Germ-free strain developed by Gustafsson from stock (Sprague-Dawley?) by hysterectomy derivation in 1948 at F10. To Laboratory Animals Centre, Carshalton 1968 at F26.
Susceptible to experimental allergic encephalitis (Hughes and Stedronska 1973). Relatively resistant to infection by Entamoeba histolytica (Neal and Harris 1975). Good breeding performance, although sensitive to environmental influences. About 1-4% tailless young, which are infertile with major skeletal and genital defects (Lovell and Sparrow 1984). Long gestation period (3/8) (Peters 1986). Absence of a microflora in germfree AGUS rats prolongs the cell cycle time and reduces proliferative activity in the colonic crypts (Alam et al 1994).
Susceptible to experimental allergic encephalitis (Hughes and Stedronska 1973). Relatively resistant to infection by Entamoeba histolytica (Neal and Harris 1975). Good breeding performance, although sensitive to environmental influences. About 1-4% tailless young, which are infertile with major skeletal and genital defects (Lovell and Sparrow 1984). Long gestation period (3/8) (Peters 1986). Absence of a microflora in germfree AGUS rats prolongs the cell cycle time and reduces proliferative activity in the colonic crypts (Alam et al 1994).