 1994). Met-enkephalin decreased H2O2 production by macrophages (contrast DA) (Radulovic et al, 1995).
Genetic Markers: A, c, h
Coat Color: Albino
Inbred Generations: F?+48
Last Known Status: Unknown


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References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Rat Strain List M. Festing Rat Strain List
3. Ocular infection with herpes simplex virus in several strains of rat. Nicholls SM, etal., Invest Ophthalmol Vis Sci. 1994 Jul;35(8):3260-7.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines


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